Drug Delivery Systems
Mostrando 1-12 de 168 artigos, teses e dissertações.
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1. BINARY MICELLES (E45S8/F127) FOR QUERCETIN AND GRISEOFULVIN SOLUBILISATION
Micelles have aroused interest due to their ability to assist in the transport of poorly soluble drugs. In this study the mixture of copolymers F127/E45S8 in different proportions (F/ES 30/70, 50/50 and 70/30) was performed to improve the bioavailability of griseofulvin and quercetin. The results of cytotoxicity (MTT assay) revealed that the copolymers F127
Quím. Nova. Publicado em: 2020-09
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2. EVALUATION OF SILICA NANOPARTICLE COLLOIDAL STABILITY WITH A FIBER OPTIC QUASI-ELASTIC LIGHT SCATTERING SENSOR
Abstract Colloidal silica is an important biocompatible, inert and non-toxic material for imaging, therapy, and drug delivery biomedical applications. In this context, the evaluation of colloidal suspensions and their stabilities by a Fiber Optic Quasi-Elastic Light Scattering sensor is proposed. Two different silica nanoparticles were prepared and character
Braz. J. Chem. Eng.. Publicado em: 13/01/2020
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3. Access to high-cost medications for psoriatic arthritis in the National Health System in Brazil: the long path up to dispensation
Abstract Background: Pharmaceutical Assistance (PA) is a dynamic and multidisciplinary process that aims to supply health systems, programs or services with quality medicines, enabling access and health care, in an efficient and timely manner. The objective of the study was to evaluate the profile of administrative processes for the treatment of PsA, identi
Adv. rheumatol.. Publicado em: 28/11/2019
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4. Doxycycline release and antibacterial activity from PMMA/PEO electrospun fiber mats
Abstract Objective: To investigate the use of polymethyl methacrylate (PMMA) electrospun fiber mats containing different amounts of polyethylene oxide (PEO) as a doxycycline delivery system and to test antibacterial activity against an oral pathogen. Methodology: PMMA powders or PEO (mol wt 200 Kd) (10,20,30% w/w/) were dissolved in N, N-dimethylformamide
J. Appl. Oral Sci.. Publicado em: 07/10/2019
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5. HYDROXYAPATITE - CARBON NANOTUBE COMPOSITES FOR DRUG DELIVERY APPLICATIONS
Abstract The aim of this study was the synthesis of composites containing hydroxyapatite (Hap) or silicon substituted hydroxyapatite (HapSi), carboxyl functionalized carbon nanotubes (fMWCNT) and gelatin (G) in different ratios. Ibuprofen (IBU) was chosen as a model drug for the formulation of extended-release dosage forms. The obtained composites were chara
Braz. J. Chem. Eng.. Publicado em: 30/09/2019
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6. Development and in vitro/in vivo evaluation of thermo-sensitive in situ gelling systems for ocular allergy
Ocular allergy is one of the most common disorders of the eye surface. Following diagnosis this condition is typically treated with preparations containing antihistamines. However, anatomy of the eye and its natural protective mechanisms create challenges for ocular drug delivery. Rapid elimination of antihistamine substances due to short residency times fol
Braz. J. Pharm. Sci.. Publicado em: 23/09/2019
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7. Desenvolvimento e caracterização de membranas de quitosana / Cissus Verticillata (L.) Nicolson & C.E. Jarvis
RESUMO Os polímeros, devido às suas diversas aplicações e funcionalidades, estão entre os excipientes mais utilizados para a obtenção de formas farmacêuticas, ganhando destaque a quitosana. O objetivo deste trabalho foi desenvolver e avaliar comparativamente membranas de quitosana com diferentes concentrações da espécie vegetal Cissus verticillata
Matéria (Rio J.). Publicado em: 16/09/2019
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8. Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery
The efficacy of conventional ocular formulations is limited by poor corneal retention and permeation, resulting in low ocular bioavailability. Mucoadhesive chitosan (CS)/ tripolyphosphatesodium (TPP) and chitosan (CS)/ tripolyphosphatesodium (TPP)-alginate (ALG) nanoparticles were investigated for the prolonged topical ophthalmic delivery of ofloxacin. A mod
Braz. J. Pharm. Sci.. Publicado em: 15/08/2019
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9. Synthesis of ordered mesoporous silica MCM-41 with controlled morphology for potential application in controlled drug delivery systems
Resumo O MCM-41 é uma das cerâmicas mesoporosas mais estudadas para sistemas de liberação controlada de fármacos. Sua elevada área superficial específica e mesoporosidade permitem alta capacidade de adsorção. Apesar dos inúmeros trabalhos publicados na área biomédica, até o presente momento não há relatos de aplicações comerciais do MCM-41.
Cerâmica. Publicado em: 06/06/2019
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10. Drug use in delivery hospitalization: Pelotas births cohort, 2015
RESUMO OBJETIVO: Identificar o padrão de uso dos medicamentos durante a internação para o parto. MÉTODO: Estudo transversal realizado de junho a outubro de 2015, inserido na coorte de nascimentos de Pelotas de 2015. Todas as mulheres residentes na zona urbana da cidade que foram internadas para o parto fizeram parte da amostra. Foram coletadas informa�
Rev. Saúde Pública. Publicado em: 30/05/2019
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11. Development and evaluation of multiparticulate biphasic system for the treatment of circadian diseases
Multiparticulate systems have biopharmaceutical advantages when compared to the monolithic systems, once they allow different patterns of drug release and can be used in different treatments. The aim of the present work was to develop a biphasic controlled release delivery system, using propranolol hydrochloride (PROP) that can be used for the treatment of c
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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12. Nanoparticulate drug delivery systems for the treatment of neglected tropical protozoan diseases
Abstract Neglected Tropical Diseases (NTDs) comprise of a group of seventeen infectious conditions endemic in many developing countries. Among these diseases are three of protozoan origin, namely leishmaniasis, Chagas disease, and African trypanosomiasis, caused by the parasites Leishmania spp., Trypanosoma cruzi, and Trypanosoma brucei respectively. These d
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/02/2019