Dna Adducts
Mostrando 1-12 de 388 artigos, teses e dissertações.
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1. DNA Damage by Endogenous and Exogenous Aldehydes
The present overview describes the formation of deoxyribonucleic acid (DNA) adducts from endogenous and exogenous aldehydes, such as acetaldehyde, acrolein, crotonaldehyde, malonaldehyde, 4-hydroxy-2-nonenal and 2,4-decadienal. Malonaldehyde reacts with 2’-deoxyguanosine, 2’-deoxyadenosine, and 2’-deoxycytidine, yielding cyclic pyrimidopurinone and acy
J. Braz. Chem. Soc.. Publicado em: 21/10/2019
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2. Carbonyl compounds in wine: factors related to presence and toxic effects
RESUMO: O objetivo deste estudo foi revisar os fatores tecnológicos e toxicológicos relacionados à presença de compostos carbonílicos encontrados em vinhos, incluindo acetaldeído, formaldeído, acroleína, carbamato de etila (CE) e furfural. O acetaldeído e o formaldeído podem ser formados através da oxidação do etanol e do metanol, respectivament
Cienc. Rural. Publicado em: 29/07/2019
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3. A Importância da determinação analítica de intermediários reativos e de seus produtos de reações com biomacromoléculas: uma mini revisão
Metabolic reactive intermediates can react with biomolecules such as DNA and proteins to produce adducts. Recently, research has shown that such adducts can act as precursors of some chronic diseases (cancer, Parkinson's, immunologic system diseases, etc.), and their determination is important because they are biomarkers of undesirable health effects. These
Quím. Nova. Publicado em: 2014-04
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4. Investigação da reação de Morita-Baylis-Hillman em reator de micro-ondas usando aldeídos aromáticos e isatina como eletrófilos: avaliação da atividade citotóxica em linhagem de células de leucemia promielocítica humanas (HL-60). / Investigation of Morita-Baylis-Hillman Reaction on Microwave Reactor using Aromatic Aldehydes and Isatin as Eletrophiles: Evaluation of Cytotoxic Activity in cell line human promyelocytic leukemia (HL-60).
In this work, we describe the investigation of the Morita-Baylis-Hillman reaction in microwave reactor, under closed vessel conditions to prepare 40 adducts, six novel, using 30 aromatic aldehydes and isatin as electrophiles and acrylonitrile (62a) , methyl acrylate (2), hydroxyethyl acrylate (62b), 2,2-dimethyl-1 ,3-dioxalyl acrylate (62c) and 2,3-dihydroxy
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/11/2012
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5. Temozolomide in aggressive pituitary adenomas and carcinomas
Temozolomide is an alkylating agent used in the treatment of gliomas and, more recently, aggressive pituitary adenomas and carcinomas. Temozolomide methylates DNA and, thereby, has antitumor effects. O6-methylguanine-DNA methyltransferase, a DNA repair enzyme, removes the alkylating adducts that are induced by temozolomide, thereby counteracting its effects.
Clinics. Publicado em: 2012
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6. Assessment of cellular responses mediated by temozolomide combined with metoxiamina, an inhibitor of DNA repair, in glioblastoma cell lines. / Avaliação da resposta celular mediada pelo quimioterápico temozolomida associada ao inibidor do reparo do DNA metoxiamina em linhagens de glioblastoma.
Gliomas represent more than 70% of primary brain tumors. Even following an aggressive therapies, the mean survival rate of patients with these tumors is less than one year after diagnosis. Chemotherapy based on alkyklating agents, such as temozolomide (TMZ) has been reported to increase the survival rate. N7-metyl-G and N3-metyl-A adducts comprise more than
Publicado em: 2009
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7. Interações de peroxirredoxinas citossólicas da levedura Saccharomyces cerevisiae com peróxidos. Estudos cinéticos e funcionais / Saccharomyces cerevisiae cytosolic peroxiredoxin interactions with peroxides. Kinetics and functional studies
Peroxiredoxins constitute a family of cysteine-based peroxidases that are able to reduce hydrogen peroxide, organic peroxides and peroxinitrite to water, alcohol and nitrite, respectively, through the use of reducing equivalents provided by thioredoxin, thioredoxin reductase and NADPH. Peroxiredoxins are abundant enzymes (correspond to approximately 0.7% of
Publicado em: 2009
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8. Poliformismos genéticos no câncer de cabeça e pescoço: análise de risco e evolução clínica / Genetic polymorphisms in head and neck cancer: analysis of risk and clinical evolution
The squamous cell carcinoma of the head and neck (HNSCC) is considered one of the most prevalent cancers in developing countries, detected nearly always in well-advanced phases with few effective treatment options, which reduce the survival rate to five years in 50% of the patients. The main risk factors associated with it are tobacco and alcohol intake, fol
Publicado em: 2008
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9. Adducts of 2-desoxiadenosine and 2-desoxicitydine induced of tetrahydrofuran: structural characterization and detection in DNA / Adutos de 2-desoxiadenosina e 2-desoxicitidina induzidos por tetraidrofurano: caracterização estrutural e detecção em DNA
There is a huge concern to identify compounds involved in the development of harmful processes, like cancer. Tetrahydrofuran (THF) is a solvent widely used in industries and recent researches and studies indicated a carcinogenic activity in experimental animals, instigating the investigation of its possible interaction with biomolecules. DNA adducts are used
Publicado em: 2007
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10. Investigação de lesões em DNA induzidas pelo hidrocarboneto policíclico aromático antantreno / Investigation of DNA damage induced by polycyclic aromatic hydrocarbon anthanthrene.
Anthanthrene is a polycyclic aromatic hydrocarbon (PAH) widely spread in the environment and does not have the bay or fjord regions, which in general provide high reactivity to these compounds after oxidation. However, its mutagenic activity to bacteria after metabolic activation is comparable to that of benzopyrene (BP) and, based on the sensitivity of the
Publicado em: 2007
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11. Investigação de lesões em DNA induzidas por produtos de redução do corante C. I. Disperse Blue 291 / Investigation of DNA damage induced by products of the C.I. Disperse Blue 291 reduction 2007
CI Disperse Blue 291 (CI DB 291) é um corante dinitrobromoaminoazobenzeno com atividade mutagênica para S. typhimurium, aumentada na presença de nitrorredutase, o-acetiltransferase e enzimas microssomais (S9). Neste estudo foram isolados e caracterizados quatro produtos da redução de DB 291 com ditionito de sódio (in vitro), sendo denominados 2- fenilb
Publicado em: 2007
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12. Investigação da citotoxicidade e genotoxicidade dos hidrocarbonetos policíclicos aromáticos indeno[1,2,3-cd]pireno, trifenileno e coroneno / Investigation of Cytotoxicity and Genotoxicity of Aromatic Polycyclic Hydrocarbons Indene[1,2,3-cd]pyrene, triphenylene and coronene
Exposição a Hidrocarbonetos policíclicos aromáticos (HPAs) está relacionada com o aumento de risco de câncer. Esses carcinógenos dependem da sua ativação para intermediários eletrofílicos para causar danos em biomoléculas. As vias de ativação melhor estudadas incluem (i) a formação de diol-epóxido nas regiões de baía ou fjord dos HPAs atra
Publicado em: 2007