Disintegrins
Mostrando 1-12 de 15 artigos, teses e dissertações.
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1. Cell migration inhibition activity of a non-RGD disintegrin from Crotalus durissus collilineatus venom
Abstract Background: In recent decades, snake venom disintegrins have received special attention due to their potential use in anticancer therapy. Disintegrins are small and cysteine-rich proteins present in snake venoms and can interact with specific integrins to inhibit their activities in cell-cell and cell-ECM interactions. These molecules, known to inh
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/11/2018
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2. Efeitos de uma desintegrina RGD recombinante de Rhinocerophis alternatus (Bothrops alternatus) na migração de células normais e tumorais
Cell migration, invasion of the surrounding tissues, blood vessels and proliferation are cellular processes involved in metastases. These events are mediated by integrins, adhesion receptors present on cell surfaces and responsible for the extracellular matrix and cells binding. Disintegrins, snake venoms polypeptides, are known to inhibit integrins action,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/08/2011
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3. Produção recombinante e caracterização de uma desintegrina da peçonha de Rhinocerophis alternatus (antiga Bothrops alternatus) com atividade antimetastática visando o desenvolvimento de um novo fármaco
This work presents the study of the effects of an RGD disintegrin from Rhinocerophis alternatus (ancient Bothrops alternatus) in key steps of the metastatic cascade. Disintegrins are cysteine-rich peptides, which have several biological activities related to cell-cell interaction and cell adhesion. The correct pairing of disulfide bonds exposes the adhesive
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/06/2011
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4. Imunobiologia das infestações de bovinos pelo carrapato Rhipicephalus (Boophilus) microplus: estudo dos correlatos imunes de resistência e de susceptibilidade / The immunobiology of infestations with the cattle tick Rhipiceplahus (Boophilus) microplus: comparative immunologic and molecular studies of the tick-host interface in susceptible and resistant bovine hosts.
The skin of vertebrates is the largest for over 15,000 species of hematophagous arthropods. Among them are ticks, which are long-term feeders and interact with host defenses for days to weeks. Little is known about specialized strategies for eliminating ectoparasites, but ticks can induce immune responses in host. Bovines present variable and heritable level
Publicado em: 2009
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5. Biochemical and biophysical studies of metalloproteinases/disintegrins from snake venom / Estudos bioquímicos e biofísicos de metaloproteinases/desintegrinas de venenos de serpentes
Metalloproteinases/disintegrin (MD) isolated from snake venom are potent inhibitors of platelet aggregation and cell adhesion, processes involved in illnesses as cancer and thrombosis. MD belong to the PIII class of the metalloproteinase/disintegrin gene family and they are constituted by three domains: the catalytic domain, metalloprotease; disintegrin-like
Publicado em: 2008
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6. Otimização da purificação e caracterização adicional de uma desintegrina-RGD recombinante de Bothrops alternatus e seu efeito em células endoteliais humanas (HUVEC).
Disintegrins are snake venom protein, of low molecular weight, rich in cysteines and RGDcontaining peptides that bind specifically to integrins αIIbβ3, α5β1, and αvβ3 expressed on platelets, endothelial and tumor cells. The biological effects of these peptides are related with biological process of cellular adhesion where recept
Publicado em: 2006
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7. Disintegrins: integrin selective ligands which activate integrin-coupled signaling and modulate leukocyte functions
Extracellular matrix proteins and cell adhesion receptors (integrins) play essential roles in the regulation of cell adhesion and migration. Interactions of integrins with the extracellular matrix proteins lead to phosphorylation of several intracellular proteins such as focal adhesion kinase, activating different signaling pathways responsible for the regul
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-10
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8. Caracterização de disintegrinas de venenos viperídeos como ferramentas seletivas na detecção ou inibição da função de integrinas / Characterization of viper venom disintegrins as tools for detecting and inhibiting integrin function
Integrins are membrane proteins involved in biological processes such as embriogenesis, inflammation and platelet aggregation. The alteration of their expression pattem is related to pathological disorders such as thrombosis and cancer, making integrins suitable indicators of the progression of these diseases. Thus, the α2β1 integrin, which is expr
Publicado em: 2003
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9. "Caracterização do Efeito da Jacaragina sobre a Produção e Liberação de Citocinas Pró-inflamatórias em Modelo Murino". / Effect of jararhagin on the production and release of pro-inflammatory cytokies in a murine model.
The inflammatory effect of jararhagin, a haemorrhagic toxin from Bothrops jararaca venom, was evaluated in an in vitro (Murine Peritoneal Adherent Cells-MPACs) and in vivo system (mouse footpad), through the production of TNF-a, IL-1b and IL-6 mRNA (RT-PCR) and the release of these cytokines in the culture supernatant and locally at the site of injection (EL
Publicado em: 2002
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10. A family of cellular proteins related to snake venom disintegrins.
Disintegrins are short soluble integrin ligands that were initially identified in snake venom. A previously recognized cellular protein with a disintegrin domain was the guinea pig sperm protein PH-30, a protein implicated in sperm-egg membrane binding and fusion. Here we present peptide sequences that are characteristic for several cellular disintegrin-doma
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11. Salivary gland extracts from the deerfly contain a potent inhibitor of platelet aggregation.
Salivary gland extracts of the deerfly contain a potent inhibitor of platelet aggregation, which assists the insect in obtaining a blood meal. The extract prevents platelet aggregation induced by ADP, thrombin, and collagen and inhibits fibrinogen binding to the glycoprotein IIb/IIIa receptor on platelets. The active component in deerfly salivary gland extra
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12. Rotavirus contains integrin ligand sequences and a disintegrin-like domain that are implicated in virus entry into cells
Rotavirus contains two outer capsid viral proteins, the spike protein VP4 and major capsid component VP7, both of which are implicated in cell entry. We show that VP4 and VP7 contain tripeptide sequences previously shown to act as recognition sites for integrins in extracellular matrix proteins. VP4 contains the α2β1 integrin ligand site DGE. In VP7, the �
The National Academy of Sciences of the USA.