Discovery
Mostrando 1-12 de 2633 artigos, teses e dissertações.
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1. A carbamazepina é efetiva no tratamento da neuralgia do trigêmeo?
Sim. Carbamazepina e oxcarbazepina são drogas de primeira escolha no tratamento da neuralgia do trigêmeo e oferecem controle inicial significativo da dor em quase 90% dos pacientes. Possuem o mesmo mecanismo de ação, o bloqueio do canal de sódio voltagem-dependente de forma dependente da frequência, resultando na estabilização de membranas neurais
Núcleo de Telessaúde Santa Catarina. Publicado em: 12/06/2023
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2. Synthesis and Evaluation of Antibacterial Activity of 1,2,3-Triazole and Ether Derivatives of Paeonol
Multi-drug-resistant bacteria (MDR) are the cause of different infections and diseases that have affected humanity for a long time, and have been an emerging global health problem that has led to increased morbidity and mortality. The growing emergence of MDR bacteria has underlined the need for development and discovery of new antibacterial compounds. In th
Journal of the Brazilian Chemical Society. Publicado em: 2023
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3. ARTEMISININA E DERIVADOS: DESCOBERTA, ESTRATÉGIAS SINTÉTICAS E OBTENÇÃO INDUSTRIAL
Artemisinin, a natural sesquiterpene isolated from the Artemisia annua L. plant, represents a remarkable achievement in the treatment against malaria. Since its discovery in the 1970’s, researchers readily started synthesizing this complex natural product containing an unusual endoperoxide fragment. Despite various total syntheses reported, only in the las
Química Nova. Publicado em: 2022
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4. Revisiting the History of Chagas Disease: "Live to tell"
Abstract In 1907, Carlos Chagas was designated to fight paludism in the Rio das Velhas region along the Central do Brasil railroad. During his field research, Chagas discovered a hematophagous insect ( Panstrongylus megitus ) carrying a new trypanosomatide, which he named Trypanosoma cruzi . On April 14th, 1909, he found the same parasite in the blood of a f
International Journal of Cardiovascular Sciences. Publicado em: 2022
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5. REFLEXIVITY, ROLE CONFLICTS, AND THE MEANING OF ENGLISH SELF PRONOUNS
Abstract This study offers an innovative, sign-based analysis of English self pronouns (myself, yourself, herself, etc.). While rejecting the traditional characterization of these forms as reflexive pronouns, the study borrows from the tradition by analyzing these forms as a kind of emphatic pronoun. The forms’ distribution can be explained by positing tha
Manuscrito. Publicado em: 2022
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6. Discovery of Thiopyrimidinone Derivatives as a New Class of Human Aldose Reductase Inhibitors
Diabetes is a chronic metabolic disorder characterized by insufficient insulin production, the cells’ inability to use this insulin, or a combination of both, leading to secondary complications such as diabetic neuropathy and retinopathy. One way to prevent or control such complications is the use of aldose reductase (AR) inhibitors. In this work, we synth
Journal of the Brazilian Chemical Society. Publicado em: 2022
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7. In silico prediction of inhibitory potential of a punicalagin β-anomer against SARS-COV-2 main protease (MPRO)
The pandemic caused by the new coronavirus has resulted in a global health emergency and has prompted an urgent need for new treatment strategies. No target-specific drugs are currently available for SARS-CoV-2, but new drug candidates targeting the viral replication cycle are being explored. A prime target of drug-discovery efforts is the SARS-CoV-2 main pr
Química Nova. Publicado em: 2022
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8. Prognostic Factors and Management of Colorectal Gastrointestinal Stromal Tumors
Abstract Introduction The gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. Even though it can be found in any location of the digestive tract, the colorectal GIST is rare. With this study, we aim to review the current knowledge regarding the prognosis and management of colorectal GIST. Methods A
Journal of Coloproctology (Rio de Janeiro). Publicado em: 2022
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9. Does mismatch negativity have utility for NMDA receptor drug development in depression?
Rapid antidepressant effects associated with ketamine have shifted the landscape for the development of therapeutics to treat major depressive disorder (MDD) from a monoaminergic to glutamatergic model. Treatment with ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, may be effective, but has many non-glutamatergic targets, and clinical and logis
Brazilian Journal of Psychiatry. Publicado em: 2022
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10. Three-dimensional cell culture for the study of nasal polyps
Abstract Objectives: Three-dimensional (3D) cell cultures have many applications such as stem cell biology research, new drug discovery, cancer, and Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). This disease is characterized by a significant impact on quality of life and productivity. The diversity of factors that act in the progression of CRSwNP point
Brazilian Journal of Otorhinolaryngology. Publicado em: 2022
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11. The diffusion of innovations under normative induction in Brazil
Abstract Purpose Hierarchically superior bodies develop normative instructions to induce the diffusion of innovations, stimulating the adoption of management practices in supervised public bodies and seeking public administration efficiency increase. Despite this, the effectiveness of these normative instructions is unknown, as well as its inducing and last
RAUSP Management Journal. Publicado em: 2022
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12. Trifecta achievement in patients undergoing partial nephrectomy: a systematic review and meta-analysis of predictive factors
ABSTRACT Purpose The predictors of trifecta achievement in partial nephrectomy (PN) were poorly inquired and remained a controversial area of discovery. To evaluate predictive factors of trifecta achievement in patients undergoing PN. Materials and Methods A systematic literature search was performed to identify relevant articles. Only studies focusing o
International braz j urol. Publicado em: 2022