Prognostic Factors and Management of Colorectal Gastrointestinal Stromal Tumors

AUTOR(ES)

Reis, Nuno Rafael Pereira; Barbosa, Laura Elisabete Ribeiro

FONTE

Journal of Coloproctology (Rio de Janeiro)

DATA DE PUBLICAÇÃO

2022

RESUMO

Abstract Introduction The gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. Even though it can be found in any location of the digestive tract, the colorectal GIST is rare. With this study, we aim to review the current knowledge regarding the prognosis and management of colorectal GIST. Methods A literature search was conducted in PubMed, and 717 articles were collected. After analyzing these studies, 60 articles were selected to use in this review. Results The mitotic index, as well as tumor size and location were identified as good discriminators of prognosis in various studies. Surgery remains the only curative therapy for potentially resectable tumors. However, even after surgical resection, some patients develop disease recurrence and metastasis, especially those with highrisk tumors. Therefore, surgical resection alone might be inadequate for the management of all colorectal GISTs. The discovery of GIST’s molecular pathway led to a shift in its therapy, insofar as tyrosine kinase inhibitors became part of the treatment schemes for this tumor, revolutionizing the treatment’s outcome and prognosis. Discussion/Conclusion The controversy concerning colorectal GIST prognosis and treatment can be, in part, attributed to the limited number of studies in the literature. In this review, we gathered the most recent knowledge about the prognosis and management of GIST in this rare location and propose two algorithms for its approach. Lastly, we highlight the importance of an individualized approach in the setting of a multidisciplinary team.

Documentos Relacionados

• Prognostic factors influencing survival in gastrointestinal leiomyosarcomas. Implications for surgical management and staging.
• Ovarian Sertoli-Leydig Cell Tumors: Epidemiological, Clinical and Prognostic Factors
• Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase
• Prognostic factors after cryotherapy for hepatic metastases from colorectal cancer.
• Surgical management and prognostic factors in patients with subungual melanoma.