Dereplication
Mostrando 1-12 de 16 artigos, teses e dissertações.
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1. Dereplication of Aporphine Alkaloids by UHPLC-HR-ESI-MS/MS and NMR from Duguetia lanceolata St. -Hil (Annonaceae) and Antiparasitic Activity Evaluation
Although the genus Duguetia is well known for producing alkaloids as chemical constituents, there are no reports of alkaloids identified in the species D. lanceolata. Thus, aiming to identify the chemical composition of this species, the dereplication of alkaloidic phase was performed by use of ultra-high performance liquid chromatography high resolution ele
J. Braz. Chem. Soc.. Publicado em: 2020-09
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2. Metabolomics-Based Discovery of Biomarkers with Cytotoxic Potential in Extracts of Myracrodruon urundeuva
Myracrodruon urundeuva (“aroeira-do-sertão”) is a species threatened with extinction due to anthropogenic exploitation. Phytochemical analysis of bark, branch and leaf extracts revealed the presence of several compounds such as flavonoids, phenols, tannins, quercetin derivatives and anacardic acids. Dereplication methodology was performed to tentatively
J. Braz. Chem. Soc.. Publicado em: 2020-04
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3. Integrative Approach Based on Leaf Spray Mass Spectrometry, HPLC-DAD-MS/MS, and NMR for Comprehensive Characterization of Isoquinoline-Derived Alkaloids in Leaves of Onychopetalum amazonicum R. E. Fr.
Onychopetalum is an Amazonian botanical genus close-related with Bocageopsis and Unonopsis, whose species are used in traditional medicine. Although these genera are widely investigated from the phytochemical viewpoint, the knowledge about Onychopetalum remains almost unexplored. In order to perform a comprehensive characterization of isoquinoline-derived al
J. Braz. Chem. Soc.. Publicado em: 2020-01
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4. Neolignans isolated from twigs of Nectandra leucantha Ness & Mart (Lauraceae) displayed in vitro antileishmanial activity
Abstract Background: The therapeutic arsenal for the treatment of Leishmaniasis is limited and includes toxic compounds (antimonials, amphotericin B, pentamidine and miltefosine). Given these aspects, the search for new compounds based on floristic biodiversity is crucial. In the present work, we report the isolation, characterization and antileishmanial ac
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 18/10/2018
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5. Chemical Constituents of Psychotria nemorosa Gardner and Antinociceptive Activity
Through dereplication strategies using gas chromatography-mass spectrometry (GC-MS) and ultra fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS), the ethanol extract from Psycotria nemorosa leaves (Rubiaceae) showed to be composed of: cinnamic acid, dihydroactinidiolide, 4-hydroxy-β-ionone, phytol, isophytol, 4,8,12,16-tetramethylheptadecan-4-
J. Braz. Chem. Soc.. Publicado em: 2017-05
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6. Chemical characterization of two morphologically related Espeletia (Asteraceae) species and chemometric analysis based on essential oil components
ABSTRACT In this study, a comprehensive phytochemical characterization of two morphologically related species from the genus Espeletia Mutis ex Bonpl., namely, Espeletia grandiflora Humb. & Bonpl. and Espeletia killipii Cuatrec., Asteraceae, has been performed by gas chromatography coupled to flame ionization detection, gas chromatography coupled to mass spe
Rev. bras. farmacogn.. Publicado em: 2016-12
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7. New Dereplication Method Applied to NMR-Based Metabolomics on Different Fusarium Species Isolated from Rhizosphere of Senna spectabilis
The search for new sources of natural products steadily increased the use of bioinformatic tools that enabled efficient analysis of complex matrices. In this context, dereplication methods emerged as a fast way of identifying known compounds, accelerating the identification of bioactive chemotypes. Although 1H NMR is widely used as an analytical technique, f
J. Braz. Chem. Soc.. Publicado em: 2016-08
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8. Dereplication of phenolic derivatives of Qualea grandiflora and Qualea cordata (Vochysiaceae) using liquid chromatography coupled with ESI-QToF-MS/MS
Um método racional e seletivo de cromatografia de alta eficiência acoplado à espectrometria de massas (CLAE-EM) com ionização por electrospray e analisador do tipo quadrupolo em tempo-de-voo em sequência (ESI-QToF-MS/MS) foi desenvolvido para a desreplicação de derivados fenólicos presentes em Qualea grandiflora e Qualea cordata. Os extratos para a
J. Braz. Chem. Soc.. Publicado em: 2013-05
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9. Desreplicação de alcaloides aporfínicos e oxoaporfínicos de Unonopsis guatterioides por ESI-IT-MS
The dereplication of aporphine and oxoaporphine alkaloids by direct infusion in ESI-IT-MSn system was applied for alkaloidal fractions of the Unonopsis guatterioides (Annonaceae). Its main advantage over other dereplication methods is the ability to quickly identify substances in complex mixtures without the use of coupled techniques and expensive databases.
Química Nova. Publicado em: 2012
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10. Solanum campaniforme: chemical constituents, fragmentation study and dereplication by electrospray mass spectrometry (ESI-MS/MS) / Solanum campaniforme: constituintes quÃmicos, estudo de fragmentaÃÃo e desreplicaÃÃo por espectrometria de massas com ionizaÃÃo por electrospray (IES-EM/EM)
Este trabalho descreve o estudo fitoquÃmico de Solanum campaniforme (Solanaceae), visando o isolamento e elucidaÃÃo estrutural de novos constituintes quÃmicos bioativos, bem como o estudo do padrÃo de fragmentaÃÃo por espectrometria de massas seqÃencial com ionizaÃÃo por electrospray (IES-EM/EM) dos alcalÃides obtidos. A investigaÃÃo quÃmica re
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/11/2011
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11. Estratégias de desreplicação aplicadas ao estudo da planta Alternanthera brasiliana e dos fungos endofíticos associados / Studies towards the dereplication of antibiotic constituents in Alternanthera brasiliana and associated microorganisms
A planta Alternanthera brasiliana é popularmente conhecida por suas diversas atividades biológicas. Assim, o presente trabalho pretende contribuir com o uso de estratégias de desreplicação a fim de estabelecer uma correlação entre os compostos químicos presentes nesta planta e a atividade antibiótica associada a ela. Além disso, essas estratégias
Publicado em: 2011
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12. Aplicação da espectrometria de massas na derreplicação de extratos brutos produzidos por actinobactérias isoladas da rizosfera do milho (Zea mays L.) / Mass spectrometry applied to the dereplication of crude extracts from rhizosphere actinomycetes
O objetivo deste trabalho é isolar e identificar os compostos que apresentem atividade fitotóxica presente nos extratos produzidos por actinobactérias isoladas da rizosfera do milho. Para isso foram realizados estudos de derreplicação, baseados nas informações estruturais obtidas por diversas técnicas analíticas. Em especial foi aplicada a espectrom
Publicado em: 2009