Chemical Constituents of Psychotria nemorosa Gardner and Antinociceptive Activity
AUTOR(ES)
Calixto, Nivea O., Cordeiro, Millena S., Giorno, Thais B. S., Oliveira, Gibson G., Lopes, Norberto P., Fernandes, Patricia D., Pinto, Angelo C., Rezende, Claudia M.
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2017-05
RESUMO
Through dereplication strategies using gas chromatography-mass spectrometry (GC-MS) and ultra fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS), the ethanol extract from Psycotria nemorosa leaves (Rubiaceae) showed to be composed of: cinnamic acid, dihydroactinidiolide, 4-hydroxy-β-ionone, phytol, isophytol, 4,8,12,16-tetramethylheptadecan-4-olide, lupeol, a mixture of α/β-amyrin, the keto and acetylated derivatives, besides stigmast-4-en-3-one, campesterol, stigmasterol and γ-sitosterol by GC-MS. Likewise, by UFLC-MS/MS, the main compounds identified were: butin, resveratrol, rutin, kaempferol 7-O-β-D-glucopyranoside, deacetylasperuloside, epiloganin, hordenine, strictosidine, N-methyl-1,2,3,4-tetrahydro-β-carboline and N-formyl-tryptamine. The antinociceptive activity of the crude extract ant its fractions was reported.
Documentos Relacionados
- Psychotria viridis: Chemical constituents from leaves and biological properties
- Alkaloid and other chemical constituents from Psychotria stachyoides Benth.
- Chemical constituents of Lecythis pisonis and cytotoxic activity
- Salacia crassifolia (Celastraceae): CHEMICAL CONSTITUENTS AND ANTIMICROBIAL ACTIVITY
- Chemical constituents and leishmanicidal activity from leaves of Kielmeyera variabilis