Deoxycholic Acid
Mostrando 1-12 de 43 artigos, teses e dissertações.
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1. Secondary bile acids effects in colon pathology. Experimental mice study
ABSTRACTPURPOSE:To assess whether deoxycholic acid (DOC) and lithocholic acid (LCA) administered in a period of six months in a concentration of 0.25% may have a carcinogenic role in mice colon.METHODS:The study used C57BL6 female mice divided into four groups. The control group received a balanced diet and the others received diets supplemented with 0.25% D
Acta Cir. Bras.. Publicado em: 2015-09
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2. Chá mate (Ilex paraguariensis): compostos bioativos e relação com atividade biológica / Mate tea (Ilex paraguariensis): bioactive compounds and relationship with biological activity
Introduction: Yerba maté (Ilex paraguariensis St. Hilaire) is a spontaneous species that grows in Brazil, Argentina and Paraguay and several beverages (chimarrão, terere, maté tea) are produced from its leaves. Maté tea, one of I. paraguariensis beverages present antioxidant activity and other biological effects. Compounds such as aponins, polyphenols an
Publicado em: 2009
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3. Desenvolvimento de mÃtodos analÃticos rÃpidos e de baixo custo utilizando ciclodextrinas para o controle de qualidade de fÃrmacos
O Ãcido desoxicÃlico (DCA) e o Ãcido ursodesoxicÃlico (UDCA) sÃo Ãcidos biliares com inÃmeras aplicaÃÃes farmacÃuticas, no entanto, as metodologias empregadas para determinaÃÃo de suas concentraÃÃes sÃo demoradas e onerosas. Neste trabalho foram usadas as ciclodextrinas, oligossacarÃdeos cÃclicos, que tÃm a capacidade de formar complexos de
Publicado em: 2009
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4. Bioatividade do grão de amaranto : avaliação in vitro da atividade ligante de acidos biliares e inibidora da enzima conversora de angiotensina. / Bioactivity of the amaranth grain : in vitro assessment of the binding bile acids and inihibitory activity of the angiotensin converting enzyme.
Amaranth has been highlighted as an excellent alternative or complementary source of food protein due to its balanced amino acid composition. The culture of amaranth has been introduced into Brazil on account of its optimum nutritional (high protein content and better biological quality than that of cereal protein) and functional quality, apart from its agri
Publicado em: 2007
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5. Absence of transformation of beta-muricholic acid by human microflora implanted in the digestive tracts of germfree male rats.
Germfree rats biosynthetize cholic and beta-muricholic acids. The latter does not exist in humans. Germfree rats were given human fecal suspensions. These rats degraded cholic acid into deoxycholic acid but failed to metabolize beta-muricholic acid.
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6. Increased formation of ursodeoxycholic acid in patients treated with chenodeoxycholic acid.
The formation of ursodeoxycholic acid, the 7 beta-hydroxy epimer of chenodeoxycholic acid, was investigated in three subjects with cerebrotendinous xanthomatosis and in four subjects with gallstones. Total biliary bile acid composition was analyzed by gas-liquid chromatography before and after 4 months of treatment with 0.75 g/day of chenodeoxycholic acid. I
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7. Bile acid inhibition of Clostridium botulinum.
Bile acids and their glycine and taurine conjugates were tested in vitro for inhibition of Clostridium botulinum types A and B. Cholic acid inhibited most strains at 2 mg/ml, whereas chenodeoxycholic acid inhibited all strains at 0.4 mg/ml. Deoxycholic acid inhibited one strain at 0.08 mg/ml and other strains at 0.4 and 2 mg/ml. Lithocholic acid inhibited al
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8. Hepatic and extrahepatic glucuronidation of bile acids in man. Characterization of bile acid uridine 5'-diphosphate-glucuronosyltransferase in hepatic, renal, and intestinal microsomes.
Microsomal UDP-glucuronosyltransferase activity toward the bile acids (chenodeoxycholic, deoxycholic, ursodeoxycholic, lithocholic, and glycolithocholic) has been detected in human specimens of liver, kidney, and intestinal mucosa. The characteristics of hepatic and extrahepatic UDP-glucuronosyltransferase activities toward these bile acids were compared wit
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9. Serum bile acids in patients with hyperlipidaemia.
Individual serum bile acids were analysed by an improved gas liquid chromatography method in 12 patients with primary hyperlipidaemia. Total serum bile acid concentrations were raised in 10 subjects. Ursodeoxycholic acid was found in all 12 patients. It was present in significantly greater concentrations, accounted for a greater proportion of the total serum
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10. Deoxycholic Acid Activates β-Catenin Signaling Pathway and Increases Colon Cell Cancer Growth and Invasiveness
Colorectal cancer is often lethal when invasion and/or metastasis occur. Tumor progression to the metastatic phenotype is mainly dependent on tumor cell invasiveness. Secondary bile acids, particularly deoxycholic acid (DCA), are implicated in promoting colon cancer growth and progression. Whether DCA modulates β-catenin and promotes colon cancer cell growt
The American Society for Cell Biology.
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11. Hepatic Uptake of Bile Acids in Man: FASTING AND POSTPRANDIAL CONCENTRATIONS OF INDIVIDUAL BILE ACIDS IN PORTAL VENOUS AND SYSTEMIC BLOOD SERUM
This investigation was undertaken in order to (a) characterize the postprandial inflow of individual bile acids to the liver and (b) determine if peripheral venous bile acid levels always adequately reflect the portal venous concentration, or if saturation of hepatic bile acid uptake can occur under physiological conditions. In five patients with uncomplicat
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12. Absorption of bile acids from the large bowel in man
The absorption of bile acids from the human large bowel was studied in eight patients. All patients had cholecystitis and cholelithiasis and had to undergo cholecystectomy. Cholic acid-14C was injected during surgery into the lumen of the cecum, hepatic flexure of the colon, or transverse colon in six patients, under the visual control of the surgeon. Common