Damage Repair
Mostrando 1-12 de 1613 artigos, teses e dissertações.
-
1. “Zooming” in strategies and outcomes for trauma cases with Injury Severity Score (ISS) ≥16: promise or passé?
SUMMARY OBJECTIVE: Rescuing severe trauma cases is extremely demanding. The present study purposed to analyze the efficiency of trauma management at Emergency Centre, University Clinical Centre of Serbia, Belgrade, included outcome within 28 days. METHODS: This retrospective study involved 131 intensive care unit trauma cases with total Injury Severity Sco
Revista da Associação Médica Brasileira. Publicado em: 2022
-
2. The association between the histopathological features and microsatellite instability in young patients with urothelial carcinoma of the bladder
SUMMARY OBJECTIVE: Bladder cancer under the age of 40 is extremely rare. Bladder cancer development involves complex and multi-stage processes, one of which is the DNA damage repair mechanism. In this retrospective study, we aimed to evaluate the histopathological features of bladder urothelial carcinoma seen in patients under 40 years of age and tumor micr
Rev. Assoc. Med. Bras.. Publicado em: 2021-01
-
3. THE LACK OF ECONOMIC ENVIRONMENTAL DAMAGE VALUATION - A CRITICAL REVIEW OF FUNDÃO DISASTER
ABSTRACT Critical events such as the disruption of the Fundão tailings dam, considered the biggest technological disaster in Brazil and the biggest of its category in the world, test the responsiveness of organizations in charge of protecting the environment. In the process of assign liability for damage, lawsuits initially proposed were replaced by settlem
CERNE. Publicado em: 2020-03
-
4. DNA repair genes in astrocytoma tumorigenesis, progression and therapy resistance
Abstract Glioblastoma (GBM) is the most common and malignant type of primary brain tumor, showing rapid development and resistance to therapies. On average, patients survive 14.6 months after diagnosis and less than 5% survive five years or more. Several pieces of evidence have suggested that the DNA damage signaling and repair activities are directly correl
Genet. Mol. Biol.. Publicado em: 13/12/2019
-
5. ADP-ribosylation: from molecular mechanisms to human disease
Abstract Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribos
Genet. Mol. Biol.. Publicado em: 13/12/2019
-
6. Exosomes secreted from miRNA-29b-modified mesenchymal stem cells repaired spinal cord injury in rats
Exosomes, a kind of extracellular vesicle, are promising therapeutic agents for spinal cord injury (SCI). This article aimed to investigate effects of exosomes secreted from miRNA-29b-modified bone marrow mesenchymal stem cells (BMSCs) on SCI. Exosomes were extracted from BMSCs transfected with miRNA-29b or negative control (miR NC). SCI rats were injected i
Braz J Med Biol Res. Publicado em: 05/12/2019
-
7. Deoxyribonucleic acid damage and repair response in the chemotherapy of lung cancer: cross-sectional study
Abstract: This study evaluated 24 patients with lung cancer (CA) and 23 individuals with no smoking history or cancer in the family and without respiratory disease in childhood (CO). Peripheral blood lymphocytes was used to perform alkaline comet assay and to assess DNA damage as well as to evaluate methyl methane sulfonate (MMS) DNA repair after one hour an
An. Acad. Bras. Ciênc.. Publicado em: 30/09/2019
-
8. Endothelial progenitor cells and vascular endothelial growth factor in patients with Takayasu's arteritis
Abstract Background: Endothelial progenitor cells (EPCs) are responsible for endothelial damage repair. Takayasu's arteritis (TA) is a chronic inflammatory disease that affects large vessels. The aim of the study was to evaluate the number of EPCs and the levels of vascular endothelial growth factor (VEGF) and the relationship of these variables in patients
Adv. rheumatol.. Publicado em: 29/07/2019
-
9. Study of cracks in concrete target under deep penetration by a projectile
Abstract A large number of cracks occur in concrete structure after projectile penetration. The study of crack distribution and propagation process is the basis of damage assessment, structural repair and high dynamic fracture mechanism. In this paper, wire saw cutting, X-ray computed tomography (X-CT) and mechanical property testing of damaged concrete were
Lat. Am. j. solids struct.. Publicado em: 14/03/2019
-
10. Explaining transgressions with moral disengagement strategies and their effects on trust repair
Abstract When providing explanations for a transgression, the offender may use verbal statements based on moral disengagement strategies to mitigate the negative consequences of a trust violation. That is, the offender may try to reframe unethical acts to appear less harmful, or displace responsibility for the wrongdoing, or distort the consequences of his o
BAR, Braz. Adm. Rev.. Publicado em: 21/01/2019
-
11. DNA repair pathways and cisplatin resistance: an intimate relationship
The main goal of chemotherapeutic drugs is to induce massive cell death in tumors. Cisplatin is an antitumor drug widely used to treat several types of cancer. Despite its remarkable efficiency, most tumors show intrinsic or acquired drug resistance. The primary biological target of cisplatin is genomic DNA, and it causes a plethora of DNA lesions that block
Clinics. Publicado em: 06/09/2018
-
12. Human papillomavirus and genome instability: from productive infection to cancer
Infection with high oncogenic risk human papillomavirus types is the etiological factor of cervical cancer and a major cause of other epithelial malignancies, including vulvar, vaginal, anal, penile and head and neck carcinomas. These agents affect epithelial homeostasis through the expression of specific proteins that deregulate important cellular signaling
Clinics. Publicado em: 06/09/2018