Cyproterone Acetate
Mostrando 1-12 de 15 artigos, teses e dissertações.
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1. Removal of synthetic sex hormones by hydrothermal carbonization
ABSTRACT One of the most prominent fields of environmental chemistry is the study and the removal of micro-pollutants from aqueous matrices. Analytical techniques for their identification and quantification are becoming more sensitive and comprehensive and, as a result, an increasing number of drugs have been detected in environmental samples. However, the l
An. Acad. Bras. Ciênc.. Publicado em: 14/05/2018
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2. Low estrogen doses normalize testosterone and estradiol levels to the female range in transgender women
OBJECTIVE: The ideal dosage of cross-sex hormones remains unknown. The aim of this study was to evaluate the luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol and prolactin levels after low-dose estrogen therapy with or without cyproterone acetate in transgender women. METHODS: The serum hormone and biochemical profiles of 51 trans
Clinics. Publicado em: 03/05/2018
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3. Bioequivalence study of two formulations with 2 mg of cyproterone acetate and 0,35 mg ethynilestradiol in healthy volunteers by high-performance liquid coupled to mass spectrometry / Estudo de bioequivalencia entre duas formulações contendo 2 mg de acetato de ciproterona e 0,035 mg de etinilestradiol em voluntarias sadias atraves de cromatografia liquida acoplada a espectrometria de massas
O objetivo deste estudo foi avaliar a bioequivalência de duas formulações de acetato de ciproterona e etinilestradiol em drágea vs comprimido (Selene® comprimidos, Laboratório Eurofarma Ltda., formulação Teste e Diane® 35, Schering do Brasil, como Referência) após administração oral em 48 voluntárias adultas sadias. O estudo foi do tipo aberto,
Publicado em: 2008
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4. A prostata ventral do gerbilo frente as diferentes formas de castração e subsequente reposição hormonal pela testosterona
The prostate is an exocrine gland of the male genital system, which secretes part of seminal liquidolts differentiation initiates in the beginning of the embryonic development and finishes during the puberty. Testosterone (T) plays an essential role in prostate maintenance, after transformation, by 5a-reductase enzyme, to dehidrotestostorone (DHT) an more po
Publicado em: 2005
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5. Effect of cyproterone acetate on alpha1-adrenoceptor subtypes in rat vas deferens
Gonadal hormones regulate the expression of alpha1-adrenoceptor subtypes in several tissues. The present study was carried out to determine whether or not cyproterone acetate, an anti-androgenic agent, regulates the alpha1-adrenoceptor subtypes that mediate contractions of the rat vas deferens in response to noradrenaline. The actions of subtype selective al
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-11
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6. Diane-35 (cyproterone acetate): safety concerns
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7. Lobar collapse due to endobronchial metastatic prostatic carcinoma: re-expansion with antiandrogen treatment.
A patient is described who presented with left upper lobe collapse due to endobronchial metastatic prostate carcinoma. Treatment with the oral antiandrogen cyproterone acetate resulted in resolution of the occluding endobronchial carcinoma and lobar re-expansion.
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8. Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells
Although hormone therapy with antiandrogens has been widely used for the treatment of prostate cancer, some antiandrogens may act as androgen receptor (AR) agonists that may result in antiandrogen withdrawal syndrome. The molecular mechanism of this agonist response, however, remains unclear. Using mammalian two-hybrid assay, we report that antiandrogens, hy
The National Academy of Sciences.
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9. A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer
In addition to the classical activation by ligands, nuclear receptor activity is also regulated by ligand-independent signalling. Here, we unravel a novel signal transduction pathway that links the RhoA effector protein kinase C-related kinase PRK1 to the transcriptional activation of the androgen receptor (AR). Stimulation of the PRK signalling cascade res
Oxford University Press.
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10. The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells
Down-regulation of the androgen receptor (AR) is being evaluated as an effective therapy for the advanced stages of prostate cancer. We report that Ebp1, a protein identified by its interactions with the ErbB3 receptor, down-regulates expression of AR and AR-regulated genes in the LNCaP prostate cancer cell line. Using microarray analysis, we identified six
National Academy of Sciences.
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11. Why do winners keep winning? Androgen mediation of winner but not loser effects in cichlid fish
Animal conflicts are influenced by social experience such that a previous winning experience increases the probability of winning the next agonistic interaction, whereas a previous losing experience has the opposite effect. Since androgens respond to social interactions, increasing in winners and decreasing in losers, we hypothesized that socially induced tr
The Royal Society.
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12. Steroid-induced epithelial-fibroblastic conversion associated with syndecan suppression in S115 mouse mammary tumor cells.
Cell-matrix interactions play an important role in the maintenance of cell shape, supposed to be mediated by the anchorage of cellular cytoskeleton to extracellular matrix via matrix receptors. In this work the expression of one of the known matrix receptors, syndecan, was studied during the hormone-induced change in the phenotype of Shionogi 115 (S115) mous