Cyclosporin A
Mostrando 1-12 de 457 artigos, teses e dissertações.
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1. Omalizumab versus cyclosporin-A for the treatment of chronic spontaneous urticaria: can we define better-responding endotypes?
Abstract Background: Chronic Spontaneous Urticaria (CSU) is characterized by recurrent wheals and/or angioedema for longer than 6-weeks. Guidelines recommend Omalizumab (Oma) as first-line and Cyclosporine-A (Cs-A) as second-line treatment in antihistamine resistant CSU. This step-wise algorithm might be time-consuming and costly. Objective: To determine i
Anais Brasileiros de Dermatologia. Publicado em: 2022
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2. Effects of cyclosporin, nifedipine and phenytoin on gingival myofibroblast transdifferentiation in monkeys
Abstract Objective: Myofibroblasts have been associated with the development of several pathologic fibrotic conditions. This longitudinal study aims to assess the proliferative and antiapoptotic effects of cyclosporin, nifedipine and phenytoin on gingival connective tissue cells of nonhuman primate, as well as to analyze a possible role of myofibroblasts in
J. Appl. Oral Sci.. Publicado em: 08/11/2018
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3. Endothelin-1 receptor antagonists protect the kidney against the nephrotoxicity induced by cyclosporine-A in normotensive and hypertensive rats
Cyclosporin-A (CsA) is an immunosuppressant associated with acute kidney injury and chronic kidney disease. Nephrotoxicity associated with CsA involves the increase in afferent and efferent arteriole resistance, decreased renal blood flow (RBF) and glomerular filtration. The aim of this study was to evaluate the effect of Endothelin-1 (ET-1) receptor blockad
Braz J Med Biol Res. Publicado em: 11/12/2017
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4. Necrolisis epidérmica tóxica: un paradigma de enfermedad crítica
ABSTRACT Toxic epidermal necrolysis is an adverse immunological skin reaction secondary in most cases to the administration of a drug. Toxic epidermal necrolysis, Stevens-Johnson syndrome, and multiform exudative erythema are part of the same disease spectrum. The mortality rate from toxic epidermal necrolysis is approximately 30%. The pathophysiology of tox
Rev. bras. ter. intensiva. Publicado em: 2017-12
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5. The effects of Cyclosporin A and Heteropterys tomentosaon the rat liver
A Ciclosporina A (CsA) é uma droga imunossupressora amplamente utilizada que está associada a diversos efeitos colaterais, dentre eles hepatotoxicidade. Heteropterys tomentosaé uma planta brasileira eficiente na redução dos danos causados pela CsA nos testículos e próstata de ratos. O objetivo deste estudo foi avaliar o efeito da CsA e H. tomentosa(ad
An. Acad. Bras. Ciênc.. Publicado em: 2015-03
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6. Influence of cyclosporine on the occurrence of nephrotoxicity after allogeneic hematopoietic stem cell transplantation: a systematic review
Cyclosporine, a drug used in immunosuppression protocols for hematopoietic stem cell transplantation that has a narrow therapeutic index, may cause various adverse reactions, including nephrotoxicity. This has a direct clinical impact on the patient. This study aims to summarize available evidence in the scientific literature on the use of cyclosporine in re
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-10
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7. Análise de custo-efetividade dos inibidores da rapamicina para o tratamento de imunossupressão no transplante renal
Terminal chronic kidney disease can be treated with hemodialysis (HD), peritoneal dialysis (PD) or by means of renal transplantation. Among these three treatment modalities, the transplant is, according to the literature, the modality that offers better quality of life. Adding to this the progress of the immunosuppressants used in post-transplant, the number
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/06/2012
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8. The role of Ca2+/calmodulin-dependent protein kinase II and calcineurin in TNF-α-induced myocardial hypertrophy
We investigated whether Ca2+/calmodulin-dependent kinase II (CaMKII) and calcineurin (CaN) are involved in myocardial hypertrophy induced by tumor necrosis factor α (TNF-α). The cardiomyocytes of neonatal Wistar rats (1-2 days old) were cultured and stimulated by TNF-α (100 μg/L), and Ca2+ signal transduction was blocked by several antagonists, including
Braz J Med Biol Res. Publicado em: 2012-11
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9. Pharmacokinetics of cyclosporin: a microemulsion in children with idiopathic nephrotic syndrome
OBJECTIVE: We present a prospective study of a microemulsion of cyclosporin to treat idiopathic nephrotic syndrome in ten children with normal renal function who presented cyclosporin trough levels between 50 and 150 ng/ml and achieved complete remission with cyclosporin. To compare the pharmacokinetic parameters of cyclosporin in idiopathic nephrotic syndro
Clinics. Publicado em: 2012-10
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10. Transplantation of mononuclear cells from human umbilical cord blood promotes functional recovery after traumatic spinal cord injury in Wistar rats
Cell transplantation is a promising experimental treatment for spinal cord injury. The aim of the present study was to evaluate the efficacy of mononuclear cells from human umbilical cord blood in promoting functional recovery when transplanted after a contusion spinal cord injury. Female Wistar rats (12 weeks old) were submitted to spinal injury with a MASC
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-01
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11. Eventos moleculares associados ao aumento gengival induzido por ciclosporina A são atenuados pela superexpressão de Smad7 / Molecular events associated with cyclosporin A induced gingival overgrowth are attenuated by Smad 7 overexpression
O aumento gengival induzido por ciclosporina A (CsA) é causado por um acúmulo excessivo de matriz extracelular, resultado da ação do fator de crescimento transformante-beta 1 (TGF-ß1) sobre a atividade dos fibroblastos gengivais. O presente estudo investigou in vitro os efeitos da superexpressão de Smad7, um inibidor da sinalização de TGF-ß1, nos ev
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/07/2011
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12. Efeito da Ciclosporina A associada à infusão de nó-de-cachorro (Heteropterys aphrodisiaca, O. Mach, 1949) na próstata de ratos Wistar / Effect of Cyclosporin A associated with nó-de-cachorro (Heteropterys aphrodisiaca, O. Mach, 1949) infusion on Wistar rats ventral prostate
A Ciclosporina A (CsA) é um imunossupressor amplamente utilizado no tratamento pós-transplante de órgãos e contra doenças auto-imunes. Entretanto, diversos efeitos colaterais estão relacionados ao tratamento com esta droga, dentre eles nefrotoxicidade, hepatoxicidade, tremor, hipertensão, hiperlipidemia, hipercalcemia, hipertricose e hiperplasia gengi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/02/2011