Cyclosporin A
Mostrando 13-24 de 457 artigos, teses e dissertações.
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13. Low prevalence of gingival overgrowth associated to new imunossupressive protocols with cyclosporin
Gingival overgrowth (GO) is a frequent finding in patients treated with cyclosporine (CsA). This study investigated the prevalence and severity of GO in patients who received kidney transplant and CsA therapy, as well as associations with pharmacological and clinical factors. This cross-sectional study included 63 kidney transplant recipients who were treate
Brazilian Oral Research. Publicado em: 01/12/2011
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14. Modification of c and n sources for enhanced production of cyclosporin 'a' by Aspergillus Terreus
Most of the studies regarding cyclosporin 'A' production through fungi concentrate around Tolypocladium inflatum. This is mainly due to lower reported production of this drug in other fungi. The present study was therefore conducted to explore indigenous isolates of Aspergillus terreus for synthesis of this drug and defining a production medium for obtaining
Braz. J. Microbiol.. Publicado em: 2011-12
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15. Avaliação do RANK na periodontite induzida em ratos previamente expostos à Ciclosporina A / Evaluation of RANK induced periodontitis in rats previously exposed to Cyclosporine A
O uso de ciclosporina A (CsA) tem sido associado com aumento na reabsorção óssea como efeito adverso. Porém, há controvérsia sobre quais mecanismos são responsáveis por esta associação. Objetivo: Este estudo investigou o efeito da exposição prévia a CsA sobre a expressão de RANK e perda óssea na periodontite experimental em ratos. Método: Qua
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/09/2010
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16. Some optimal culture conditions for production of cyclosporin a by Fusarium roseum
A suitable chemically defined culture medium was selected and some optimal conditions for the production of the highly immunosuppressive compound, cyclosporin A (Cyc A) are reported. Medium of the following composition was favorable for the production of Cyc A by Fusarium roseum: glucose, 30; NaNO3, 2; KH2PO4, 1; MgSO4.7H2O, 0.5 and KCL, 0.5 (g/l). Maximum p
Brazilian Journal of Microbiology. Publicado em: 2010-12
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17. Effects of sirolimus alone or in combination with cyclosporine A on renal ischemia/reperfusion injury
Calcineurin inhibitors exacerbate ischemic injury in transplanted kidneys, but it is not known if sirolimus protects or exacerbates the transplanted kidney from ischemic injury. We determined the effects of sirolimus alone or in combination with cyclosporin A (CsA) on oxygenated and hypoxic/reoxygenated rat proximal tubules in the following in vitro groups c
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-08
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18. Cyclosporin A-induced gingival overgrowth is not associated with myofibroblast transdifferentiation
Cyclosporin A (CyA) induces gingival overgrowth via its stimulatory effects on expression of transforming growth factor-beta1 (TGF-β1) and collagen. It is not known whether CyA has a direct effect on gingival fibroblasts or induces its effect indirectly via stimulation of myofibroblast transdifferentiation. The present study was undertaken to examine the in
Brazilian Oral Research. Publicado em: 2010-06
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19. AUMENTO GENGIVAL ASSOCIADO À CICLOSPORINA EM TRANSPLANTADOS RENAIS NO HUSM
Background: Gingival enlargement (GE) is a frequent finding in cyclosporin users. The mechanisms of this association are not totally known and point out to a multifactorial model, with dose and associations with calcium channel blockers. Novel immunosuppression protocols are adjusting for drugs and dosages. Aim: This study aimed at investigating the prevalen
Publicado em: 2010
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20. Lymphocyte subpopulations during cytomegalovirus disease in renal transplant recipients
We have determined the number of circulating T, B and natural killer cells in renal transplant recipients in order to detect changes during cytomegalovirus (CMV) infections. Serial blood samples were taken from 61 patients on standard triple immunosuppression therapy (cyclosporin A, azathioprine and prednisone). Using two-color flow cytometry analysis, the a
Publicado em: 2010
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21. Proteção por L-carnitina ou piracetam contra a morte celular causada por sinvastatina em celulas tumorais e não tumorais / Protection by L-carnitine or piracetam against cell death caused by simvastatin in tumor and non tumorigenic cell lines
Statins are drugs widely used in the treatment of hypercholesterolemia. They are competitive inhibitors of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase preventing in this way, the synthesis of cholesterol. L-carnitine is synthesized from the essential aminoacids lysine and methionine in liver and kidney and plays na important role in the cell, w
Publicado em: 2010
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22. Alport syndrome: significance of gingival biopsy in the initial diagnosis and periodontal evaluation after renal transplantation
Alport Syndrome (AS) is an important hereditary disorder affecting the glomerular basement membrane. Diagnosis of AS is based on the presence of hematuric nephropathy, renal failure, hearing loss, ocular abnormalities and changes in the glomerular basement membrane of the lamina densa. The aims of this case report were to show the changes in the gingival tis
Journal of Applied Oral Science. Publicado em: 2009-12
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23. Papel do macrófago na nefrotoxicidade crônica induzida pela ciclosporina A.
The aim of this study was to investigate the role of macrophage, nitric oxide pathway and oxidative stress on chronic cyclosporin (CsA) nephrotoxicity. Methods: Macrophages were depleted by clodronate liposomes (CL). Male rats on a low salt diet, were distributed in 3 groups: vehicle (VH, olive oil), CsA 7.5 mg/Kg/day (CsA, 21 days), or CsA plus CL (CsA-CL,
Publicado em: 2009
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24. Efeito do derivado quinazolinico PD153035 sobre a função mitocondrial : implicações na cardioproteção / Effect of the 4-anilinoquinazoline PD153035 on mitochondrial function : implication in cardioprotection
The action of the aminoquinazoline PD153035 on the mitochondrial functions was investigated. The addition of various PD153035 concentrations (5, 10, 20 and 40 μM) to liver mitochondria decreased the mitochondrial respiratory control, induced mitochondrial permeability transition cyclosporin A-sensitive, increased the mitochondrial calcium uptake capacit
Publicado em: 2008