Cyclodextrins
Mostrando 1-12 de 79 artigos, teses e dissertações.
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1. Imiquimod/β-Cyclodextrin Inclusion Complex: Experimental and Theoretical Studies
Imiquimod (IMQ), an immune response modifier, is used for topical treatment of basal cell carcinoma and actinic keratosis. The very poor aqueous solubility of imiquimod gives rise to difficulties in designing aqueous formulations with this drug. One approach that is widely used to enhance drug solubility is complexation with cyclodextrins. The formation of t
J. Braz. Chem. Soc.. Publicado em: 2020-08
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2. Inclusion complexes and self-assembled cyclodextrin aggregates for increasing the solubility of benzimidazoles
Albendazole and fenbendazole are imidazole derivatives that exhibit broad spectrum activity against parasites, but the low solubility of these drugs considerably reduces their effectiveness. Complexation of albendazole and fenbendazole with cyclodextrins (β-cyclodextrin and hydroxypropyl-β-cyclodextrin) in both water and an aqueous solution of polyvinylpyr
Braz. J. Pharm. Sci.. Publicado em: 25/11/2019
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3. Molecular identification of a cyclodextrin glycosyltransferase-producing microorganism and phylogenetic assessment of enzymatic activities
Abstract: Cyclodextrin glycosyltransferases (CGTases) are important enzymes in the biotechnology field because they catalyze starch conversion into cyclodextrins and linear oligosaccharides, which are used in food, pharmaceutical and cosmetic industries. The CGTases are classified according to their product specificity in α-, β-, α/β- and γ-CGTases. As
An. Acad. Bras. Ciênc.. Publicado em: 07/10/2019
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4. Complexation and enhancement of temozolomide solubility with cyclodextrins
ABSTRACT Temozolomide is a poorly soluble anti-cancer drug used in the treatment of some brain cancers. Following literature reports about the enhancement of solubility and stability for these kinds of drugs upon complexation with cyclodextrins, we aimed to form an inclusion complex between temozolomide and the different types of cyclodextrins (CDs) to enhan
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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5. Antidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeol
ABSTRACT Diarrhea is an infectious disease caused by bacterial, virus, or protozoan, and dengue is caused by virus, included among the neglected diseases in several underdeveloped and developing countries, with an urgent demand for new drugs. Considering the antidiarrheal potential of species of Maytenus genus, a phytochemical investigation followed by antib
An. Acad. Bras. Ciênc.. Publicado em: 2017-09
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6. Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation
ABSTRACT This study aimed to improve the water solubility of amiodarone hydrochloride (AMH) via inclusion complexes with β-cyclodextrin, methyl-β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin. Inclusion complexes were developed by physical mixture, coevaporation, spray-drying and freeze-drying. Solid state analysis was performed using X-ray powder diffr
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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7. Enantiomeric Separation of Sibutramine by Capillary Zone Electrophoresis
The chiral separation of sibutramine enantiomers was resolved succesfully by capillary zone electrophoresis using cyclodextrins (CDs) as chiral selectors. A complex screening of several different native and derivatized, neutral and ionized cyclodextrine derivatives was performed. The effects of buffer type, concentration and pH, cyclodextrin type and concent
J. Braz. Chem. Soc.. Publicado em: 2016-06
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8. A new alkalophilic isolate of Bacillus as a producer of cyclodextrin glycosyltransferase using cassava flour
Abstract Cyclodextrin glycosyltransferase (CGTase) catalyzes the conversion of starch into non-reducing cyclic sugars, cyclodextrins, which have several industrial applications. This study aimed to establish optimal culture conditions for β-CGTase production by Bacillus sp. SM-02, isolated from soil of cassava industries waste water lake. The optimization w
Braz. J. Microbiol.. Publicado em: 2016-03
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9. OBTENÇÃO E CARACTERIZAÇÃO DE MATERIAL HÍBRIDO ENTRE SÍLICA E CICLODEXTRINAS
The obtention of silica and cyclodextrin hybrid materials was accomplished by refluxing them in xylol using citric acid as a binding agent. The materials were characterized by infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, and elemental analysis. Evidence for the docking of cyclodextrins α and γ was subs
Quím. Nova. Publicado em: 2015-09
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10. Cromatografia gasosa quiral na resolução de enantiômeros envolvidos em flavours de frutas
This work addresses the use of chiral gas chromatography in resolving optically active stereoisomers and racemates found in fruit flavours. It presents the types of chiral selectors applied to terpene-derived metal coordination compounds, polysiloxane-linked α-amino acid and mixed chiral stationary phases, and focuses on derivatized cyclodextrins, the most
Quím. Nova. Publicado em: 2014
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11. Metalofármacos de dirutênio(II,III): síntese, caracterização e interações com biomoléculas e ciclodextrina / Diruthenium(II,III) metallodrugs: synthesis, characterization and interactions with biomolecules and cyclodextrin
Os compostos de coordenação de rutênio têm recebido grande atenção para tratamento do câncer. Em particular, estudos do grupo mostraram que um metalofármaco de dirutênio(II,III) com o fármaco anti-inflamatório não-esteróide ibuprofeno apresenta boa atividade para tumor cerebral maligno. Neste contexto, o presente trabalho teve como objetivo ampl
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/04/2012
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12. Eficácia anestésica da ropivacaína complexada com 2-hidroxipropil- beta -ciclodextrina em bloqueio dos nervos alveolar inferior e infraorbital e em infiltração subcutânea em ferida cirúrgica, em ratos / Anesthetic efficacy of ropivacaine with 2-hydroxypropyl-beta-cyclodextrin formulation in infraorbital and inferior alveolar nerve blocks and in surgical wound, in rats
Este estudo avaliou comparativamente a eficácia anestésica (tempo de latência, duração e sucesso da anestesia) da ropivacaína 0,5% complexada com 2-hidroxipropil-ß-ciclodextrina (sistema de liberação controlada de medicamentos), ropivacaína 0,5% sem aditivos e ropivacaína 0,5% com epinefrina 1:200.000, em três modelos experimentais em ratos: bloq
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/02/2012