Cyclin D1
Mostrando 13-24 de 692 artigos, teses e dissertações.
-
13. A combination of STI571 and BCR-ABL1 siRNA with overexpressed p15INK4B induced enhanced proliferation inhibition and apoptosis in chronic myeloid leukemia
p15INK4B, a cyclin-dependent kinase inhibitor, has been recognized as a tumor suppressor. Loss of or methylation of the p15INK4B gene in chronic myeloid leukemia (CML) cells enhances myeloid progenitor formation from common myeloid progenitors. Therefore, we examined the effects of overexpressed p15INK4B on proliferation and apoptosis of CML cells. Overexpre
Braz J Med Biol Res. Publicado em: 14/10/2014
-
14. Cyclin D1 expression in prostate carcinoma
The purpose of this study was to investigate the relationship between cyclin D1 expression and clinicopathological parameters in patients with prostate carcinoma. We assessed cyclin D1 expression by conventional immunohistochemistry in 85 patients who underwent radical prostatectomy for prostate carcinoma and 10 normal prostate tissue samples retrieved from
Braz J Med Biol Res. Publicado em: 2014-06
-
15. Effect of Wnt/β-catenin and NF-κB signaling pathways on mucus secretion with hypertonicity in 16HBE cells
This study aimed at identifying the molecular mechanisms and effects of hypertonicity on mucin5AC (MUC5AC) expression in airway epithelial cells for which immortalized human bronchial epithelial (16HBE) cells were cultured in 600 mOsm/L hypertonic medium for different times in vitro. Proteins of MUC5AC and β-catenin, Cyclin D1, NF-κB p65 were detected by e
Braz. arch. biol. technol.. Publicado em: 2013-08
-
16. Crude alkaloid extract of Rhazya stricta inhibits cell growth and sensitizes human lung cancer cells to cisplatin through induction of apoptosis
There is an urgent need to improve the clinical management of non-small cell lung cancer (NSCLC), one of the most frequent causes of cancer-related deaths in men and women worldwide. Rhazya stricta, an important medicinal plant used in traditional Oriental medicine, possesses anti-oxidant, anti-carcinogenic and free radical scavenging properties. This study
Genet. Mol. Biol.. Publicado em: 01/02/2013
-
17. Análise molecular dos genes HRPT2 e CICLINA D1 na displasia fibrosa, no fibroma ossificante e no osteossarcoma dos maxilares
Fibrous dysplasia (FD), ossifying fibroma (OF), and osteosarcoma (OS) are examples of bone-related lesions. Recent studies have already shown genetic alterations of the HRPT2 tumor suppressor gene in sporadic and syndromic OF. The present study first sought to raise the hypothesis of whether or not similar alterations would in fact represent one of the under
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/05/2012
-
18. Inhibition of cytohesin-1 by siRNA leads to reduced IGFR signaling in prostate cancer
To explore how cytohesin-1 (CYTH-1) small interfering RNA (siRNA) influences the insulin-like growth factor receptor (IGFR)-associated signal transduction in prostate cancer, we transfected human prostate cancer PC-3 cell lines with liposome-encapsulatedCYTH-1 siRNA in serum-free medium and exposed the cells to 100 nM IGF-1. The mRNA and protein levels of th
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-07
-
19. Curcumin, but not Prima-1, decreased tumor cell proliferation in the syngeneic murine orthotopic bladder tumor model
OBJECTIVE: Cigarette smoking is the main risk factor for bladder cancer development. Among the mediators of this effect of smoking is nuclear factor-kappa B. Curcumin suppresses cellular transformation by downregulating the activity of nuclear factor-kappa B. Prima-1 is a compound that induces apoptosis in human tumor cells, restoring the function of mutant
Clinics. Publicado em: 2011
-
20. AvaliaÃÃo clÃnica da corticoterapia intralesional em lesÃo cen-tral de cÃlulas gigantes dos maxilares : relevÃncia da expressÃo dos receptores de corticÃide e calcitonina, Cox-2, p16 e amplificaÃÃo da ciclina D1 / Clinical Assessment of Intralesional Corticotherapy for Central Giant Cells Lesion Of The Jaws â The Relevance Of Steroid Receptor Expression And Calcitonin, Cox-2, P16 and Amplification of Cyclin D1. Author: Ranato Luiz Maia Nogueira. Leader: Prof. Dr. Ronaldo Albuquerque Ribeiro.
A LesÃo Central de CÃlulas Gigantes dos maxilares (LCCG) Ã intra-Ãssea, nÃo tem predileÃÃo por sexo, classifica-se em agressivas e nÃo-agressivas, histologicamente consistem tecido fi-broso e celularizado fusiforme associado a cÃlulas gigantes multinucleadas (CGM), focos de hemorragia e neovascularizaÃÃo, tendo na cirurgia seu habitual tratamento.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/07/2010
-
21. Apoptosis induction by E2F decoy DNA of the prostate cancer cell line
To observe effect of E2F decoy DNA on proliferation and apoptosis of androgen-independent prostate cancer cell line PC-3M the binding specificity of the E2F decoy DNA to the PC-3M nuclear protein was detected by electrophoretic mobility shift assay (EMSA). E2F decoy DNA, ARE decoy DNA and Control decoy DNA were respectively transfected into PC-3M cells with
Brazilian Archives of Biology and Technology. Publicado em: 2010-04
-
22. A DNA enzyme targeting Egr-1 inhibits rat vascular smooth muscle cell proliferation by down-regulation of cyclin D1 and TGF-β1
We have demonstrated that a synthetic DNA enzyme targeting early growth response factor-1 (Egr-1) can inhibit neointimal hyperplasia following vascular injury. However, the detailed mechanism of this inhibition is not known. Thus, the objective of the present study was to further investigate potential inhibitory mechanisms. Catalytic DNA (ED5) and scrambled
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-01
-
23. Prognostic impact of p16, cyclin D1, CDK4, pRb, p53 and p21 expression in head, neck and trunk melanomas / Expressão imuno-histoquímica das proteínas p16, ciclina D1, CDK4, pRb, p53 e p21 em melanomas cutâneos de cabeça, pescoço e tronco e sua relação com prognóstico
O melanoma cutâneo é a neoplasia de pele de maior mortalidade. A imprevisibilidade de sua evolução é uma de suas características principais, o tratamento do tumor primário é, atualmente, de pouca morbidade e, na doença disseminada, as opções terapêuticas são pouco eficazes. É fundamental a pesquisa de marcadores tumorais que permitam a previsã
Publicado em: 2010
-
24. GTPases Rho e o potencial regenerativo da retina de mamíferos / Rho GTPases and the regenerative potential of the mammalian retina
Ciliary Body (CB) is a potential source of stem cells in the adult retina, but its activation is still unknown. Rho GTPases play a role in actin-based cytoskeleton reorganization, regulate signaling pathways and gene transcription, cell survival and cell proliferation. In this study we investigated the expression of Rho GTPases in CB cells and their role on
Publicado em: 2010