Cyclin B1
Mostrando 13-24 de 618 artigos, teses e dissertações.
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13. Growth inhibitory effect and Chk1-dependent signaling involved in G2/M arrest on human gastric cancer cells induced by diallyl disulfide
Diallyl disulfide (DADS) inhibits growth and induces cell cycle G2/M arrest in human gastric cancer MGC803 cells. In this study, 15 mg/L DADS exerted similar effects on growth and cell cycle arrest in human gastric cancer BGC823 cells. Due to the importance of cell cycle redistribution in DADS-mediated anti-carcinogenic effects, we investigated the role of c
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-03
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14. GTPases Rho e o potencial regenerativo da retina de mamíferos / Rho GTPases and the regenerative potential of the mammalian retina
Ciliary Body (CB) is a potential source of stem cells in the adult retina, but its activation is still unknown. Rho GTPases play a role in actin-based cytoskeleton reorganization, regulate signaling pathways and gene transcription, cell survival and cell proliferation. In this study we investigated the expression of Rho GTPases in CB cells and their role on
Publicado em: 2010
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15. Effects of curcumin in an orthotopic murine bladder tumor model
Cigarette smoking (CS) is the main risk factor for bladder cancer development. There are more than 100 carcinogens present in cigarette smoke. Among the potential mediators of CS-induced alterations is nuclear factor-kappa (NF-κB), which is responsible for the transcription of genes related to cell transformation, tumor promotion, angiogenesis, invasion and
International braz j urol. Publicado em: 2009-10
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16. Chagas disease, adipose tissue and the metabolic syndrome
Trypanosoma cruzi infection of the adipose tissue of mice triggers the local expression of inflammatory mediators and a reduction in the expression of the adipokine adiponectin. T. cruzi can be detected in adipose tissue by PCR 300 days post-infection. Infection of cultured adipocytes results in increased expression of cytokines and chemokines and a reductio
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-07
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17. Study of expression of proteins Metalotioneína, NFkB, Ciclina D1 and Cdk4 in cell lines derived from human squamous cell carcinoma / Estudo da expressão das proteínas metalotioneína, NFkB, ciclina D1 e Cdk4 em linhagens celulares derivadas de carcinoma epidermóide humano
O carcinoma epidermóide por se tratar de uma doença genética, apresenta dificuldades em relação ao seu tratamento. As vias de sinalização celular por controlarem os mecanismos responsáveis pela proliferação e sobrevivência da célula, são de extrema importância nos estudos da biologia do câncer e oncogênese. Aberrações cromossômicas que afe
Publicado em: 2008
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18. Primary bone lymphomas : comparison of the immunoexpression of apoptosis related proteins and adhesion molecules with nodal lymphomas and lymphomas metastatic to bone / Linfomas osseos primarios : estudo comparativo com linfomas nodais e linfomas osseos metastaticos quanto a imunoexpressão de proteinas relacionadas a apoptose, regulação do ciclo celular e adesão celular
The incidence of extranodal lymphomas is increasing in the last decades. Around 20 to 40% of B-cell non-Hodgkin lymphomas (NHL) arise outside the lymph nodes and may present distinct biological behavior, as compared to the corresponding nodal counterpart of similar histological grade. The heterogeneity of large B-cell lymphomas (LBCL) has been matter of vari
Publicado em: 2008
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19. Expressão da acido graxo sintase, ErbB-2, p27 E Skp2 na carinogenese bucal induzida por 1-oxido 4-nitroquinolina em camundongos e efeito antitumoral do Orlistat / Fatty Acid Sintase, ErbB-2, p27 E Skp2 expression in oral carcinogenesis induced by 4-nitroquinoline 1-oxide and antitumoral Orlistat effects
Squamous cell carcinoma of the oral cavity is one of the most common malignant epithelial neoplasms, and a better understanding of its molecular pathways could help the development of new treatment or preventive agents. Several proteins such as Fatty Acid Synthase (FAS), ErbB-2, p27 and Skp2 are involved in the tumorigenesis process. FAS has an enzyme with m
Publicado em: 2007
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20. Definição de alvos moleculares em diferenciação, morte e resistencia de celulas tumorais / Defenition of molecular targets indifferentiation, death and resisteance in cancer cells
Cancer therapy efficiency, under several aspects, even with the progress of pharmacotechnology, remains as a challenge for the medicine. According to this factor, new agents that act on specific target, present low side-effects and prevent cancer cells escaping from death induction, are extremely desirable. In this work, 3 aspects of antitumoral prop
Publicado em: 2007
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21. Detecção de HPV e avaliação do índice de proliferação celular entre carcinomas espinocelulares e carcinomas verrucosos de boca / HPV detection and evaluation of the index of cell proliferation between squamous cell carcinoma and verrucous carcinoma of the mouth
O carcinoma espinocelular (CEC) é a neoplasia maligna mais comum na cavidade bucal, e uma de suas variantes é o carcinoma verrucoso (CV), considerado de baixo grau de malignidade. O diagnóstico do CV é difícil, tanto do ponto de vista clínico quanto histopatológico e um efetivo diagnóstico é fundamental para estabelecer o tratamento e o prognóstico
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/11/2006
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22. Detecção de HPV e avaliação do índice de proliferação celular entre carcinomas espinocelulares e carcinomas verrucosos de boca / HPV detection and evaluation of the index of cell proliferation between squamous cell carcinoma and verrucous carcinoma of the mouth
Squamous cell carcinoma (SCC) is the most common malignant neoplasm of the bucal cavity, and one of its variants is verrucous carcinoma (VC), of low degree malignancy. The diagnosis of VC is difficult from the clinical as well as from the histopathological point of view, and an effective diagnosis is vital when deciding on the treatment and prognosis of this
Publicado em: 2006
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23. "Contribuição da imuno-histoquímica para a classificação dos linfomas de pequenas células B" / Contribution of immunohistochemistry to small B cell lymphomas classification
We evaluated the usefulness of a panel of antibodies comprising CD5, CD10, CD23, CD43, bcl-2 and cyclin D1 in the classification of 134 small B-cell lymphomas. CD10, positive in follicular lymphomas, CD23, positive in lymphocytic lymphoma/CLL and cyclin D1 expressed in mantle cell lymphoma were the ones that contributed the most in the differentiation of the
Publicado em: 2006
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24. PI3K signaling pathway activation and inactivation in head and neck squamous cell carcinoma: correlation with AET, B-catenin, cyclin D1 and PTEN expression / Ativação e bloqueio, da via de sinalização do PI3K, em células cultivadas de carcinoma epidermóide: correlação com a expressão das proteínas AKT, B-catenina, ciclina D1 e PTEN
O carcinoma epidermóide de cabeça e pescoço é responsável por 90% das neoplasias malignas, nesta região. Molecularmente, inúmeras vias de sinalização, ainda não muito bem compreendidas, são responsáveis pelo seu crescimento e invasão para tecidos vizinhos, além de metástases para órgãos distantes. Este trabalho destinou-se a avaliar o crosst
Publicado em: 2006