"Contribuição da imuno-histoquímica para a classificação dos linfomas de pequenas células B" / Contribution of immunohistochemistry to small B cell lymphomas classification

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

We evaluated the usefulness of a panel of antibodies comprising CD5, CD10, CD23, CD43, bcl-2 and cyclin D1 in the classification of 134 small B-cell lymphomas. CD10, positive in follicular lymphomas, CD23, positive in lymphocytic lymphoma/CLL and cyclin D1 expressed in mantle cell lymphoma were the ones that contributed the most in the differentiation of these lymphomas, confirming the diagnosis in 88.1% of the cases. The absence of nodular aspect and dendritic cells and the presence of proliferation centers differentiate the lymphocytic lymphoma/CLL from the other types. The expression of p53 protein and Ki-67 >20% was associated to a shorter survival, especially in mantle cell lymphoma

ASSUNTO(S)

imunohistoquímica prognóstico classification prognosis linfoma de pequenas células classificação lymphoma small-cell immunohistochemistry

ACESSO AO ARTIGO

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