Complement Classical Pathway
Mostrando 1-12 de 275 artigos, teses e dissertações.
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1. Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways
Background Activation of the complement system plays an important role in the regulation of immune and inflammatory reactions, and contributes to inflammatory responses triggered by envenomation provoked byBothrops snakes. The present study aimed to assess whether Bothrops jararacussuand Bothrops pirajai crude venoms and their isolated toxins, namely serine
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/09/2015
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2. Investigação de imunodeficiências primárias em pacientes com lúpus eritematoso sistêmico juvenil / Primary immunodeficiencies in juvenile systemic lupus erythematosus patients
Objetivos: Os objetivos deste estudo foram: avaliar a frequência de imunodeficiências primárias de anticorpos e Complemento em pacientes com lupus eritematoso sistêmico juvenil (LESJ); avaliar possíveis associações entre a presença de imunodeficiência primária (IDP) e dados demográficos, ocorrência de infecções, manifestações clínicas, ativi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/05/2011
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3. Avaliação do efeito de contraceptivos hormonais sobre o sistema complemento / Evaluation of the effect of hormonal contraceptives on the complement system
The occurrence of thrombosis is often associated with the presence of one or more risk factors, which may be genetic and/or acquired, such as hormonal changes that occur during pregnancy, hormone replacement therapy and the use of combined hormonal contraceptives (CHC). The inflammation in turn, is an important body\ s response to the aggression and involves
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/04/2011
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4. Modulação de eventos da imunidade humoral e celular por venenos brutos e componentes dos venenos de Bothrops jararacussu e Bothrops pirajai / Modulation of events of humoral and cellular immunity by crude venom and components of Bothrops jararacussu and Bothrops pirajai
Snakes of the genus Bothrops are responsible for 90% of snakebites in Brazil. Their venoms cause local effects in humans and animals, such as hemorrhage, edema, pain and necrosis, characteristic of an inflammatory response. The mechanism is not well defined. These effects are related to the combined action of proteases, substances that induce bleeding and ph
Publicado em: 2010
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5. Análise da detecção de C4d, linfócitos B e plasmócitos no processo de rejeição ao aloenxerto renal / Analysis of C4d, B lymphocytes and plasma cells detection in the renal allograft rejection
A rejeição ao aloenxerto mediada por mecanismos celulares ou humorais representa uma importante complicação no pós-transplante renal. Estudos anteriores demonstraram que o depósito de C4d peritubular é um marcador de rejeição mediada por anticorpos. A técnica padrão ouro para a pesquisa de C4d é a imunofluorescência em criostato. No entanto, o m
Publicado em: 2010
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6. Avaliação de mutações no gene do inibidor de C1 esterase em pacientes com angioedema hereditário / Mutations evaluation in C1 inhibitor gene in patients with hereditary angioedema
A ativação dos sistemas complemento e de contato resulta na formação de peptídeos vasoativos tais como a bradicinina e anafilatoxinas. O inibidor de C1-esterase (C1-INH) é o principal regulador desses dois sistemas e a deficiência desta proteína resulta no Angioedema Hereditário (AEH). Trata-se de uma doença rara, de herança autossômica dominante
Publicado em: 2009
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7. Avaliação da ação de rofa e de materiais particulados provenientes da queima de biomassa na resposta imune humoral de camundongos
The ambient pollution is one of the biggest problems of world-wide public health. Several epidemiological studies have demonstrated associations between high levels of particulate matter (MP) and increase of morbidity and mortality. Residual Oil Fly Ash (ROFA) and matter result from biomass burning have been widely used in experimental studies, with the aim
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/07/2007
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8. Trypanosoma cruzi e o Sistema Complemento: Mecanismos de ativação e o papel do gene CRIT (Complement C2 Receptor Inhibitor Trispanning) na resistência à lise em cepas de classe I e II / Trypanosoma cruzi E O SISTEMA COMPLEMENTO: MECANISMOS DE ATIVAÇÃO E O PAPEL DO GENE CRIT (COMPLEMENT C2 RECEPTOR INHIBITOR TRISPANNING) NA RESISTÊNCIA À LISE EM CEPAS DE CLASSE I E II / Trypanosoma cruzi e o Sistema Complemento: Mecanismos de ativação e o papel do gene CRIT (Complement C2 Receptor Inhibitor Trispanning) na resistência à lise em cepas de classe I e II / Trypanosoma cruzi E O SISTEMA COMPLEMENTO: MECANISMOS DE ATIVAÇÃO E O PAPEL DO GENE CRIT (COMPLEMENT C2 RECEPTOR INHIBITOR TRISPANNING) NA RESISTÊNCIA À LISE EM CEPAS DE CLASSE I E II
Trypanosoma cruzi, the agent of Chagas disease, infects 18 million people in Latin America. T. cruzi has an heteroxicenous life cycle infecting vertebrates and invertebrate hosts. Two classes of T. cruzi have been proposed based on molecular markers, the class I with a sylvatic life cycle infecting mostly marsupials, while class II parasites have a domestic
Publicado em: 2006
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9. Caracterização molecular da deficiencia de proteina S
Human protein S is a plasmatic vitamin-K dependent glicoprotein that acts as a non-enzimatic cofactor of activated protein C in the protein C anticoagulant pathway. In addition to this protein S has an independent role that activated protein C, which is to inactivate factors Va and Xa. The plasmatic concentration of protein S is regulated by a C4b binding pr
Publicado em: 1998
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10. Interaction of complex polysaccharides with the complement system: effect of calcium depletion on terminal component consumption.
Complex polysaccharides and lipopolysaccharides can activate the terminal components of complement by either the classical (antibody, C1, C4, and C2) or alternative complement pathways, but the relative importance of either pathway for terminal component consumption in normal serum is poorly understood. Since classical complement pathway function requires bo
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11. Role of the Classical Pathway of Complement Activation in Experimentally Induced Polymicrobial Peritonitis
The complement system and the natural antibody repertoire provide a critical first-line defense against infection. The binding of natural antibodies to microbial surfaces opsonizes invading microorganisms and activates complement via the classical pathway. Both defense systems cooperate within the innate immune response. We studied the role of the complement
American Society for Microbiology.
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12. The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice
The complement system is an important component of the innate immune response to bacterial pathogens, including Streptococcus pneumoniae. The classical complement pathway is activated by antibody–antigen complexes on the bacterial surface and has been considered predominately to be an effector of the adaptive immune response, whereas the alternative and ma
National Academy of Sciences.