Collagen Type V Immunization
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Anti-collagen type v: a marker of early systemic sclerosis?
Abstract Objective: To evaluate the frequency of anti-collagen type V in humans with early systemic sclerosis (SSc) compared to defined SSc patients and healthy controls, since collagen type V was shown to be overexpressed in early SSc patients’ skin and there is no data concerning the presence of this antibody in early stages of human SSc. Experimental s
Adv. rheumatol.. Publicado em: 29/07/2019
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2. Histomorphometric analysis of cutaneous remodeling in the early stage of the scleroderma model
INTRODUCTION/OBJECTIVES: Systemic sclerosis, or scleroderma, is a rheumatic disease characterized by autoimmunity, vasculopathy, and fibrosis of the skin and several internal organs. In the present study, our aim was to assess the skin alterations in animals with scleroderma during the first stages of disease induction. METHODS: To induce scleroderma, female
Clinics. Publicado em: 2009-06
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3. Collagen V- induced nasal tolerance in scleroderma experimental model / Indução de tolerância nasal com colágeno tipo V em modelo experimental de esclerodermia
Objective: Our aim was to verify the skin remodeling and antibody production in experimental model of scleroderma in rabbits, after induction of tolerance by daily nasal administration of human type V collagen (Col V). Methods: Female New Zealand rabbits (N=12) were immunized with 1mg/ml of Col V in complete Freunds adjuvant, followed by more two boosters in
Publicado em: 2007
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4. Morphometric study of immune cellular and pre-acinar axis remodeling by type V collagen induction on bronchiolite obliterans model / Estudo morfométrico da imunidade celular e remodelamento no eixo pré-acinar na indução do colágeno tipo V em um modelo de bronquiolite obliterante
A minority of patients with remodeling process of lungs following bronquiolite obliterante (BO) responds to corticosteroids. So, we sought to validate the importance of type V collagen (tVc) tolerance from immunization as option in BO model treatment. Througt of morphometric analyses, we have mensured for the dimensions, the collagen and cell infiltration de
Publicado em: 2007
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5. Morphological and biochemical analysis of the synovia of rabbits immunized with type V collagen / "Análise morfológica e bioquímica da sinóvia de coelhos imunizados com colágeno do tipo V"
We described an original model of experimental synovitis in rabbits immunized with collagen V with scant cellular infiltration, intense matrix remodeling and vasculitis. Morphological and biochemical analysis were realized in New Zealand female rabbits (N=20) immunization with type V collagen, compared with control rabbits. It was observed increase of collag
Publicado em: 2005
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6. Humoral immune response characterization of the type V collagen induced scleroderma experimental model / Caracterização da resposta imune em modelo experimental de esclerodermia induzida por colágeno tipo V
Experimental models for human diseases are of utmost importance, since they allow the study of their pathogenesis and therapeutic approach. In this group we can include the experimental model of collagen V-induced scleroderma, in rabbits, with histological alterations (skin, lung and kidney) similar to those observed in humans. Auto-immune diseases have an u
Publicado em: 2005
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7. Immunization with T cell receptor V beta chain peptides deletes pathogenic T cells and prevents the induction of collagen-induced arthritis in mice.
Collagen-induced arthritis (CIA) in susceptible strains of mice is an animal model of T cell-mediated inflammatory polyarthritis. Analysis of T cell receptor (TCR) V beta gene usage in cells isolated from arthritic joints of BUB/BnJ (BUB) mice (H-2q, TCR V beta a) showed that TCR V beta chain gene usage was limited to TCR V beta 3 and V beta 10 gene families
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8. Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis.
Immunization of mice with rat type II collagen (CII), a cartilage-specific protein, leads to development of collagen-induced arthritis (CIA), a model for rheumatoid arthritis. To define the interaction between the immune system and cartilage, we produced two sets of transgenic mice. In the first we point mutated the mouse CII gene to express an earlier defin