Cochlear Activity
Mostrando 1-12 de 27 artigos, teses e dissertações.
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1. The Effects of Experimental Intratympanic Steroid Administration on Organ of Corti Type 1 Spiral Ganglion
Abstract Introduction It is unclear how effective is the intratympanic (IT) steroid treatment on organ of Corti type 1 spiral ganglion, its optimal dosage and frequency of administration. The effect of dexamethasone on cochlear functions in individuals with a normal hearing ability is also unknown. Objective The aim of this study was to evaluate, at the
Int. Arch. Otorhinolaryngol.. Publicado em: 2018-06
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2. Síntese e relação estrutura-toxicidade de derivados aminoglicosídeos como potenciais protótipos na busca de um fármaco seguro para o tratamento da Doença de Ménière / Synthesis and structure-toxicity relationship of aminoglycosides derivatives as a lead in the search for a selective drug for the treatment of Méniere disease.
Os aminoglicosídeos são antibióticos utilizados para o tratamento de muitas infecções bacterianas graves. A maioria é produzida por microorganismos (gêneros Streptomyces e Actinomyces), mas a semi-síntese resultam na descoberta de notáveis aminoglicosídeos. Apesar de seu mecanismo de ação seletivo, os aminoglicosídeos são extremamente tóxicos.
Publicado em: 2010
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3. The maturational process of the auditory system in the first year of life characterized by brainstem auditory evoked potentials
The study of brainstem auditory evoked potentials (BAEP) allows obtaining the electrophysiological activity generated in the cochlear nerve to the inferior colliculus. In the first months of life, a period of greater neuronal plasticity, important changes are observed in the absolute latency and inter-peak intervals of BAEP, which occur up to the completion
Journal of Applied Oral Science. Publicado em: 2009
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4. Estudo da prevalência da perda auditiva neurossensorial como complicação da Doença de Kawasaki
Introduction: Kawasaki Disease (KD) is an acute systemic vasculitis of unknown etiology whose main complication is the coronary arteritis. Cases of sensorineural hearing loss have also been described as complication of this disorder. Objective: To evaluate in patients with KD: (a) prevalence of sensorineural hearing loss (temporary or permanent), and to dete
Publicado em: 2008
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5. Type 2 iodothyronine deiodinase expression in the cochlea before the onset of hearing
Thyroid hormone signaling during a postnatal period in the mouse is essential for cochlear development and the subsequent onset of hearing. To study the control of this temporal dependency, we investigated the role of iodothyronine deiodinases, which in target tissues convert the prohormone thyroxine into triiodothyronine (T3), the active ligand for the thyr
The National Academy of Sciences.
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6. The effects of intracochlear cyanide and tetrodotoxin on the properties of single cochlear nerve fibres in the cat.
1. Tuning properties and spontaneous discharge rate of single cochlear fibres in the anaesthetized cat were determined under conditions where millimolar concentrations of KCN were instilled into the scala tympani. 2. Short-term effects on the tuning properties were obtained, in which the threshold of the low threshold sharply tuned tip segment of the frequen
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7. Evidence for vestibular regulation of autonomic functions in a mouse genetic model
Physiological responses to changes in the gravitational field and body position, as well as symptoms of patients with anxiety-related disorders, have indicated an interrelationship between vestibular function and stress responses. However, the relative significance of cochlear and vestibular information in autonomic regulation remains unresolved because of t
National Academy of Sciences.
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8. Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase
The later stages of cochlear differentiation and the developmental onset of hearing require thyroid hormone. Although thyroid hormone receptors (TRs) are a prerequisite for this process, it is likely that other factors modify TR activity during cochlear development. The mouse cochlea expresses type 2 deiodinase (D2), an enzyme that converts thyroxine, the ma
National Academy of Sciences.
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9. Electrical Properties and Functional Expression of Ionic Channels in Cochlear Inner Hair Cells of Mice Lacking the α10 Nicotinic Cholinergic Receptor Subunit
Cochlear inner hair cells (IHCs) release neurotransmitter onto afferent auditory nerve fibers in response to sound stimulation. During early development, synaptic transmission is triggered by spontaneous Ca2+ spikes which are modulated by an efferent cholinergic innervation to IHCs. This synapse is inhibitory and mediated by the α9α10 nicotinic cholinergic
Springer-Verlag.
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10. Active control of waves in a cochlear model with subpartitions.
Multiscale asymptotic methods developed previously to study macromechanical wave propagation in cochlear models are generalized here to include active control of a cochlear partition having three subpartitions, the basilar membrane, the reticular lamina, and the tectorial membrane. Activation of outer hair cells by stereocilia displacement and/or by lateral
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11. Purification of a carbonic anhydrase from the inner ear of the guinea pig.
A soluble carbonic anhydrase (carbonate hydro-lyase, EC 4.2.1.1) has been purified to homogeneity from the membranous lateral wall (stria vascularis, spiral ligament, spiral prominence, and outer sulcus) of the guinea-pig inner ear. About 1% of the protein of the membranous lateral wall is carbonic anhydrase. The specific activity of the enzyme in homogenate
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12. The location of the cochlear amplifier: Spatial representation of a single tone on the guinea pig basilar membrane
Acoustic stimulation vibrates the cochlear basilar membrane, initiating a wave of displacement that travels toward the apex and reaches a peak over a restricted region according to the stimulus frequency. In this characteristic frequency region, a tone at the characteristic frequency maximally excites the sensory hair cells of the organ of Corti, which trans
The National Academy of Sciences of the USA.