Clotrimazole
Mostrando 1-12 de 134 artigos, teses e dissertações.
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1. Eficácia do clotrimazol tópico versus tolnaftato tópico no tratamento da otomicose: um ensaio clínico controlado randomizado
Resumo Introdução: Otomicose, uma infecção fúngica do canal auditivo externo, é prevalente em climas quentes e úmidos. No entanto, a literatura não apresenta evidências suficientes sobre os diferentes tratamentos antifúngicos tópicos. O tolnaftato é um antifúngico tópico descrito como eficaz no tratamento da otomicose; entretanto, sua eficáci
Braz. j. otorhinolaryngol.. Publicado em: 2020-06
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2. Possible mechanisms involved in the vasorelaxant effect produced by clobenzorex in aortic segments of rats
Clobenzorex is a metabolic precursor of amphetamine indicated for the treatment of obesity. Amphetamines have been involved with cardiovascular side effects such as hypertension and pulmonary arterial hypertension. The aim of the present study was to investigate whether the direct application of 10–9–10–5 M clobenzorex on isolated phenylephrine-precont
Braz J Med Biol Res. Publicado em: 07/08/2017
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3. Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application
ABSTRACT The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equatio
An. Acad. Bras. Ciênc.. Publicado em: 01/12/2016
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4. Deficiency of sex hormones does not affect 17-ß-estradiol-induced coronary vasodilation in the isolated rat heart
The relaxation of coronary arteries by estrogens in the coronary vascular beds of naive and hypertensive rats has been well described. However, little is known about this action in gonadectomized rats. We investigated the effect of 17-ß-estradiol (E2) in coronary arteries from gonadectomized rats, as well as the contributions of endothelium-derived factors
Braz J Med Biol Res. Publicado em: 12/04/2016
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5. Mechanisms involved in the vasorelaxant effects produced by the acute application of amfepramone
in vitro to rat aortic ringsAmfepramone (diethylpropion) is an appetite-suppressant drug used for the treatment of overweight and obesity. It has been suggested that the systemic and central activity of amfepramone produces cardiovascular effects such as transient ischemic attacks and primary pulmonary hypertension. However, it is not known whether amfepramone produces immediate vas
Braz J Med Biol Res. Publicado em: 27/03/2015
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6. In vitro and in vivo antifungal activity, liver profile test, and mutagenic activity of five plants used in traditional Mexican medicine
Berberis hartwegii Benth., Berberidaceae, Hamelia patens Jacq., Rubiaceae, Dendropanax arboreus (L.) Decne & Planch., Araliaceae, Erythrina herbacea L., Fabaceae, and Zanthoxylum caribaeum Lam., Rutaceae, acetone extracts were selected on the basis of their use in traditional Mexican medicine to treat scabies or skin diseases. Anti-dermatophyte activity in
Rev. bras. farmacogn.. Publicado em: 2015-02
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7. Susceptibility variation of Malassezia pachydermatis to antifungal agents according to isolate source
Malassezia pachydermatisis associated with dermatomycoses and otomycosis in dogs and cats. This study compared the susceptibility of M. pachydermatis isolates from sick (G1) and healthy (G2) animals to azole and polyene antifungals using the M27-A3 protocol. Isolates from G1 animals were less sensitive to amphotericin B, nystatin, fluconazole, clotrimazole a
Braz. J. Microbiol.. Publicado em: 26/03/2013
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8. Modulation of the oxidative stress in malaria infection by clotrimazole
O antifúngico clotrimazol (CTZ) tem demonstrado notável atividade contra Plasmodium falciparum. A degradação da hemoglobina por Plasmodium para a obtenção dos aminoácidos necessários à síntese protéica induz estresse oxidativo em eritrócitos devido à liberação de hemos oxidantes. Estes eventos representam alvos bioquímicos para a produção d
Braz. J. Pharm. Sci.. Publicado em: 2012-09
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9. SPE-HPLC method for determination of ketoconazole and clotrimazole residues in cow's milk
Um método simples confirmatório para determinação em HPLC-UV de resíduos de cetoconazol e clotrimazol em leite de vaca, após extração da fase sólida (SPE), é relatado neste artigo. Foram removidos das amostras proteínas e lipídeos por tratamento com acetonitrila e conseqüente extração em n-hexano. Os extratos foram posteriormente limpos e conc
Journal of the Brazilian Chemical Society. Publicado em: 2011-09
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10. Disturbance in hemoglobin metabolism and in vivo antimalarial activity of azole antimycotics
Plasmodium parasites degrade host hemoglobin to obtain free amino acids, essential for protein synthesis. During this event, free toxic heme moieties crystallize spontaneously to produce a non-toxic pigment called hemozoin or ß-hematin. In this context, a group of azole antimycotics, clotrimazole (CTZ), ketoconazole (KTZ) and fluconazole (FCZ), were investi
Revista do Instituto de Medicina Tropical de São Paulo. Publicado em: 2011-02
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11. Effect of brassinosteroid on growth, biochemical composition and transport of amino acids in plants-of Cajanus cajan (L.) Millsp, cultivated under salt stress / Efeito de brassinosteroide no cerescimento, parametros bioquimicos e transporte de aminoacidos em plantas de Cajanus cajan (L.) Millsp, submetidas a estresse salino
Plantas de Cajanus cajan receberam aplicações de brassinosteróide ou de clotrimazol (inibidor de síntese de brassinosteróides) e foram submetidas à salinidade. O objetivo deste trabalho foi verificar o efeito de duas concentrações de brassinosteróide (1 x 10-7 e 0,5 x 10-9 M) e uma de clotrimazol (1 x 10-4 M), no crescimento, composição bioquímic
Publicado em: 2007
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12. Bone marrow stroma modulates the expression of several drug resistance/sensitivity genes in pediatric acute limphoblastic leukemia / O estroma da medula ossea e a sua influencia na expressão de genes de resistencia e sensibilidade a quimioterapicos na leucemia linfoide aguda (LLA) pediatrica
The intrinsic or acquired chemotherapy resistance composites one of the most important causes of failures in the treatment of pediatric ALL. The ALL and bone marrow microenvironment nteraction contributes for the proliferation and resistance to the chemotherapy regimen of leukemic cells probably through a great variety of cellular mechanisms, including incre
Publicado em: 2007