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1. Influência dos polimofismos de nucleotídeo único (SNPs) da APOBEC3G na dinâmica populacional da infecção pelo HIV-1 / Influence of single nucleotide polymorphisms of APOBEC3G in the population dynamic in the HIV-1 infection
APOBEC3G (A3G) has been described as a cellular factor that inhibits replication of HIV-1. During reverse transcription, A3G promotes deamination of cytidine to uracil in the minus strand viral DNA, inducing hypermutation of guanines to adenines in plus strand DNA. The HIV-1 counters this effect by the activity of the viral protein Vif, which counteracts A3G
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/04/2011