Ciclooxygenase 2
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Ciclooxigenase-2 modula in vivo a expressão de marcadores da osteoclastogênese e genes envolvidos no metabolismo ósseo em resposta ao lipopolissacarídeo bacteriano / Ciclooxygenase-2 modulates in vivo the expression of osteoclastiogenesis makers and genes involved in bone metabolism in response to bacterial lipopolysaccharide
During an inflammatory response, several mediators are locally released in order to stimulate cellular and humoral immune response. Through the action of cyclooxygenase and lipoxygenase enzymes structural changes occur in the arachidonic acid chain leading to synthesis of prostaglandins or leukotrienes and lipoxins, respectively. Such mediators are responsib
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/06/2012
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2. Study of angiogenesis and temporal expression of VEGF and its receptors VEGFR-1/Flt-1 VEGFR-2/Flk-1 during the normal alveolar bone repair and with therapeutic use of a nonsteroidal anti-inflammatory selective for COX-2 in rats / Estudo da angiogênese e da expressão temporal do VEGF e dos seus receptores VEGFR-1/Flt-1 e VEGFR-2/Flk-1 durante o reparo ósseo alveolar normal e com uso terapêutico de um antiinflamatório não esteroidal seletivo para COX-2 em ratos
Objetivo: Avaliar o efeito do Meloxicam sobre a expressão do VEGF e de seus receptores durante o reparo alveolar pós-exodontia em ratos. Material e Método: Foi realizada a exodontia do incisivo superior direito em 180 ratos Wistar, machos, com 60 dias de idade, subdivididos em dois grupos: 1) Grupo controle (n=90): os animais receberam injeção intraperi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/12/2011
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3. Leucoplasia oral: tratamento cirúrgico com laser de CO2 e de diodo e análise por imuno-histoquímica da expressão de proteínas relacionadas à carcinogênese (p53, COX-2 e EGFR) / Oral leukoplakia: surgical treatment with CO2 and diode lasers and analysis of the expression of proteins related to carcinogenesis (p53, COX-2 e EGFR) by immunohistochemistry
Oral leukoplakia (OL) is a potentially malignant lesion, defined as a white patch that cannot be characterized as any other disease of the oral mucosa. In general, OL should be treated; however no treatment available has been able to prevent malignant transformation. The aim of this study was to evaluate the efficacy of surgical treatment with CO2 and diode
Publicado em: 2010
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4. Efeito dos extratos de Harpagohytum procumbens (garra-do-diabo) e suas frações na atividade da COX-1 e COX-2 e na produção de NO em sangue total / Effects of harpagophytum procumbens (devils claw) extracts and its fractions on Cox-1 and Cox-2 activity and nitric oxide production in whole blood.
OBJECTIVE: The present study evaluated the effect of H. procumbens extracts and its fractions on COX-1 and COX-2 activity and NO production in whole blood assays of volunteers and OA patients. METHODS: The COX-1 and COX-2 activity was quantified as platelet TXB2 production in blood clotting and as PGE2 production in heparinized LPS-stimulated whole blood, re
Publicado em: 2008
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5. Analise histoquimica, ultra-estrutural e morfometrica do efeito de drogas anti-inflamatorias não esteroides (naproxeno e indometacina) sob a regeneração da nadadeira caudal de teleosteo, Cyprinus carpio (carpa) / Histochemical, ultra-structural and morphometric analysis of the effect of nonsteroidal anti-inflammatory drugs (naproxen and indomethacin) under the tail fin regeneration of teleostm Cyprinus carpio (carp)
The fins of teleosts, when partially amputated, they pass for a quick regenerative process called epimorphic regeneration, characterized by the formation of a mass of undifferentiated cells, by the differentiation of these cells, by the synthesis and the deposition of the extracellular matrix and morphological restoration. The regeneration of the fin is extr
Publicado em: 2008
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6. Evaluation of the anti-inflammatory effects of the interleukin-1 receptor antagonist protein in equine synovial fluid using flow cytometric techniques / Avaliação dos efeitos antiinflamatórios da proteína antagonista de receptor de interleucina - 1 (IRAP) por citometria de fluxo em líquido sinovial de eqüino
Joint disease in horses, specifically osteoarthritis, is one of the most prevalent and debilitating illnesses affecting equine industry and for this reason continued research and improvements in therapeutics are needed. Osteoarthritis is a degenerative disease that can be triggered by a number of factors and where ultimately all articular tissues are affecte
Publicado em: 2007
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7. EFEITO CLÍNICO DO USO DE PARECOXIB EM SINOVITE INDUZIDA EM PÔNEIS / EFFECT OF PARECOXIB IN INDUCED SYNOVITIS IN HORSES
Acute synovitis and capsulitis are common articular problems and can contribute to the development of a degenerative process due to the release of enzymes and inflammatory mediators. The indicated treatment for synovitis and capsulitis is based on anti-inflammatory drugs. An experimental synovitis model was used in ponies to evaluate the effect of parecoxib,
Publicado em: 2006
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8. Estudo clinico do alho fresco em voluntarios sadios : avaliação da agregação plaquetaria in vitro e in vivo e comportamento da pressão arterial atraves da MAPA in vivo
Objective: This thesis has as objectives: to evaluate the platelet aggregation and the behavior of blood pressure in three moments (control; garlic single dose (3,5 g) and garlic daily dose (3,5 g) twice a day for 4 days) in healthy volunteers; To analyze the in vitro platelet aggregation answer adding garlic extract diluted in PRP and the last to correlate
Publicado em: 2004