Chromosome Alterations
Mostrando 13-24 de 298 artigos, teses e dissertações.
-
13. What influences Hb fetal production in adulthood?
Human hemoglobin genes are located in α and β globin gene clusters in chromosomes 16 and 11, respectively. Different types of hemoglobin are synthesized according to the stage of development with fetal hemoglobin (α2γ2) (Hb F) being the main hemoglobin in the fetal period. After birth, there is a reduction (to about 1%) in Hb F levels and adult hemoglobi
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011-06
-
14. Chromosomal and molecular abnormalities in a group of Brazilian infertile men with severe oligozoospermia or non-obstructive azoospermia attending an infertility service
PURPOSE: To determine the frequency of genetic alterations in a population of Brazilian infertile men with severe oligozoospermia or non-obstructive azoospermia. MATERIALS AND METHODS: Retrospective study of a group of 143 infertile men with severe oligozoospermia or non-obstructive azoospermia from the Andrology Outpatient Clinic of the Human Reproduction S
International braz j urol. Publicado em: 2011-04
-
15. Characterization of alpha thalassemic genotypes by multiplex ligation-dependent probe amplification in the Brazilian population
Alpha-thalassemia is the most common inherited disorder of hemoglobin synthesis. Genomic deletions involving the alpha-globin gene cluster on chromosome 16p13.3 are the most frequent molecular causes of the disease. Although common deletions can be detected by a single multiplex gap-PCR, the rare and novel deletions depend on more laborious techniques for th
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-01
-
16. Genomic alterations detected by comparative genomic hybridization in ovarian endometriomas
Endometriosis is a complex and multifactorial disease. Chromosomal imbalance screening in endometriotic tissue can be used to detect hot-spot regions in the search for a possible genetic marker for endometriosis. The objective of the present study was to detect chromosomal imbalances by comparative genomic hybridization (CGH) in ectopic tissue samples from o
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-08
-
17. Cytogenetic characterization and evaluation of c-MYC gene amplification in PG100, a new Brazilian gastric cancer cell line
Gastric cancer is the fourth most frequent type of cancer and the second cause of cancer mortality worldwide. The genetic alterations described so far for gastric carcinomas include amplifications and mutations of the c-ERBB2, KRAS, MET, TP53, and c-MYC genes. Chromosomal instability described for gastric cancer includes gains and losses of whole chromosomes
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-08
-
18. Cytological characterization of an Aspergillus nidulans mutant from a strain with chromosomic duplication
A development mutant, named V103, was obtained spontaneously from the A strain of A. nidulans. The A strain contains a duplicated segment of chromosome I that has undergone translocation to chromosome II (I → II). It is mitotically unstable and generates phenotypically deteriorated types, some with enhanced stability. The deteriorated variants of A. nidula
Brazilian Journal of Microbiology. Publicado em: 2010-03
-
19. Biomonitoramento genÃtico de indivÃduos expostos ocupacionalmente a pesticidas no povoado Vila Bessa, municÃpio de ConceiÃÃo do JacuÃpe, Bahia / Genetic biomonitoring of individuals occupationally exposed to pesticides in the village Vila Bassa, municipality of ConceiÃÃo do JacuÃpe, Bahia
The high consumption of pesticides in Brazil and all over the world have lead researches to relate this exposition to possible genetic and health damages in rural workers. Studies reveal that cancer is considered a genetic disease, once it results of the mutation accrual in genes involved with control of proliferation and cellular differentiation or mutation
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/11/2009
-
20. Hibridação genômica comparativa (CGH) em neoplasias gástricas de indivíduos do estado do Pará. / Comparative Genomic hybridization (CGH) in individuals from Northern Brazil with gastric adenocarcinoma.
Gastric adenocarcinoma is a serious public health concern, especially in the Northern Brazil. Gastric cancer can be subdivided into diffuse-type and intestinal-type. Genetic imbalances in diffuse-type gastric cancer remain largely unknown. In the present study, we analyzed 24 advanced diffuse-type gastric cancer samples from Northern Brazil subjects using hi
Publicado em: 2009
-
21. Preferential induction of MLL (Mixed Lineage Leukemia) rearrangements in human lymphocyte cultures treated with etoposide
Topoisomerase II inhibitors are effective chemotherapeutic agents in the treatment of cancer, in spite of being associated with the development of secondary leukemia. Our purpose was to determine the effects of etoposide on different genomic regions, aiming at discovering whether there are preferential sites which can be targeted by this drug in peripheral l
Genetics and Molecular Biology. Publicado em: 2009
-
22. Influência da distrofia muscular do Golden Retriever (GRMD) na viabilidade espermática e nas características morfológicas do aparelho reprodutivo masculino / Influence of Golden Retriever muscular dystrophy (GRMD) on sperm viability and on morphologic characteristics of the male reproductive tract
Muscular dystrophies constitute a group of diseases characterized by progressive and irreversible muscle degeneration. Duchenne´s Muscular Dystrophy (DMD) is a lethal myopathy caused by dystrophin deficiency, a muscular cell cytoskeleton protein. The dystrophin gene have recessive characteristic and is located in the p21 portion of the X chromosome. Advance
Publicado em: 2009
-
23. Compared cytogenetic analysis in mast cell tumors: a special focus on Boxer breed / Análise citogenética comparada em mastocitomas: enfoque especial na raça Boxer
Atualmente muitas são as técnicas utilizadas na área de citogenética para que os desequilíbrios genéticos potencialmente hereditários sejam identificados ou evitados. Algumas das técnicas são utilizadas apenas para o diagnóstico de enfermidades em humanos, mas seria importante que fossem aplicadas também aos animais domésticos, com a finalidade d
Publicado em: 2009
-
24. Assessing the Molecular and Genetic Aspects of Squamous Cell Carcinoma of the Larynx / Avaliação Genético-Molecular do Carcinoma das Células Escamosas da Laringe
The larynx is a structure of the upper aerodigestive tract responsible for the production of sounds as well as protecting the lower airways and helping during the normal act of swallowing. Any pathology which affects the larynx can impose several challenges that disrupt its normal physiological function, and consequently and directly resulting in reduction o
Publicado em: 2009