Hibridação genômica comparativa (CGH) em neoplasias gástricas de indivíduos do estado do Pará. / Comparative Genomic hybridization (CGH) in individuals from Northern Brazil with gastric adenocarcinoma.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Gastric adenocarcinoma is a serious public health concern, especially in the Northern Brazil. Gastric cancer can be subdivided into diffuse-type and intestinal-type. Genetic imbalances in diffuse-type gastric cancer remain largely unknown. In the present study, we analyzed 24 advanced diffuse-type gastric cancer samples from Northern Brazil subjects using high-resolution comparative genomic hybridization. We found chromosomal alterations in 75% of samples. In aneusomy cancers, the mean genomic copy number alteration was 6.4. Losses of chromosome regions exceeded gains. The most frequent losses were located at chromosome regions 11q and 18q (5 samples for each region), 1pq, 3q, 4q, 5q, 13q and 14q (4 samples), followed by 2pq, 7p, 9pq, 11p, and 16p (3 samples). Our results confirm that gastric cancer has a complex pattern of chromosomal alterations which can be due to general chromosomal instability related to the advanced stage of gastric carcinogenesis. Loss of 11q and 18q were the most frequent chromosomal change in diffuse-type gastric adenocarcinoma in individuals from Northern Brazil. Frequent loss of 11q chromosome region in this gastric cancer may be peculiar among this population.

ASSUNTO(S)

delecao cromossomica. morfologia neoplasias gastricas

ACESSO AO ARTIGO

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