Chromosomal Aberrations
Mostrando 25-36 de 214 artigos, teses e dissertações.
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25. Análise cromossômica dos linfócitos do sangue periférico e dos polimorfismos do gene de reparo do DNA XRCC1 em indivíduos com anemia falciforme.
Sickle cell disease is an inherited disorder caused by a single nucleotide substitution in the β-globin gene. The clinical heterogeneity observed in sickle cell disease patients has been attributed to environmental and genetic factors. Patients with sickle cell disease are subjected to increased oxidative stress, particularly during vaso-occlusive crise
Publicado em: 2007
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26. Atypical chromosome abnormalities in acute myeloid leukemia type M4
This study reports an adult AML-M4 patient with atypical chromosomal aberrations present in all dividing bone marrow cell at diagnosis: t(1;8)(p32.1;q24.2), der(9)t(9;10)(q22;?), and ins(19;9)(p13.3;q22q34) that may have originated transcripts with leukemogenic potential.
Genetics and Molecular Biology. Publicado em: 2007
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27. Cytogenetics investigation on orofacial cleft individuals and screening of informative cases for further studies / Investigação citogenetica em individuos com fendas orofaciais e triagem dos casos informativos para estudos especificos
Cleft lip with or without cleft palate (CL/P) occurs in approximately 1/500 to 1/1000 newborns and cleft palate (CP), etiologically distinct, in approximately 0,4/1000 newborns. They have a complex etiology, and the great majority of clefts appear to be isolated anomalies, in which have been observed a very important genetic component. However, in a signific
Publicado em: 2007
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28. Genotoxicity and mutagenicity of water contaminated with tannery effluents, as evaluated by the micronucleus test and comet assay using the fish Oreochromis niloticus and chromosome aberrations in onion root-tips
Cytotoxicity of metals is important because some metals are potential mutagens able to induce tumors in humans and experimental animals. Chromium can damage DNA in several ways, including DNA double strand breaks (DSBs) which generate chromosomal aberrations, micronucleus formation, sister chromatid exchange, formation of DNA adducts and alterations in DNA r
Genetics and Molecular Biology. Publicado em: 2006
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29. CARACTERIZAÇÃO DE PACIENTES COM INDICAÇÃO CLINÍCA PARA CARIÓTIPO EM UM HOSPITAL DE REABILITAÇÃO. / CHARACTERIZATION OF PATIENTS WITH CLINICAL INDICATION KARYOTYPE IN A HOSPITAL FOR REHABILITATION.
Neste estudo são apresentados os resultados da avaliação citogenética de 694 pacientes, com suspeita de serem portadores de anomalia cromossômica, atendidos na Rede Sarah de Hospitais de Reabilitação - Unidade São Luís, no período de dezembro de 1996 a janeiro de 2005.
Publicado em: 2006
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30. No clastogenic activity of Caesalpinia ferrea Mart. (Leguminosae) extract on bone marrow cells of Wistar rats
Extracts of the fruits of Caesalpinia ferrea Mart. (Leguminosae) are widely consumed in folkloric medicine in Brazil and several other countries without any genetic toxicity evaluation. In this study we investigated, the clastogenic and cytotoxic potential of the crude aqueous extract of the fruits of C. ferrea in Wistar rat bone marrow cells using the micro
Genetics and Molecular Biology. Publicado em: 2006
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31. In vivo cytogenetic effects of multiple doses of dietary vegetable oils
Polyphenols are potent antioxidants that are particularly abundant in the Mediterranean diet, with olive oil being the main fat source. A number of investigations have reported that phenolic compounds found in dietary oils are antioxidants and could provide protective effects by inhibiting DNA oxidative damage. However, few studies have been published on the
Genetics and Molecular Biology. Publicado em: 2006
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32. Individual sensitivity to cytogenetic effects of benzo[alpha]pyrene in cultured human lymphocytes: influence of glutathione S-transferase M1 genotype
Sister chromatid exchange (SCE) and chromosome aberrations (CA) in peripheral lymphocytes has been widely used in assessing exposure to mutagens and carcinogens. One of the extensively studied genotoxins is benzo[alpha]pyrene (BaP). We studied the ability of BaP to induce SCE and CA in 16 glutathione S-transferase M1 (GSTM1)-positive and 15 GSTM1-null indivi
Genetics and Molecular Biology. Publicado em: 2006
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33. APLICABILIDADE DE MEMÓRIA LÓGICA COMO FERRAMENTA COADJUVANTE NO DIAGNÓSTICO DAS DOENÇAS GENÉTICAS
This study has involved the interaction among knowledge in very distinctive areas, or else: informatics, engineering e genetics, emphasizing the building of a taking decision backing system methodology. The aim of this study has been the development of a tool to help in the diagnosis of chromosomal aberrations, presenting like tutorial model the Turner Syndr
Publicado em: 2006
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34. In vivo evaluation of the mutagenic potential and phytochemical characterization of oleoresin from Copaifera duckei Dwyer
We characterized the chemical constituents of Copaifera duckei oleoresin and used dermal application to Wistar rats to evaluated its possible mutagenic and cytotoxic activities on peripheral blood reticulocytes and bone marrow cells. Chemical characterization of the oleoresin revealed the presence of sesquiterpene hydrocarbons, an unidentified neutral diterp
Genetics and Molecular Biology. Publicado em: 2005-12
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35. Cytogenetic study of Brazilian patients with myelodysplastic syndrome (MDS)
Bone marrow cytogenetic studies were performed on 93 patients with primary myelodysplastic syndrome (MDS) diagnosed at the Clinical Hospital of the Federal University of Paraná, Brazil. Chromosomal alterations were observed in 69% of the patients. Monosomy of chromosome 7, deletions of 7q, 5q, 12p and 20q, rearrangements of 11q23 and trisomies of chromosome
Genetics and Molecular Biology. Publicado em: 2005-12
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36. Effects of H2O2, Fe2+ and Fe3+ on curcumin-induced chromosomal aberrations in CHO cells
The effects of H2O2, Fe2+ and Fe3+ on curcumin-induced clastogenicity were evaluated in CHO cells. Curcumin combined with H2O2 did not increase the chromosomal aberrations more than expected based on a simple additive effect. In contrast, the combination of curcumin-Fe significantly decreased the total number of chromosomal aberrations and the number of abno
Genetics and Molecular Biology. Publicado em: 2005-03