Chromosomal Aberrations
Mostrando 13-24 de 214 artigos, teses e dissertações.
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13. Investigação de fatores genéticos na etiologia de fendas orofaciais típicas / Investigation of genetic factors on the etiology of orofacial clefts typical
Typical oral cleft (TOC) is a prevalent and heterogeneous group of congenital defects with multiple etiologies, which remain unknown in several cases. Population studies detected several genes related to TOC. An individualized investigation, involving different laboratorial tools at same time, is an approach that can contribute on the etiological characteriz
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2012
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14. Role of p53 codon 72 polymorphism in chromosomal aberrations and mitotic index in patients with chronic hepatitis B
Polymorphisms of the p53 gene, which participates in DNA repair, can affect the functioning of the p53 protein. The Arg and Pro variants in p53 codon 72 were shown to have different regulation properties of p53-dependent DNA repair target genes that can affect various levels of cytogenetic aberrations in chronic hepatitis B patients. The present study aimed
Braz J Med Biol Res. Publicado em: 2012-11
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15. Estudo das alteraÃÃes hematolÃgicas, bioquÃmicas e genotÃxicas induzidas por agrotÃxicos em agricultores do estado do Piauà / STUDY OF POSSIBLE GENETIC CHANGES INDUCED BY PESTICIDES IN FARMERS IN THE STATE OF PIAUÃ
Exposure to pesticides represents a potential risk to human health. In addition to poisoning, these compounds may interact with DNA, causing degenerative diseases, including cancer. The risk assessment for pesticides was conducted in the municipalities of Picos, Piripiri, Barras and Josà de Freitas with farm workers (exposed group) and 55 administrative off
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/09/2011
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16. Biomonitoramento GenÃtico de Agricultores expostos a Pesticidas nos MunicÃpios de Tianguà e Ubajabra Cearà / Biomonitoring genetic of farmers exposed to pesticides in the municipalities of Tiangua and Ubajara (CearÃ, Brazil).
Nos Ãltimos anos, o uso de pesticidas na agricultura tem aumentado e associaÃÃes entre a exposiÃÃo a produtos quÃmicos agrÃcolas e danos ao DNA e cÃncer tem sido relatados. O Brasil à um dos lÃderes mundiais na utilizaÃÃo de pesticidas, no entanto, estudos que avaliem o impacto da exposiÃÃo ocupacional a pesticidas sobre a incidÃncia e mortali
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/08/2011
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17. Biomonitoramento genÃtico de indivÃduos expostos ocupacionalmente a pesticidas no povoado Vila Bessa, municÃpio de ConceiÃÃo do JacuÃpe, Bahia / Genetic biomonitoring of individuals occupationally exposed to pesticides in the village Vila Bassa, municipality of ConceiÃÃo do JacuÃpe, Bahia
The high consumption of pesticides in Brazil and all over the world have lead researches to relate this exposition to possible genetic and health damages in rural workers. Studies reveal that cancer is considered a genetic disease, once it results of the mutation accrual in genes involved with control of proliferation and cellular differentiation or mutation
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/11/2009
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18. Toxicity and genotoxicity of wastewater from gasoline stations
The toxicity and genotoxicity of wastewater from eight gasoline stations in Brasília, Brazil's capital city, was studied by assessing chromosomal aberrations, chromosomal malsegregation and the mitotic index in Allium cepa root cells, and the occurrence of micronucleus and nuclear abnormalities in peripheral erythrocytes of tilapia fish (Oreochromis nilotic
Genetics and Molecular Biology. Publicado em: 06/11/2009
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19. AvaliaÃÃo de aberraÃÃes cromossÃmicas em bovinos (Bos taurus taurus) infectados pelo papilomavÃrus bovino
Bovine papillomavirus (BPV) is represented by 10 papillomavirus subtypes, epiteliotropic or mucosotropic, which are transmitted among bovines through contaminated blood and ephitelial contact. This virus may be in a latent form on host lymphocytes, triggering chromosomal instabilities. In this context, this study aimed to evaluate chromosomal aberrations whi
Publicado em: 2009
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20. MLL leukemia-associated rearrangements in peripheral blood lymphocytes from healthy individuals
Chromosomal translocations are characteristic of hematopoietic neoplasias and can lead to unregulated oncogene expression or the fusion of genes to yield novel functions. In recent years, different lymphoma/leukemia-associated rearrangements have been detected in healthy individuals. In this study, we used inverse PCR to screen peripheral lymphocytes from 10
Genetics and Molecular Biology. Publicado em: 2009
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21. Genotoxicity assessment of a pharmaceutical effluent using four bioassays
Pharmaceutical industries are among the major contributors to industrial waste. Their effluents when wrongly handled and disposed of endanger both human and environmental health. In this study, we investigated the potential genotoxicity of a pharmaceutical effluent, by using the Allium cepa, mouse- sperm morphology, bone marrow chromosome aberration (CA) and
Genetics and Molecular Biology. Publicado em: 2009
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22. Preferential induction of MLL (Mixed Lineage Leukemia) rearrangements in human lymphocyte cultures treated with etoposide
Topoisomerase II inhibitors are effective chemotherapeutic agents in the treatment of cancer, in spite of being associated with the development of secondary leukemia. Our purpose was to determine the effects of etoposide on different genomic regions, aiming at discovering whether there are preferential sites which can be targeted by this drug in peripheral l
Genetics and Molecular Biology. Publicado em: 2009
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23. Cryptic mosaicism involving a second chromosome X in patients with Turner syndrome
The high abortion rate of 45,X embryos indicates that patients with Turner syndrome and 45,X karyotype could be mosaics, in at least one phase of embryo development or cellular lineage, due to the need for the other sex chromosome presence for conceptus to be compatible with life. In cases of structural chromosomal aberrations or hidden mosaicism, convention
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-05
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24. Chromosomal aberrations in peripheral lymphocytes from male native miners working in the Peruvian Andes
We analyzed the frequency of chromosomal aberrations in peripheral lymphocytes from underground miners from the Casapalca (n = 8, mean age = 45 y, range = 36 y to 55 y) and Bellavista (n = 8, mean age = 28 y, range 23 y to 34 y) high-altitude mining camps in the Peruvian Andes. This population was occupationally exposed to heavy metals such as lead and zinc
Genetics and Molecular Biology. Publicado em: 2007