Chromatographic Validation
Mostrando 1-12 de 102 artigos, teses e dissertações.
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1. An Eco-Friendly Proposal by Integrating Chromatographic Fingerprinting and Multivariate Control Chart in a Non-Target Analysis to Evaluate Grape Juices from Different Farming Practices
A potential eco-friendly method without organic solvents is presented by integrating a chromatographic fingerprint and multivariate control chart based on Q residuals to differentiate grape juices from different farming practices. The sample preparation was only water dilution, and the mobile phase was water acidified with sulfuric acid, which can be readily
Journal of the Brazilian Chemical Society. Publicado em: 2022
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2. Development and Validation of a Gas Chromatographic Method for the Quantification of Minor Alkaloids in Cocaine
The quantification of minor alkaloids in seized cocaine can provide information for drug profiling and law enforcement initiatives. This work presents the development and validation of an analytical method to quantitate minor alkaloids in cocaine samples using gas chromatography with flame ionization detector, after derivatization. The method was validated i
J. Braz. Chem. Soc.. Publicado em: 2021-04
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3. Methodology Development and Validation of Amphotericin B Stability by HPLC-DAD
The high worldwide consumption of antibiotics and their complex impurity profiles has drawn the attention of the scientific community to the development and validation of stability methods for these drugs. Amphotericin B is an antibiotic that is a natural fermentation product of bacterium Streptomyces nodosus, used as a broad-spectrum antifungal agent, and i
J. Braz. Chem. Soc.. Publicado em: 2020-05
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4. HPLC-PDA method validated for the determination of hibalactone in Hydrocotyle umbellata subterraneous parts and its ultrasound-assisted extraction optimization
ABSTRACT In this work, we developed and validated a HPLC-PDA method for the quantification of hibalactone in Hydrocotyle umbellata L., Araliaceae, subterraneous parts extracts and optimized its ultrasound-assisted extraction. Chromatographic separations were carried out with an isocratic mobile phase of acetonitrile/methanol/water (10:65:25), a flow of 0.8 m
Rev. bras. farmacogn.. Publicado em: 27/05/2019
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5. Validation of the Dual-path Platform chromatographic immunoassay (DPP® CVL rapid test) for the serodiagnosis of canine visceral leishmaniasis
BACKGROUND Visceral leishmaniasis is a major public health challenge in South America, and dogs are its main urban reservoir. OBJECTIVE Validation of the canine Dual-path Platform immunoassay for canine visceral leishmaniasis (DPP® CVL) for a sample set composed of 1446 dogs from different Brazilian endemic areas. METHODS A well-defined reference standard b
Mem. Inst. Oswaldo Cruz. Publicado em: 01/11/2018
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6. A sensitive bioanalytical method development and validation of cabozantinib in human plasma by LC-ESI-MS/MS
ABSTRACT A simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the quantification of cabozantinib (CZ) in human plasma using cabozantinib-d4 (CZD4) as an internal standard (IS). Chromatographic separation was performed on Xbridge C18, 50 x 4.6 mm, 5 mm column with an isocratic mobile phase compose
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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7. Determination of Target Pesticide Residues in Tropical Fruits Employing Matrix Solid-Phase Dispersion (MSPD) Extraction Followed by High Resolution Gas Chromatography
A simple method based on matrix solid-phase dispersion (MSPD) extraction and gas chromatography with electron-capture detection (GC-ECD) is employed to determine pesticide residues in the following tropical fruits: banana, mango, melon, papaya and pineapple. In the MSPD proposed method, C18, silica gel and ethyl acetate presented the best results in the extr
J. Braz. Chem. Soc.. Publicado em: 2018-05
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8. Development and Validation of a Rapid and Reliable RP-HPLC-PDA Method for the Quantification of Six Diterpenes in Copaifera duckei, Copaifera reticulata and Copaifera multijuga Oleoresins
Oleoresins from Copaifera species are extensively used in folk medicine in Brazil, which are employed mainly in the production of cosmetic formulations in Brazil, North America and Europe. Considering the lack of validated analytical methods for the analyses of diterpenes in Copaifera oleoresins, it was developed a validated and reliable reversed-phase high-
J. Braz. Chem. Soc.. Publicado em: 2018-04
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9. Identification and quantification of genipin and geniposide from Genipa americana L. by HPLC-DAD using a fused-core column
Abstract In this work, it was developed a fast, simple and selective method for quantification of genipin and geniposide from unripe fruits of genipap, which are known as natural colorants, blue and yellow, respectively. The compounds separation was performed in a fused-core C18 column using as mobile phase water (A) and acetonitrile (B) both acidified with
Food Sci. Technol. Publicado em: 19/03/2018
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10. Development and validation of stability indicating liquid chromatographic (RP-HPLC) method for estimation of ubidecarenone in bulk drug and formulations using quality by design (QBD) approach
ABSTRACT A novel, accurate, precise and economical stability indicating Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) method, was developed and validated for the quantitative determination of ubidecarenone (UDC) in bulk drug, UDC marketed formulation and UDC loaded cubosomes (CBMs) nanocarriers through Response surface methodology (RSM) desi
Braz. J. Pharm. Sci.. Publicado em: 05/03/2018
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11. FOURIER TRANSFORM INFRARED SPECTROSCOPY, THERMOGRAVIMETRIC ANALYSIS, SCANNING ELECTRON MICROSCOPY AS SUPPORTING TOOLS IN QUALITY CONTROL OF ANTIPARASITICS
This study shows that Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and scanning electron microscopy (SEM) can be used as supporting tools for the evaluation of the quality of antiparasitics. In addition, an analytical methodology was developed and validated to quantify simultaneously thiabendazole (TB), febantel (FB), tol
Quím. Nova. Publicado em: 2018-03
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12. Validation of a photostability indicating method for quantification of furanocoumarins from Brosimum gaudichaudii soft extract
ABSTRACT A validation study of a reverse-phase high-performance liquid chromatographic assay for the quantification of two furanocoumarins (psoralen and bergapten) in soft extract obtained from Brosimum gaudichaudii Trécul, Moraceae, roots was conducted. The developed method was sensitive, rapid, reproducible, easy and precise, and showed linearity (r > 0.9
Rev. bras. farmacogn.. Publicado em: 2018-01