Chromatin
Mostrando 13-24 de 4535 artigos, teses e dissertações.
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13. Antineoplastic potential of the aqueous crude extract of Eugenia uniflora L. in human cervical cancer
Abstract Considering the high prevalence of human cervical cancer and the adverse effects of the available treatments, it is important to develop studies involving plants. Eugenia uniflora L. is a Brazilian native plant widely used in folk medicine and some biological effects have already been described. In this study, we investigated the biologicals effects
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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14. Heterochromatin distribution and histone modification patterns of H4K5 acetylation and H3S10 phosphorylation in Capsicum L.
Abstract We evaluated domesticated Capsicum pepper species from Brazil using classical and molecular cytogenetic techniques, and describe here for the first time their immunostaining patterns using anti-H4K5ac and anti-H3S10ph antibodies. All accessions showed 2n = 24 chromosomes with metacentric and submetacentric morphologies. CMA3 patterns ranged from fou
Crop Breed. Appl. Biotechnol.. Publicado em: 2018-04
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15. Antimicrobial activity and acetylcholinesterase inhibition by extracts from chromatin modulated fungi
ABSTRACT Major health challenges as the increasing number of cases of infections by antibiotic multiresistant microorganisms and cases of Alzheimer's disease have led to searching new control drugs. The present study aims to verify a new way of obtaining bioactive extracts from filamentous fungi with potential antimicrobial and acetylcholinesterase inhibitor
Braz. J. Microbiol.. Publicado em: 2018-03
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16. Identification of the difference in the pathogenesis in heart failure arising from different etiologies using a microarray dataset
OBJECTIVES: Clinically, patients with chronic heart failure arising from different etiologies receive the same treatment. However, the prognoses of these patients differ. The purpose of this study was to elucidate whether the pathogenesis of heart failure arising from different etiologies differs. METHODS: Heart failure-related dataset GSE1145 was obtained
Clinics. Publicado em: 2017-10
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17. DNA methylation modulates H19 and IGF2 expression in porcine female eye
Abstract The sexually dimorphic expression of H19/IGF2 is evolutionarily conserved. To investigate whether the expression of H19/IGF2 in the female porcine eye is sex-dependent, gene expression and methylation status were evaluated using quantitative real-time PCR (qPCR) and bisulfite sequencing PCR (BSP). We hypothesized that H19/IGF2 might exhibit a differ
Genet. Mol. Biol.. Publicado em: 06/03/2017
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18. Epigenetic modifications and their relation to caste and sex determination and adult division of labor in the stingless bee Melipona scutellaris
Abstract Stingless bees of the genus Melipona, have long been considered an enigmatic case among social insects for their mode of caste determination, where in addition to larval food type and quantity, the genotype also has a saying, as proposed over 50 years ago by Warwick E. Kerr. Several attempts have since tried to test his Mendelian two-loci/two-allele
Genet. Mol. Biol.. Publicado em: 02/03/2017
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19. Effects of perinatal exposure to nonylphenol on delivery outcomes of pregnant rats and inflammatory hepatic injury in newborn rats
The current study aimed to investigate the effects of perinatal exposure to nonylphenol (NP) on delivery outcome of pregnant rats and subsequent inflammatory hepatic injury in newborn rats. The pregnant rats were divided into 2 groups: control group (corn oil) and NP exposure group. Thirty-four pregnant rats were administered NP or corn oil by gavage from th
Braz J Med Biol Res. Publicado em: 08/12/2016
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20. Methylation of the Sox9 and Oct4 promoters and its correlation with gene expression during testicular development in the laboratory mouse
Abstract Sox9 and Oct4 are two important regulatory factors involved in mammalian development. Sox9, a member of the group E Sox transcription factor family, has a crucial role in the development of the genitourinary system, while Oct4, commonly known as octamer binding transcription factor 4, belongs to class V of the transcription family. The expression of
Genet. Mol. Biol.. Publicado em: 04/07/2016
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21. Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma
Abstract: Histological subtypes of basal cell carcinoma have biological, evolutionary and distinct prognostic behavior. The analysis of characteristics of the nucleus can provide data on their cellular physiology and behavior. The authors of this study evaluated nuclear morphological parameters and textural patterns of chromatin from different subtypes of ba
An. Bras. Dermatol.. Publicado em: 2015-12
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22. Tissue apoptosis in mice infected with
Leptospira interrogans serovar IcterohaemorrhagiaeAbstract Background: This investigation aimed to evaluate the occurrence of some apoptotic features induced by
Leptospira interrogans serovar Icterohaemorrhagiae infection in young BALB/c mice during 2, 4, 7, 10, 14 and 21 days post-infection (dpi).Methods: The animals were
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/08/2015
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23. Epigenetic Modifications: Therapeutic Potential in Cancer
Epigenetic modifications and alterations in chromatin structure and function contribute to the cumulative changes observed as normal cells undergo malignant transformation. These modifications and enzymes (DNA methyltransferases, histone deacetylases, histone methyltransferases, and demethylases) related to them have been deeply studied to develop new drugs,
Braz. arch. biol. technol.. Publicado em: 2015-08
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24. Simultaneous Administration of Dexamethasone and Vitamin E Reversed Experimental Varicocele-induced Impact in testicular tissue in Rats; Correlation with Hsp70-2 Chaperone Expression
ABSTRACTPurpose:This study aimed to investigate the protective effects of isolated and co-administration of vitamin E (VitE) and dexamethasone (DEX) on varicocele (VCL)-induced damages in testicular tissue.Materials and Methods:Wistar rats were divided into five groups (n=6), including; control-sham, non-treated VCL-induced, VitE-treated VCL-induced (VitE, 1
Int. braz j urol.. Publicado em: 2015-08