Choroidal Neovascularization
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. Avaliação da eficácia e segurança do uso de radioterapia intraocular com estrôncio 90 e bevacizumabe no tratamento de pacientes portadores de degeneração macular relacionada à idade, forma exsudativa / Three-year safety and visual acuity results of epimacular straontium-90*ytrium90 brachytherapy with bevacizumab for the treatment of sobfoveal chorodoidal neovascularization secondary to agerelated macular degerenation
Objetivo: Avaliar a eficácia e segurança da braquiterapia epimacular com estrôncio 90 e bevacizumabe intravítreo para tratamento da neovascularização coróidea subfoveal secundária à degeneração macular relacionada à idade exsudativa, e observar seus efeitos na acuidade visual e espessura macular, em 36 meses de seguimento. Metodologia: Foram estu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/03/2012
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2. Avaliação da eficácia e segurança do uso de radioterapia intraocular com estrôncio 90 e bevacizumabe no tratamento de pacientes portadores de degeneração macular relacionada à idade, forma exsudativa / Three-year safety and visual acuity results of epimacular straontium-90*ytrium90 brachytherapy with bevacizumab for the treatment of sobfoveal chorodoidal neovascularization secondary to agerelated macular degerenation
Objetivo: Avaliar a eficácia e segurança da braquiterapia epimacular com estrôncio 90 e bevacizumabe intravítreo para tratamento da neovascularização coróidea subfoveal secundária à degeneração macular relacionada à idade exsudativa, e observar seus efeitos na acuidade visual e espessura macular, em 36 meses de seguimento. Metodologia: Foram estu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/03/2012
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3. Quantitative evaluation of experimental choroidal neovascularization by confocal scanning laser ophthalmoscopy: fluorescein angiogram parallels heparan sulfate proteoglycan expression
The objective of the present study was to develop a quantitative method to evaluate laser-induced choroidal neovascularization (CNV) in a rat model using Heidelberg Retina Angiograph 2 (HRA2) imaging. The expression of two heparan sulfate proteoglycans (HSPG) related to inflammation and angiogenesis was also investigated. CNV lesions were induced with argon
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-07
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4. Comparação entre o perímetro de hiperacuidade preferencial e a tela de Amsler em diferentes estágios de degeneração macular relacionada à idade
A Degeneração Macular Relacionada à Idade (DMRI) constitui a principal causa de cegueira legal no mundo ocidental, em faixas etárias superiores a 50 anos. A DMRI é classificada em forma não-neovascular e forma neovascular. Esta última caracteriza-se pela presença da neovascularização de coróide (NVC), sendo responsável por 80% dos casos de ceguei
Publicado em: 2007
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5. Genetic loci that control the size of laser-induced choroidal neovascularization
Angiogenesis is controlled by a balance between stimulators and inhibitors. We propose that the balance, as well as the general sensitivity of the endothelium to these factors, varies from individual to individual. Indeed, we have found that individual mouse strains have dramatically different responses to growth factor-induced neovascularization. Quantitati
The Federation of American Societies for Experimental Biology.
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6. Apolipoprotein E allele-dependent pathogenesis: A model for age-related retinal degeneration
Age-related macular degeneration (AMD) is a late-onset, multifactorial, neurodegenerative disease of the retina and the leading cause of irreversible vision loss in the elderly in the Western world. We describe here a murine model that combines three known AMD risk factors: advanced age, high fat cholesterol-rich (HF-C) diet, and apolipoprotein E (apoE) geno
National Academy of Sciences.
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7. S156C Mutation in Tissue Inhibitor of Metalloproteinases-3 Induces Increased Angiogenesis*
Tissue Inhibitor of metalloproteinases-3 (TIMP-3) is a potent matrix-bound angiogenesis inhibitor. Mutations in TIMP-3 cause Sorsby Fundus Dystrophy, a dominant inherited, early onset macular degenerative disease, with choroidal neovascularization causing a loss of vision in the majority of patients. Here we report that expression of S156C TIMP-3 mutation in
American Society for Biochemistry and Molecular Biology.
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8. Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1–3 of angiostatin reduce retinal neovascularization
Neovascular diseases of the retina include age-related macular degeneration and diabetic retinopathy, and together they comprise the leading causes of adult-onset blindness in developed countries. Current surgical, pharmaceutical, and laser therapies for age-related macular degeneration (AMD) rarely result in improved vision, do not significantly prevent neo
National Academy of Sciences.
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9. Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration
Age-related macular degeneration (AMD) is the leading cause of blindness after age 55 in the industrialized world. Severe loss of central vision frequently occurs with the exudative (wet) form of AMD, as a result of the formation of a pathological choroidal neovasculature (CNV) that damages the macular region of the retina. We tested the effect of an immunot
The National Academy of Sciences.
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10. Autologous transplantation of genetically modified iris pigment epithelial cells: A promising concept for the treatment of age-related macular degeneration and other disorders of the eye
Age-related macular degeneration (ARMD) is the leading cause for visual impairment and blindness in the elder population. Laser photocoagulation, photodynamic therapy and excision of neovascular membranes have met with limited success. Submacular transplantation of autologous iris pigment epithelial (IPE) cells has been proposed to replace the damaged retina
The National Academy of Sciences.
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11. Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies1
Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid involved in multiple physiological processes. Importantly, dysregulated S1P levels are associated with several pathologies, including cardiovascular and inflammatory diseases and cancer. This report describes the successful production and characterization of a murine monoclonal antibody, LT1002,
The American Society for Biochemistry and Molecular Biology.