Cholinesterase Inhibition
Mostrando 1-12 de 42 artigos, teses e dissertações.
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1. An Expedient Synthesis of Tacrine-Squaric Hybrids as Potent, Selective and Dual-Binding Cholinesterase Inhibitors
The restoration of acetylcholine levels in the brain by inhibition of cholinesterases is currently the most successful therapeutic strategy to treat neurodegenerative disorders. In this context, tacrine has been largely investigated as a starting scaffold for the development of promising new anticholinesterases compounds for the treatment of neurodegenerativ
J. Braz. Chem. Soc.. Publicado em: 2020-05
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2. Psychotria viridis: Chemical constituents from leaves and biological properties
ABSTRACT The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stig
An. Acad. Bras. Ciênc.. Publicado em: 2017-06
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3. In vitro evaluation of the effect of botanical formulations used in the control of Aedes aegypti L. (Diptera: Culicidae) on liver enzymes.
Abstract: INTRODUCTION: Dengue fever is a viral disease transmitted by the Aedes aegypti Linn. (1792) (Diptera: Culicidae) mosquito, which is endemic in several regions of Brazil. Alternative methods for the control of the vector include botanical insecticides, which offer advantages such as lower environmental contamination levels and less likelihood of re
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-12
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4. Cholinesterase inhibitory activity and structure elucidation of a new phytol derivative and a new cinnamic acid ester from Pycnanthus angolensis
ABSTRACT The leaves of Pycnanthus angolensis (Welw.) Warb., Myristicaceae, are used as memory enhancer and anti-ageing in Nigerian ethnomedicine. This study aimed at evaluating the cholinesterase inhibitory property as well as isolates the bioactive compounds from the plant. The acetylcholinesterase and butyrylcholinesterase inhibitory potentials of extracts
Rev. bras. farmacogn.. Publicado em: 2016-08
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5. Aminonaphthoquinone Mannich Bases Derived from Lawsone and Their Copper(II) Complex Derivatives: Synthesis and Potential Cholinesterase Inhibitors as Identified by On-flow Assay
A new series of Mannich bases derived from 2-hydroxy-1,4-naphthoquinone (lawsone), substituted benzaldehydes and two primary amines, and their Cu2+ complexes were synthesized and evaluated for their potential as selective cholinesterase inhibitors (ChEIs). Immobilized capillary enzyme reactors (ICERs) bearing butyrylcholinesterase (BChE) and acetylcholineste
J. Braz. Chem. Soc.. Publicado em: 2016-03
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6. Pesticide use and cholinesterase inhibition in small-scale agricultural workers in southern Brazil
Realizou-se um estudo transversal controlado, com hortifruticultores, durante o período de outubro de 2009 a outubro de 2010, a fim de caracterizar o uso de praguicidas, estabelecer o perfil sócio demográfico e analisar a atividade das colinesterases em trabalhadores rurais do sul do Brasil. Os dados foram obtidos de 173 trabalhadores e 179 controles. Um
Braz. J. Pharm. Sci.. Publicado em: 2014-12
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7. Acute electrophysiologic consequences of pyridostigmine inhibition of cholinesterase in humans
The cardiovascular electrophysiologic basis for the action of pyridostigmine, an acetylcholinesterase inhibitor, has not been investigated. The objective of the present study was to determine the cardiac electrophysiologic effects of a single dose of pyridostigmine bromide in an open-label, quasi-experimental protocol. Fifteen patients who had been indicated
Publicado em: 2011
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8. Seleção de fungos de decomposição branca para a redução da toxicidade do acefato / White Fungi for Reduction of Acephate Toxicity
O Brasil está entre os principais países consumidores de agrotóxicos, sendo o Estado de Goiás um colaborador em potencial devido à grande produção de tomate industrial. Dentre os agrotóxicos mais utilizados, destaca-se o organofosforado Acefato com características toxicológicas capazes de contaminar os seres vivos e o meio ambiente. Várias são as
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/08/2010
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9. Acute electrophysiologic consequences of pyridostigmine inhibition of cholinesterase in humans
The cardiovascular electrophysiologic basis for the action of pyridostigmine, an acetylcholinesterase inhibitor, has not been investigated. The objective of the present study was to determine the cardiac electrophysiologic effects of a single dose of pyridostigmine bromide in an open-label, quasi-experimental protocol. Fifteen patients who had been indicated
Brazilian Journal of Medical and Biological Research. Publicado em: 15/01/2010
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10. Seleção de fungos de decomposição branca para a redução da toxicidade do acefato / White Fungi for Reduction of Acephate Toxicity
O Brasil está entre os principais países consumidores de agrotóxicos, sendo o Estado de Goiás um colaborador em potencial devido à grande produção de tomate industrial. Dentre os agrotóxicos mais utilizados, destaca-se o organofosforado Acefato com características toxicológicas capazes de contaminar os seres vivos e o meio ambiente. Várias são as
Publicado em: 2010
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11. Composição química e atividade biológica das folhas e frutos de Triphasia trifolia
The chemical composition of the essential oils from leaves and fruits of Triphasia trifolia was analyzed by GC-FID and GC-MS. The major constituents of oil obtained from leaves were sabinene (35.4%) and myrcene (34.1%), while the prevalent compounds in oil from fruits were sabinene (37.2%), beta-pinene (23.95) and gamma-terpinene (16.3%). Both oils showed mo
Química Nova. Publicado em: 2008
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12. ContribuiÃÃo ao conhecimento quÃmico de plantas do Nordeste do Brasil: Cordia piauhiensis Fresen e Triphsia trifolia (Burm. f.) P.Wils / Contribution to Northeast the chemical Knowledge of plants of Brazil: Cordia piauhiensis Fresen e Triphasia trifolia (Burm. f.) P. Wils
The chemical composition of the essential oils from leaves and fruits of Triphasia trifolia were analyzed by GC-FID and GC-MS. The major constituents identified for oils obtained from leaves were sabinene (39.2 and 33.8%) and myrcene (21.9 and 33.6%), while the prevalent compounds detected in fruit oils were sabinene (35.5 and 22.8%), -pinene (21.2 a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/09/2007