Chiral Pharmaceuticals
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. FÁRMACOS QUIRAIS EM DIFERENTES MATRIZES AMBIENTAIS: OCORRÊNCIA, REMOÇÃO E TOXICIDADE
In recent decades, the occurrence of pharmaceuticals in the environment has been widely reported due to their high frequency and recalcitrance in many cases. Concerning the chiral pharmaceuticals (CPs) in environmental matrices, the stereochemistry is often neglected and enantiomers are determined together as unique molecules. However, it is well known that
Quím. Nova. Publicado em: 2016-06
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2. Catálise assimétrica no Brasil: desenvolvimento e potencialidades para o avanço da indústria química brasileira
The preparation of enantiomerically pure or enriched substances is of fundamental importance to pharmaceutical, food, agrochemical, and cosmetics industries and involves a growing market of hundreds of billions of dollars. However, most chemical processes used for their production are not environmentally friendly because in most cases, stoichiometric amounts
Quím. Nova. Publicado em: 2013
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3. Glicerol: um breve histórico e aplicação em sínteses estereosseletivas
Presently glycerol is considered a co-product of biodiesel industry. As the biodiesel production is exponentially increasing, glycerol generated from the transesterification of vegetable oils and fats is also being produced on a large scale, and turned out to be essential seeking for novel alternatives to the consumption of the extra volume, in crude and/or
Química Nova. Publicado em: 2011
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4. Eletrophoretic and spectrometric characterization of Cinchona extracts of use phytoterapic and cosmetic / Caracterização eletroforética e espectrométrica de extratos de Cinchona de uso fitoterápico e cosmético
Every year, malaria kills about one million people. According to OMS, 3.3 billion people, half of the world population, are exposed to the disease, mostly in underdeveloped countries. The pharmaceuticals used in the treatment of malaria include: chloroquine, primaquine, quinine, mefloquine, doxyclyne, clindamicina and artemisin. The increased resistance of t
Publicado em: 2010
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5. Utilização do D-manitol em síntese orgânica
D-mannitol is used in several fields including food, pharmaceuticals, cosmetics and textiles being an important carbohydrate found widespread in nature. Due to its chirality, it is largely used in organic synthesis with several applications, such as ligands, polymers, chiral pool, for preparation of small chiral building blocks, key intermediates in total sy
Química Nova. Publicado em: 2009
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6. Simulated moving-bed adsorption for separation of racemic mixtures
The two enantiomers that constitute a racemate have different activities when employed as pharmaceuticals. Due to this fact, fully recognized today, the pharmaceutical industry has been forced to market pure enantiomers instead of the racemic mixture whenever a chiral compound is involved. The simulated moving bed (SMB) is a chromatographic process that, unl
Brazilian Journal of Chemical Engineering. Publicado em: 2004-01
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7. Separação enantiomérica de fármacos em medicamentos por cromatografia líquida com fase estacionária quiral / Direct enantiomeric separation of drugs in pharmaceutical by high performance liquid chromatography with chiral stationary phase
The majority of the therapeutic agents, frequently prescribed, are formulated and commercialized as racemic mixture, even so for some of them, it has been demonstrated that the pharmacological and/or toxic effect are confined only to one of the enantiomer. Besides, it is well known that the enantiomers can present different pharmacokinetic and pharmacodynami
Publicado em: 2002
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8. Redução fenilcetonas por fermento de pão imobilizado
We have studied the stereospecific reduction of phenylketones by IMBY (immobilized baker s yeast) that not only gives alcohols with high optical yields but can be reused in further reactions after regeneration of the cofator NADH. The chiral alcohols are valuable intermediates for pharmaceuticals synthesis. We have used chrysotile and montmorillonite as supp
Publicado em: 1992