Chemokine Receptor Ccr5
Mostrando 1-12 de 224 artigos, teses e dissertações.
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1. Comparison of the editing patterns and editing efficiencies of TALEN and CRISPR-Cas9 when targeting the human CCR5 gene
Abstract The human C-C chemokine receptor type-5 (CCR5) is the major transmembrane co-receptor that mediates HIV-1 entry into target CD4+ cells. Gene therapy to knock-out the CCR5 gene has shown encouraging results in providing a functional cure for HIV-1 infection. In gene therapy strategies, the initial region of the CCR5 gene is a hotspot for producing fu
Genet. Mol. Biol.. Publicado em: 19/03/2018
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2. Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease
Abstract INTRODUCTION: Elucidating the molecules involved in the inflammatory process of chronic Chagas disease may allow identification of treatment targets. METHODS: The ex vivo phenotypic expression of chemokine receptors CCR1, CCR3, CCR4, CCR5, CXCR2, CXCR3, CXCR4, and CXCR5 on the CD4+ and CD8+ T-cells of patients with chronic Chagas cardiomyopathy
Rev. Soc. Bras. Med. Trop.. Publicado em: 2017-09
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3. Distribution of the CCR5delta32 allele (gene variant CCR5) in Rondônia, Western Amazonian region, Brazil
Since around 1723, on the occasion of its initial colonization by Europeans, Rondonia has received successive waves of immigrants. This has been further swelled by individuals from northeastern Brazil, who began entering at the beginning of the twentieth century. The ethnic composition varies across the state according to the various sites of settlement of e
Genetics and Molecular Biology. Publicado em: 06/01/2012
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4. O papel das quimiocinas CCL3, CCL2 e seus receptores na movimentação dentária ortodôntica
Orthodontic tooth movement (OTM) is achieved by the remodeling of periodontal ligament (PDL) and alveolar bone in response to mechanical loading. This process is regulated by pro-inflammatory mediators, such as cytokines and chemokines. CCL2, CCL3 and CCL5 are chemokines involved in osteoclastogenesis and are upregulated in periodontium after mechanical load
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/11/2011
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5. Expression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients
Leprosy is caused by Mycobacterium leprae, which induces chronic granulomatous infection of the skin and peripheral nerves. The disease ranges from the tuberculoid to the lepromatous forms, depending on the cellular immune response of the host. Chemokines are thought to be involved in the immunopathogenesis of leprosy, but few studies have investigated the e
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-12
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6. The role of CCR5 in oral infection by Toxoplasma gondii / Papel de CCR5 na infecção oral por Toxoplasma gondii
Toxoplasma gondii é um protozoário intracelular obrigatório que causa a toxoplasmose. Em modelo experimental, camundongos C57BL/6 infectados por via oral com 100 cistos de T. gondii, cepa ME-49, desenvolvem sérias lesões intestinais similares as observadas em doenças inflamatórias intestinais. Ao invadir as células epiteliais intestinais, o parasito
Publicado em: 2010
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7. Analysis of the CCR5 gene coding region diversity in five South American populations reveals two new non-synonymous alleles in Amerindians and high CCR5*D32 frequency in Euro-Brazilians
The CC chemokine receptor 5 (CCR5) molecule is an important co-receptor for HIV. The effect of the CCR5*D32 allele in susceptibility to HIV infection and AIDS disease is well known. Other alleles than CCR5*D32 have not been analysed before, neither in Amerindians nor in the majority of the populations all over the world. We investigated the distribution of t
Genetics and Molecular Biology. Publicado em: 16/01/2009
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8. AvaliaÃÃo da mutaÃÃo ccr5A32 do receptor da B â quimiocina como marcador genÃtico-histÃrico na populaÃÃo de Triunfo Pernambuco / AvaliaÃÃo da mutaÃÃo ccr5A32 do receptor da B â quimiocina como marcador genÃtico-histÃrico na populaÃÃo de Triunfo Pernambuco
The CMKBR5 encodes a 7-transmembrane G-protein-coupled chemokine receptor (CCR5) in macrophages and lymphocytes. A 32 base pair deletion in the coding region of the ccr5 gene has been reported in individuals, homozygous for this deletion, who seem to be resistant to HIV-1 infection. This mutation has a single recent origin in Northeastern Europe, where the h
Publicado em: 2008
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9. Análise de células CD4+CD25+FoxP3+ no timo de camundongos infectados pelo Trypanosoma cruzi. / Analysis of cells CD4 CD25 FoxP3 in the thymus of mice infected for the Trypanosoma cruzi.
Natural regulatory T cells arise in the thymus during the normal process of differentiation and participate in the control of auto and alloimmune responses. Specifically in parasite infections, these cells may have antagonist roles, in favor of the microorganism or the host. Previous studies from our Laboratory revealed that acute Trypanosoma cruzi (T. cruzi
Publicado em: 2008
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10. CCR5 genotypes and progression to HIV disease in perinatally infected children
The CCR5 molecule, a chemokine receptor, is the most important co-receptor for macrophage-tropic HIV-1. A 32-bp deletion in the gene encoding CCR5 (CCR5-del32) confers nearly complete resistance to HIV-1 infection in homozygotes, and slows the rate of progression to AIDS in heterozygous adults. The aim of this study was to describe the CCR5 genotypes and the
Brazilian Journal of Infectious Diseases. Publicado em: 2007-04
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11. Correlation of chemokine ligands and its receptors with lymph node metastasis in Head and Neck Squamous Cell Carcinoma / Proteínas ósseas envolvidas na calcificação vascular de ratos urêmicos, paratireoidectomizados, alimentados com dieta rica e pobre em fósforo associada à infusão fixa de paratormônio
Local invasion and lymph nodal spread impact in the outcome of Head and Neck squamous cell carcinoma (HNSCC) patients (pts). We determined CXCR1-5, CCR7 and CX3CR1 mRNA expression by means of RNAse protection assay in 98 HNSCC primary tumors and 91 adjacent mucosa and 26 metastatic lymph nodes, correlating this data with outcome. CXCL12 and CCL19/CCL21, liga
Publicado em: 2007
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12. Correlação dos ligantes de quimiocinas e de seus respectivos receptores em relação à invasão de linfonodos nos carcinomas epidermóides em cabeça e pescoço / Correlation of chemokine ligands and its receptors with lymph node metastasis in Head and Neck Squamous Cell Carcinoma
Tanto a invasão local como o comprometimento de linfonodos cervicais tem grande impacto na sobrevida de pacientes portadores de carcinomas epidermóides de cabeça e pescoço. Em nosso trabalho nós primeiramente determinamos a expressão dos receptores de quimiocinas de CXCR1 a CXCR5, além de CCR7 e CX3CR1 pelo método do ensaio de proteção à ribonucle
Publicado em: 2007