Central Depressant
Mostrando 25-36 de 88 artigos, teses e dissertações.
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25. Dual effect of disopyramide on atrial and atrioventricular conduction and refractory periods.
Disopyramide has been shown in conditions of cholinergic blockade to have a depressant effect upon sinus node automaticity and the atrial refractoriness. It also prolongs atrioventricular conduction and increases atrioventricular refractoriness. These effects may often be masked in vivo by the anticholinergic effects of the drug.
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26. A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.
We have previously described a subpopulation of patients with septic shock who had a reversible depression of radionuclide-determined left ventricular ejection fraction (EF). To investigate the mechanism of this myocardial depression, an in vitro model of mammalian myocardial cell performance was established employing primary spontaneously beating rat myocar
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27. Nomifensine: effect in Parkinsonian patients not receiving levodopa.
A clinical trial using the anti-depressant nomifensine in Parkinsonism is reported. Eighteen subjects not receiving levodopa participated. The drug had a small, but significant anti-Parkinsonian effect. No troublesome side effects were encountered. In the treatment of Parkinsonism, nomifensine may be considered as an alternative to amantadine or anticholiner
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28. Adenosine increases synaptic facilitation in the in vitro rat hippocampus: evidence for a presynaptic site of action.
The effect of adenosine on paired synaptic responses was characterized in the CA1 region of the rat hippocampus in vitro. Adenosine increased the degree of synaptic facilitation at a 40 ms conditioning-testing interval under all conditions tested. Even when the stimulation intensity was increased so as to counteract the direct depressant effect of adenosine
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29. Identification, characterization, and gene expression profiling of endotoxin-induced myocarditis
In septic shock, reversible cardiac dysfunction starts within 24 h. Myocardial depressant factors are thought to cause myocyte dysfunction, resulting in alterations of intrinsic cardiac function. Nitric oxide is a myocardial depressant factor candidate. Here we identify endotoxin-induced myocarditis (EIM) a previously uncharacterized pathophysiological entit
National Academy of Sciences.
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30. Gentamicin blockade of slow Ca++ channels in atrial myocardium of guinea pigs.
Cardiac dysfunction is occasionally detected in patients undergoing treatment with amino-glycoside antibiotics, however, the mechanism responsible for the negative inotropic effect of these agents has not been identified. In the present investigation electrically driven left atria of guinea pigs were used to study the effects of gentamicin on calcium ion (Ca
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31. Echocardiographic assessment of cats anesthetized with xylazine-sodium pentobarbital.
Left ventricular echocardiographic parameters in cats were recorded, measured and analyzed to study the effects of a combination of xylazine and sodium pentobarbital on left ventricular function. The depressant effects of a combination of xylazine and sodium pentobarbital on the left ventricular dimension at end diastole, the percent change in minor diameter
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32. Central nervous system site of action for the respiratory depressant effect of diacetylmorphine (heroin) in the cat.
The purpose of our study was to identify central nervous system sites involved in the respiratory depressant effect of drugs that stimulate opioid receptors. Diacetylmorphine (heroin) was administered into several cerebroventricular regions of chloralose-anesthetized cats, while monitoring pulmonary ventilation with a Fleisch pneumotachograph. Administration
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33. Interactions between the effects of adenosine and calcium on synaptic responses in rat hippocampus in vitro.
The effect of adenosine on synaptic responses in the in vitro rat hippocampus was examined. As has been previously described, adenosine had a profound depressant effect on synaptic transmission at excitatory synapses on the CA1 pyramidal cells. Although adenosine also produced small decreases in the amplitude of the presynaptic fibre spike, this was unable t
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34. A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor
Background: The neurochemical and biological effects of antidepressant medications have become better defined over the last decade. When the anti-depressant bupropion was introduced in the United States in 1989, the specific pharmacologic basis of its clinical effects was uncertain. Research conducted over the past decade has significantly advanced the under
Physicians Postgraduate Press.
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35. Recognition sites for chemotactic repellents of Bacillus subtilis.
Repellents of Bacillus subtilis include many membrane-active compounds, such as uncouplers of oxidative phosphorylation, local anesthetics, chlorpromazine (a central nervous system depressant), and tetraphenylboron (a lipophilic anion). Normally, bacteria swim smoothly, and occasionally tumble, but addition of repellent causes all bacteria to tumble, then la
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36. Effect of the beta adrenergic blocking agent propranolol on essential tremor
A double blind trial of a single 40 mg dose of the beta adrenergic blocking agent propranolol in the treatment of essential tremor produced significant reduction of tremor in four of five patients, but this effect was transient and had considerably diminished within four hours. A month's double blind clinical trial of propranolol, in a dose of 30 mg three ti