Cddp
Mostrando 1-12 de 26 artigos, teses e dissertações.
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1. Study of the protective effect of dexamethasone on cisplatin-induced ototoxicity in rats
Abstract Purpose: To evaluate the ability of dexamethasone to protect against cisplatin (CDDP)-induced ototoxicity. Methods: Male Wistar rats were divided into the following three groups: 1) Control (C): 6 animals received intraperitoneal (IP) saline solution, 8 ml/kg/day for four days; 2) C + CDDP: 11 animals received 8 ml/kg/day of IP saline and, 90 mi
Acta Cir. Bras.. Publicado em: 2017-10
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2. MicroRNA-340-5p modulates cisplatin resistance by targeting LPAATβ in osteosarcoma
MicroRNAs (miRNAs) play an important role in drug resistance and modulate the efficiency of chemotherapy. A recent study indicated that miR-340 functions as a tumor suppressor in various types of cancer. However, the role of miR-340 in chemotherapy has not been reported yet. In this study, we found that miR-340 enhanced cisplatin (CDDP)-induced cell death. I
Braz J Med Biol Res. Publicado em: 20/04/2017
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3. Perfil audiológico de pacientes tratados de câncer na infância,
Resumo Objetivo: Caracterizar as alterações auditivas após o tratamento do câncer, segundo o tipo de tratamento identificando os fatores preditivos. Método: Foram avaliados prospectivamente duzentos pacientes que tiveram cancer na infância. A idade média ao diagnóstico foi de 6 anos e à avaliação audiométrica de 21 anos de idade. O tratamento i
Braz. j. otorhinolaryngol.. Publicado em: 2016-12
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4. Comparative study of curcumin and curcumin formulated in a solid dispersion: Evaluation of their antigenotoxic effects
Abstract Curcumin (CMN) is the principal active component derived from the rhizome of Curcuma longa (Curcuma longa L.). It is a liposoluble polyphenolic compound that possesses great therapeutic potential. Its clinical application is, however, limited by the low concentrations detected following oral administration. One key strategy for improving the solubil
Genet. Mol. Biol.. Publicado em: 03/11/2015
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5. Crude alkaloid extract of Rhazya stricta inhibits cell growth and sensitizes human lung cancer cells to cisplatin through induction of apoptosis
There is an urgent need to improve the clinical management of non-small cell lung cancer (NSCLC), one of the most frequent causes of cancer-related deaths in men and women worldwide. Rhazya stricta, an important medicinal plant used in traditional Oriental medicine, possesses anti-oxidant, anti-carcinogenic and free radical scavenging properties. This study
Genet. Mol. Biol.. Publicado em: 01/02/2013
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6. Antigenotoxic activity of diet compounds and their influence in the expression of genes involved in response to oxidative stress / Atividade antigenotóxica de compostos da dieta e sua influência na expressão de genes de resposta ao estresse oxidativo
Os pigmentos naturais, além de fornecerem cor e beleza aos diferentes organismos, desempenham importantes funções e ações biológicas, como as funções vitais de fotossíntese, respiração celular e a ação antioxidante. Assim, o presente estudo investigou os potenciais citotóxicos, genotóxicos e protetores dos pigmentos naturais clorofila b (CLb)
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2012
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7. Avaliação da toxicidade aguda e atividade antitumoral de lipossomas pH-sensíveis de longa circulação contendo cisplatina
Cancer is one of the main causes of mortality in the world, with chemotherapy being a valuable alternative for the disease treatment. Cisplatin (CDDP) is one of the most active cytotoxic agents and has been commonly used as first line chemotherapy against several tumors. However, the effectiveness of its clinical use is limited by severe side effects, mainly
Publicado em: 2010
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8. Avaliação pré-clínica de lipossomas pH-sensíveis de longa circulação contendo cisplatina
cis-Diamminedichloroplatinum (II) or cisplatin (CDDP) is one of the anticancer agents most widely used in the treatment of solid tumors. However, the effectiveness of its clinical use is hampered by the induction of severe side effects and its tendency to provoke chemoresistance. To circumvent these inconveniences, drug delivery systems, such as long-circula
Publicado em: 2008
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9. Ensaio clínico randomizado para avaliação do efeito otoprotetor do extrato de Ginkgo Biloba, por meio das emissões otoacústicas por produto de distorção, em pacientes sob tratamento com cisplatina
The ototoxicity is an alteration caused by drugs that compromises the auditory and vestibular functions. The cisplatin (CDDP) is a potent antineoplastic agent used for the treatment of cancer in both adults and children although it has several side effects. The cisplatin ototoxicity is a dose-limiting condition. Current opinion is that cisplatin ototoxicity
Publicado em: 2008
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10. Cytotoxic effect of essential oil of thyme (Thymus broussonettii) on the IGR-OV1 tumor cells resistant to chemotherapy
The anti-tumor effect of the Moroccan endemic thyme (Thymus broussonettii) essential oil (EOT) was investigated in vitro using the human ovarian adenocarcinoma IGR-OV1 parental cell line OV1/P and its chemoresistant counterparts OV1/adriamycin (OV1/ADR), OV1/vincristine (OV1/VCR), and OV1/cisplatin (OV1/CDDP). All of these cell lines elicited various degrees
Brazilian Journal of Medical and Biological Research. Publicado em: 2007-11
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11. Preparation and cytotoxicity of cisplatin-containing liposomes
We encapsulated cisplatin into stealth pH-sensitive liposomes and studied their stability, cytotoxicity and accumulation in a human small-cell lung carcinoma cell line (GLC4) and its resistant subline (GLC4/CDDP). Since reduced cellular drug accumulation has been shown to be the main mechanism responsible for resistance in the GLC4/CDDP subline, we evaluated
Brazilian Journal of Medical and Biological Research. Publicado em: 14/06/2007
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12. Avaliação dos efeitos da cirurgia de citorredução e quimio-hipertermia intraperitoneal no tratamento de 40 mulheres com carcinoma epitelial avançado ou recidivado do ovario
Objetivos: Avaliar a sobrevida, morbidade, toxicidade, mortalidade e fatores prognósticos em mulheres com carcinoma epitelial avançado e/ou recidivado do ovário, tratadas com a terapia combinada de cirurgia de citorredução (CCR) e quimio-hipertermia intraperitoneal (QHIP). Métodos: Quarenta mulheres portadoras de carcinoma epitelial avançado e/ou reci
Publicado em: 2006