Cardiac Collagen
Mostrando 1-12 de 88 artigos, teses e dissertações.
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1. YAP activation promotes the transdifferentiation of cardiac fibroblasts to myofibroblasts in matrix remodeling of dilated cardiomyopathy
Yes-associated protein (YAP) is an important regulator of cellular proliferation and transdifferentiation. However, little is known about the mechanisms underlying myofibroblast transdifferentiation in dilated cardiomyopathy (DCM). We investigated the role of YAP in the pathological process of cardiac matrix remodeling. A classic model of DCM was established
Braz J Med Biol Res. Publicado em: 23/11/2018
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2. Resistance training attenuates salt overload-induced cardiac remodeling and diastolic dysfunction in normotensive rats
Elevated salt intake induces changes in the extracellular matrix collagen, leading to myocardial stiffness and impaired relaxation. Resistance training (RT) has been used as a remarkably successful strategy in the treatment of heart disease. Therefore, the aim of this study was to investigate the effects of RT on preventing pathological adaptation of the lef
Braz J Med Biol Res. Publicado em: 07/08/2017
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3. Interval and continuous exercise enhances aerobic capacity and hemodynamic function in CHF rats
OBJECTIVE: The aim of the present study was to compare the effects of continuous versus interval aerobic exercise training on hemodynamic parameters, cardiac remodeling, and maximal exercise capacity (MEC) in chronic heart failure (CHF) rats.METHOD: Twenty-four male Wistar rats were subjected to myocardial infarction (MI) surgery. Five weeks post MI, the ani
Braz. J. Phys. Ther.. Publicado em: 01/09/2015
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4. Time-course effects of aerobic exercise training on cardiovascular and renal parameters in 2K1C renovascular hypertensive rats
Exercise training (Ex) has been recommended for its beneficial effects in hypertensive states. The present study evaluated the time-course effects of Ex without workload on mean arterial pressure (MAP), reflex bradycardia, cardiac and renal histology, and oxidative stress in two-kidney, one-clip (2K1C) hypertensive rats. Male Fischer rats (10 weeks old; 150�
Braz J Med Biol Res. Publicado em: 11/08/2015
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5. Changes in cardiac aldosterone and its synthase in rats with chronic heart failure: an intervention study of long-term treatment with recombinant human brain natriuretic peptide
The physiological mechanisms involved in isoproterenol (ISO)-induced chronic heart failure (CHF) are not fully understood. In this study, we investigated local changes in cardiac aldosterone and its synthase in rats with ISO-induced CHF, and evaluated the effects of treatment with recombinant human brain natriuretic peptide (rhBNP). Sprague-Dawley rats were
Braz J Med Biol Res. Publicado em: 11/07/2014
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6. Periostin as a modulator of chronic cardiac remodeling after myocardial infarction
OBJECTIVE: After acute myocardial infarction, during the cardiac repair phase, periostin is released into the infarct and activates signaling pathways that are essential for the reparative process. However, the role of periostin in chronic cardiac remodeling after myocardial infarction remains to be elucidated. Therefore, the objective of this study was to
Clinics. Publicado em: 2013-10
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7. Aerobic exercise improves the inflammatory profile correlated with cardiac remodeling and function in chronic heart failure rats
OBJECTIVE: The aim of the present study was to evaluate the effect of 8 weeks of aerobic exercise training on cardiac functioning and remodeling and on the plasma levels of inflammatory cytokines in chronic heart failure rats. METHODS: Wistar rats were subjected to myocardial infarction or sham surgery and assigned to 4 groups: chronic heart failure train
Clinics. Publicado em: 2013-06
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8. Exercise training prior to myocardial infarction attenuates cardiac deterioration and cardiomyocyte dysfunction in rats
OBJECTIVES: The present study was performed to investigate 1) whether aerobic exercise training prior to myocardial infarction would prevent cardiac dysfunction and structural deterioration and 2) whether the potential cardiac benefits of aerobic exercise training would be associated with preserved morphological and contractile properties of cardiomyocytes
Clinics. Publicado em: 2013-04
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9. The effect of beta-blockade on myocardial remodelling in Chagas' cardiomyopathy
OBJECTIVE: Chagas' disease has spread throughout Latin America because of the high rate of migration among these countries. Approximately 30% of Chagas' patients will develop cardiomyopathy, and 10% of these will develop severe cardiac damage leading to heart failure. Beta-blockade improves symptoms and survival in heart failure patients; however, its effica
Clinics. Publicado em: 2012-09
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10. Influência da integridade dos barorreceptores nos ajustes morfofuncionais cardíacos à hipertensão espontânea em ratos / Influence of baroreceptor integrity on cardiac morpho-functional adjustments to spontaneous hypertension in rats
It has been demonstrated that reduced baroreflex sensitivity is an independent marker of mortality risk. The arterial baroreflex plays an important role in the maintenance of the moment-to-moment stability of blood pressure (BP). Although the contribution of blood pressure variability (BPV) to cardiovascular morbidity and mortality is well established, the m
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/07/2011
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11. Cardiac and renal effects induced by different exercise workloads in renovascular hypertensive rats
We examined the effect of exercise training (Ex) without (Ex 0%) or with a 3% workload (Ex 3%) on different cardiac and renal parameters in renovascular hypertensive (2K1C) male Fisher rats weighing 150-200 g. Ex was performed for 5 weeks, 1 h/day, 5 days/week. Ex 0% or Ex 3% induced similar attenuation of baseline mean arterial pressure (MAP, 119 ± 5 mmHg
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-06
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12. Effects of spironolactone in spontaneously hypertensive adult rats subjected to high salt intake
OBJECTIVE: To evaluate the effect of spironolactone on ventricular stiffness in spontaneously hypertensive adult rats subjected to high salt intake. INTRODUCTION: High salt intake leads to cardiac hypertrophy, collagen accumulation and diastolic dysfunction. These effects are partially mediated by cardiac activation of the renin-angiotensin-aldosterone syste
Clinics. Publicado em: 2011