Carcinogens
Mostrando 1-12 de 373 artigos, teses e dissertações.
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1. Synchronous presentation of muscle-invasive urothelial carcinoma of bladder and peritoneal malign mesothelioma
ABSTRACT Introduction Cancer is one of the most important leading cause of death in man and woman in the world. The occurrence of new cancer has become more frequent in recent years due to strict screening protocols and occupational and environmental exposure to carcinogens. The incidence of secondary malignancies has also increased due to close medical fo
Int. braz j urol.. Publicado em: 02/09/2019
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2. Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases
Infection with human papillomaviruses is associated with a series of benign and malignant hyperproliferative diseases that impose a heavy burden on human populations. A subgroup of mucosal human papillomavirus types are associated with the majority of cervical cancers and a relevant fraction of vulvar, vaginal, anal, penile and head and neck carcinomas. Huma
Clinics. Publicado em: 06/09/2018
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3. GSTT1 and GSTM1 null variants in Mestizo and Amerindian populations from northwestern Mexico and a literature review
Abstract The GSTT1 and GSTM1 genes are key molecules in cellular detoxification. Null variants in these genes are associated with increase susceptibility to developing different types of cancers. The aim of this study was to determine the prevalence of GSTT1 and GSTM1 null genotypes in Mestizo and Amerindian individuals from the Northwestern region of Mexico
Genet. Mol. Biol.. Publicado em: 06/11/2017
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4. CARCINOGENICIDADE DE HIDROCARBONETOS POLICÍCLICOS AROMÁTICOS
The assessment of the carcinogenic potential of polycyclic aromatic hydrocarbons (PAH) is obtained by a principal component analysis (PCA) and quantitative structure-activity relationship (QSAR) using hydrophobic (LogP), stereo and electronic parameters (electron affinity, dipole moment and HOMO-LUMO gap) calculated from the AM1 method. The PAH-DNA interacti
Quím. Nova. Publicado em: 2016-08
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5. Dideoxy single allele-specific PCR - DSASP new method to discrimination allelic
Gastric cancer (GC) is a multifactorial disease with a high mortality rate in Brazil and worldwide. This work aimed to evaluate single nucleotide polymorphisms (SNP) rs1695, in the Glutathione S-Transferase Pi (GSTP1) gene in GC samples by comparative analysis Specific PCR - ASP and Dideoxy Single Allele-Specific PCR - DSASP methods. The DSASP is the propose
Braz. arch. biol. technol.. Publicado em: 2015-06
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6. Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
PURPOSE: To study the possible potentiation of the carcinogenic effects of ultraviolet radiation associated with an organophosphate pesticide. METHODS: Forty Wistar rats were assigned into four groups (n=10 each) randomized according to the procedures: group A received only UVR-B radiation; group B, UVR-B for eight weeks followed by a seven week period
Acta Cir. Bras.. Publicado em: 2014-01
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7. Carcinogenicidade do carbendazim e seus metabólitos
The carcinogenic potential of carbendazim and its metabolites was analyzed using statistical treatment of electronic parameters obtained from DFT/ 6-311++G(d,p) and AM1 calculations. The carcinogen-DNA interaction is described in the framework of the theory of unsynchronized resonance of covalent bond as a process of electron transfer involving the HOMO and
Quím. Nova. Publicado em: 2014
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8. Distribuição COM-Poisson na análise de dados de experimentos de quimioprevenção do câncer em animais
Experimentos que envolvem a indução química de substâncias cancerígenas em animais são comuns na área biológica. O interesse destes experimentos é, em geral, avaliar o efeito de uma substância quimiopreventiva na destruição das células danificadas. Neste tipo de estudo, duas variáveis de interesse são o número de tumores induzidos e seus temp
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/03/2012
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9. Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer
The arylamine N-acetyltransferase 2 (NAT2) enzymes detoxify a wide range of naturally occurring xenobiotics including carcinogens and drugs. Point mutations in the NAT2 gene result in the variant alleles M1 (NAT2 *5A), M2 (NAT2*6A), M3 (NAT2*7) and M4 (NAT2 *14A) from the wild-type WT (NAT2 *4) allele. The current study was aimed at screening genetic polymor
Genet. Mol. Biol.. Publicado em: 2012
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10. AvaliaÃÃo das AlteraÃÃes HematolÃgicas, BioquÃmicas e GenotÃxicas nos Trabalhadores Expostos à AgrotÃxicos em MunicÃpios do Estado do Piauà / Evaluation of Hematologic, Biochemical and Genotoxic Effects in Workers Exposed to Pesticide in Municipalities of PiauÃ
A utilizaÃÃo de agrotÃxicos na agricultura elevou rapidamente seu consumo, especialmente de forma indiscriminada, sendo o Brasil um dos maiores mercados, representando 16% da venda mundial. No PiauÃ, a expansÃo agrÃcola na regiÃo dos cerrados contribuiu para o aumento do seu uso, expondo os agricultores a danos ao DNA. O objetivo desse estudo foi aval
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/09/2011
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11. Estudo das alteraÃÃes hematolÃgicas, bioquÃmicas e genotÃxicas induzidas por agrotÃxicos em agricultores do estado do Piauà / STUDY OF POSSIBLE GENETIC CHANGES INDUCED BY PESTICIDES IN FARMERS IN THE STATE OF PIAUÃ
Exposure to pesticides represents a potential risk to human health. In addition to poisoning, these compounds may interact with DNA, causing degenerative diseases, including cancer. The risk assessment for pesticides was conducted in the municipalities of Picos, Piripiri, Barras and Josà de Freitas with farm workers (exposed group) and 55 administrative off
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/09/2011
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12. Polymorphisms of cytochrome P450 1A1, glutathione s-transferases M1 and T1 genes in ouangolodougou (Northern Ivory Coast)
In this study, the frequencies of CYP1A1, GSTM1, and GSTT1 gene polymorphisms were determined in 133 healthy individuals from Ouangolodougou, a small rural town situated in the north of the Ivory Coast. As appeared in several published studies, ethnic differences in these frequencies have been found to play an important role in the metabolism of a relevant n
Genetics and Molecular Biology. Publicado em: 02/07/2010