Cannabinoid
Mostrando 1-12 de 121 artigos, teses e dissertações.
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1. Cannabinoid receptor gene polymorphisms and cognitive performance in patients with schizophrenia and controls
Objective: To test the hypothesis that genetic variations of cannabinoid receptors contribute to the pathophysiology of cognitive deficits in schizophrenia. Methods: In this genetic association case-control study, cannabinoid receptor polymorphisms CNR1 rs12720071 and CNR2 rs2229579 were tested for association with neurocognitive performance in 69 patients
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. The endocannabinoid system in social anxiety disorder: from pathophysiology to novel therapeutics
Social anxiety disorder (SAD) is a highly prevalent psychiatric disorder that presents with an early age of onset, chronic disease course, and increased risk of psychiatric comorbidity. Current treatment options for SAD are associated with low response rates, suboptimal efficacy, and possible risk of adverse effects. Investigation of new neurobiological mech
Brazilian Journal of Psychiatry. Publicado em: 2022
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3. Association of FAAH p.Pro129Thr and COMT p.Ala72Ser with schizophrenia and comorbid substance use through next-generation sequencing: an exploratory analysis
Objective: Individuals with schizophrenia and substance use disorders have a poor prognosis and increased psychiatric symptoms. The present study aimed to explore the association of 106 genes in individuals with schizophrenia and comorbid substance use through a next-generation sequencing (NGS) analysis and different in silico algorithms. Methods: We includ
Brazilian Journal of Psychiatry. Publicado em: 2022
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4. Electrical stimulation of the posterior insular cortex induces opioid and cannabinoid-dependent antinociception and regulates glial cells in the spinal cord
RESUMO JUSTIFICATIVA E OBJETIVOS: Metade dos pacientes com dor neuropática são refratários aos tratamentos. A estimulação elétrica do córtex insular (EECI) posterior modula circuitos sensoriais e nociceptivos. Assim, este estudo avaliou os efeitos de uma faixa de frequências de EECI como tratamento em modelo animal de dor neuropática. MÉTODOS: Ra
BrJP. Publicado em: 2022
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5. Cannabinoid receptor-1 antagonism: a new perspective on treating a murine schistosomal liver fibrosis model
BACKGROUND Formation of schistosomal granulomata surrounding the ova can result in schistosomiasis-associated liver fibrosis (SSLF). The current standard of treatment is praziquantel (PZQ), which cannot effectively reverse SSLF. The role of the cannabinoid (CB) receptor family in liver fibrosis has recently been highlighted. OBJECTIVES This study aimed t
Mem. Inst. Oswaldo Cruz. Publicado em: 05/08/2019
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6. Potential Therapeutic Targets of the Endocannabinoid System in Common Neurodegenerative Disorders and Organic Acidemias
Abstract The cannabinoid chemistry is currently being addressed in preclinical approaches as a viable therapeutic alternative for the management of a wide range of signs, symptoms, and some biochemical hallmarks of many neurological pathologies (such as neuroinflammation and neurodegeneration). This clinical orientation is grounded on the consistent promisso
J. inborn errors metab. screen.. Publicado em: 16/05/2019
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7. Perspectives in veterinary medicine on the use of cannabinoids as complementary palliative therapy for pain in cancer patients
RESUMO: A dor no paciente com câncer é uma manifestação clínica importante que resulta em baixa perspectiva de vida e pior prognóstico. Esta dor pode estar relacionada ao tipo de tumor, à invasão em tecidos adjacentes, metástases, procedimentos diagnósticos e terapêuticos, com resposta variável à terapêutica analgésica. Muitos estudos têm cha
Cienc. Rural. Publicado em: 28/02/2019
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8. Analysis of Isomeric Cannabinoid Standards and Cannabis Products by UPLC-ESI-TWIM-MS: a Comparison with GC-MS and GC × GC-QMS
The Cannabis sativa L. plant has a complex chemical composition, containing various chemical compounds such as terpenes, sugars, hydrocarbons, steroids, flavonoids, and amino acids. Few works have attempted to identify the constitutional isomers of cannabinoids that are found in the plant. The present study reported the analysis of seven cannabinoid standard
J. Braz. Chem. Soc.. Publicado em: 2019-01
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9. What do Cochrane systematic reviews say about the use of cannabinoids in clinical practice?
ABSTRACT BACKGROUND: The therapeutic effects of cannabinoid compounds have been the center of many investigations. This study provides a synthesis on all Cochrane systematic reviews (SRs) that assessed the use of cannabinoids as a therapeutic approach. DESIGN AND SETTING: Review of SRs, conducted in the Discipline of Evidence-Based Medicine, Escola Pauli
Sao Paulo Med. J.. Publicado em: 22/10/2018
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10. Involvement of Gaba and Cannabinoid Receptors in Central Food Intake Regulation in Neonatal Layer Chicks: Role of CB1 and Gabaa Receptors
ABSTRACT Feeding behavior is regulated via a complex network which interacts via diverse signals from central and peripheral tissues. Endocannabinoids modulate release of GABA in a variety of regions of the central nervous system. Endocannabinoids and GABAergic system have an important role in the central regulation of appetite. Thus, the present study exami
Rev. Bras. Cienc. Avic.. Publicado em: 2017-06
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11. Rimonabant improves metabolic parameters partially attributed to restoration of high voltage-activated Ca2+ channels in skeletal muscle in HFD-fed mice
Cannabinoid type 1 receptor (CB1R) inhibition tends to be one of the promising strategies for the treatment of obesity and other related metabolic disorders. Although CB1R inhibition may cause adverse psychiatric effects including depression and anxiety, the investigation of the role of peripheral CB1R on weight loss and related metabolic parameters are urge
Braz J Med Biol Res. Publicado em: 04/05/2017
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12. A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems
Abstract Background Some peptides purified from the venom of the spider Phoneutria nigriventer have been identified as potential sources of drugs for pain treatment. In this study, we characterized the antinociceptive effect of the peptide PnPP-19 on the central nervous system and investigated the possible involvement of opioid and cannabinoid systems in i
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 19/01/2017