Cannabinoid
Mostrando 13-24 de 121 artigos, teses e dissertações.
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13. The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data
Objective: Schizophrenia is a multifactorial disorder. It is known that a combination of extensive multiple common alleles may be involved in its etiology, each contributing with a small to moderate effect, and, possibly, some rare alleles with a much larger effect size. We aimed to perform a systematic review of association studies between schizophrenia (a
Rev. Bras. Psiquiatr.. Publicado em: 12/01/2017
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14. A metanandamida, um agonista canabinóide, protege a linhagem de neuroblastoma neuro2A da morte celular induzida por peróxido de hidrogênio. / The methanandamide, a cannabinoid agonist, protect the lineage of neuro 2A cell death induced by hydrogen peroxide.
Neurodegenerative diseases are progressive disorder affecting specific neuronal populations in the central nervous system, leading to neuronal death. Several factors contribute to the development of neurodegenerative diseases, including increased free radical formation and / or oxidative stress. The cannabinoid system has been suggested as an important syste
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/07/2012
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15. Participation of cannabinoid receptors in peripheral nociception induced by some NSAIDs
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been used extensively to control inflammatory pain. Several peripheral antinociceptive mechanisms have been described, such as opioid system and NO/cGMP/KATP pathway activation. There is evidence that the cannabinoid system can also contribute to the in vivo pharmacological effects of ibuprofen and indometha
Braz J Med Biol Res. Publicado em: 2012-12
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16. Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters
This paper presents an up-to-date review of the evidence indicating that atypical neurotransmitters such as nitric oxide (NO) and endocannabinoids (eCBs) play an important role in the regulation of aversive responses in the periaqueductal gray (PAG). Among the results supporting this role, several studies have shown that inhibitors of neuronal NO synthase or
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-04
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17. Análise forense: pesquisa de drogas vegetais interferentes de testes colorimétricos para identificação dos canabinoides da maconha (Cannabis Sativa L.)
Marijuana (Cannabis sativa L.) is the most cultivated, trafficked and consumed illicit drug worldwide. Estimates indicate 10% of individuals experiencing marijuana become daily users, and 20-30% use it weekly. Around 489 natural compounds have been identified in this plant, of which 70 are cannabinoids, responsible for psychic effects. The most relevant cann
Quím. Nova. Publicado em: 2012
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18. Efeitos da eletroacupuntura sobre a expressão de receptores canabinóides CB1 em camundongos abstinentes ao etanol / Electroacupuncture effects over CB1 cannabinoid receptor in ethanol withdrawal mice
Existe uma importante interação entre o álcool e o sistema endocanabinóide. Além de modular o efeito de reforço positivo do álcool, o receptor canabinóide CB1 também está envolvido nos estados afetivos negativos da abstinência. Recentemente foi descrito que este receptor é ativado pelo procedimento de acupuntura, o qual vem sendo utilizado para a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2011
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19. Neurobiologia da Cannabis: do sistema endocanabinoide aos transtornos por uso de Cannabis
OBJETIVOS: Diante das lacunas na efetividade das terapêuticas para transtornos por uso de Cannabis, a droga ilícita mais consumida no mundo, este trabalho propõe-se a rever os conhecimentos sobre o substrato neuroanatômico, biomolecular e celular do sistema endocanabinoide, descrever os mecanismos de neuroplasticidade dependente dos canabinoides e relaci
Jornal Brasileiro de Psiquiatria. Publicado em: 2011
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20. Cannabinoids, anxiety, and the periaqueductal gray
The use of Cannabis sativa by humans dates back several thousand years, for both its psychotomimetic and potential medicinal properties. As scientific research methods developed, the cannabinoids present in this herb were characterized, as well as their complex interface with the human central nervous system, provided by the activation of specific receptors.
Psychology & Neuroscience. Publicado em: 2010-06
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21. Effect of (-)-∆9-tetrahydrocannabinoid on the hepatic redox state of mice
(-)-∆9-Tetrahydrocannabinol (∆9-THC), a psychoactive component of marijuana, has been reported to induce oxidative damage in vivo and in vitro. In this study, we administered ∆9-THC to healthy C57BL/6J mice aged 15 weeks in order to determine its effect on hepatic redox state. Mice were divided into 3 groups: ∆9-THC (N = 10), treated with 10 mg/kg bo
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-04
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22. 1-(2,4-dichlorophenyl-1H-pyrazoles: Synthesis, Structural Analysis and Interactions with Cannabinoid Receptors CB1 / 1-(2,4-Diclorofenil)-1H-pirazóis: Síntese, Análise Estrutural e Interação com os Receptores Canabinóides CB1
A method to obtain fourteen enones [EtO2CC(O)C(R2)=C(R1)OR, where R = H, Me; R1 = Pr, Ph, 4-MeOC6H4, 4-MeC6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 4-NO2C6H4, Fur- 2-yl; R2 = H; R1,R2 = -(CH2)3-, -(CH2)4-, -(CH2)5-, -(CH2)6-, 3,4-dihydronaphthalen-2-yl] from acylation of acetals with ethyl oxalyl chloride is reported. The cyclocondensation reaction of these substrat
Publicado em: 2010
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23. A obesidade diminui a resposta de artérias mesentéricas de resistência a agonistas canabinóides. / Obesity decreases the response of resistance mesenteric arteries to cannabinoid agonists.
Este estudo investigou o efeito da obesidade sobre a resposta de artérias mesentéricas a agonistas canabinóides. Ratos obesos Zucker (OZRs) apresentaram reduzido relaxamento à anandamida, aos agonistas CB1 e CB2 e à capsaicina (agonista vanilóide) comparados aos controles (LZRs). A expressão dos receptores CB1 e CB2 foi menor em OZRs. O bloqueio de ca
Publicado em: 2010
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24. Anandamide injected into the lateral ventricle of the brain inhibits submandibular salivary secretion by attenuating parasympathetic neurotransmission
Our objective was to determine the effect of arachidonylethanolamide (anandamide, AEA) injected intracerebroventricularly (icv) into the lateral ventricle of the rat brain on submandibular gland (SMG) salivary secretion. Parasympathetic decentralization (PSD) produced by cutting the chorda tympani nerve strongly inhibited methacholine (MC)-induced salivary s
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-06