Cancer Genetics
Mostrando 1-12 de 114 artigos, teses e dissertações.
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1. The effect of mutation status, pathological features and tumor location on prognosis ın patients with colorectal cancer
SUMMARY OBJECTIVE: Colorectal cancer is the most common malignancy of the gastrointestinal tract. It is the third most common tumor in both genders and the second reason of cancer-related deaths. In recent years, tumor location has gained importance as a prognostic indicator. In this study, we aimed to analyze if there was a prognostic effect of tumor locat
Rev. Assoc. Med. Bras.. Publicado em: 2021-02
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2. Albinism: epidemiology, genetics, cutaneous characterization, psychosocial factors
Abstract Oculocutaneous albinism is an autosomal recessive disease caused by the complete absence or decrease of melanin biosynthesis in melanocytes. Due to the reduction or absence of melanin, albinos are highly susceptible to the harmful effects of ultraviolet radiation and are at increased risk of actinic damage and skin cancer. In Brazil, as in other par
An. Bras. Dermatol.. Publicado em: 09/12/2019
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3. Information and Diagnosis Networks – tools to improve diagnosis and treatment for patients with rare genetic diseases
Abstract Brazil is a country of continental dimensions and most genetic services are concentrated in the Southeast and South, including the Medical Genetics Service of the Hospital de Clínicas de Porto Alegre (MGS/HCPA). As many areas on the country do not have adequate medical genetics support, networks were designed to extend the service of the MGS/HCPA r
Genet. Mol. Biol.. Publicado em: 10/06/2019
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4. Repercussions of melatonin on the risk of breast cancer: a systematic review and meta-analysis
RESUMO O câncer de mama é comum em mulheres, mas sua etiologia ainda não é totalmente compreendida. Vários fatores podem contribuir para sua gênese, genética, estilo de vida e meio ambiente. A melatonina pode estar envolvida no processo de câncer de mama. Portanto, o objetivo deste estudo é avaliar a influência dos níveis de melatonina no câncer
Rev. Assoc. Med. Bras.. Publicado em: 03/06/2019
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5. Epidemiological science and cancer control
Epidemiological methods are essential for the discovery of cancer risks and prognostic factors as well as for the evaluation of cancer prevention measures. In this review, we discuss epidemiological surveillance procedures for data collection and processing to guide and evaluate the consequences of anticancer efforts for populations, assess the identificatio
Clinics. Publicado em: 21/09/2018
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6. The Brazilian Hereditary Cancer Network: historical aspects and challenges for clinical cancer genetics in the public health care system in Brazil
Genet. Mol. Biol.. Publicado em: 03/06/2016
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7. Oncogenetics service and the Brazilian public health system: the experience of a reference Cancer Hospital
Abstract The identification of families at-risk for hereditary cancer is extremely important due to the prevention potential in those families. However, the number of Brazilian genetic services providing oncogenetic care is extremely low for the continental dimension of the country and its population. Therefore, at-risk patients do not receive appropriate as
Genet. Mol. Biol.. Publicado em: 13/05/2016
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8. Identification of significant pathways in gastric cancer based on protein-protein interaction networks and cluster analysis
Gastric cancer is one of the most common and lethal cancers worldwide. However, despite its clinical importance, the regulatory mechanisms involved in the aggressiveness of this cancer are still poorly understood. A better understanding of the biology, genetics and molecular mechanisms of gastric cancer would be useful in developing novel targeted approaches
Genetics and Molecular Biology. Publicado em: 13/07/2012
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9. Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2
Multiple endocrine neoplasia type 2 is an inherited cancer syndrome characterized by tumors of thyroid and adrenal tissues. Germline mutations of the REarranged during Transfection (RET) proto-oncogene, leading to its unregulated activation, are the underlying cause of this disease. Multiple endocrine neoplasia type 2 has been a model in clinical cancer gene
Clinics. Publicado em: 2012
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10. Construção e caracterização de vetor adenoviral com promotor responsivo ao seu próprio transgene p53 e sua comparação com um vetor de promoção constitutiva. / Construction and characterization of an adenoviral vector responsive to its own p53 transgene in a comparison with a constitutive promoter vector.
Em sua maioria, estratégias de transferência gênica utilizam arranjos com promotores e transgenes funcionando de maneira independente entre si, como é o caso do amplamente utilizado promotor CMV. Nosso grupo foge dessa linha de promotores/transgenes independentes. Desenvolvemos uma nova estratégia de transferência gênica que combina estrategicamente a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/03/2011
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11. Genotoxicidade e indução de apoptose por Fluconazol em células de mamíferos in vitro
O Fluconazol é um antifúngico amplamente prescrito para combater candidíase e dermatomicoses, além de ser usado como medida profilática em transplantados, imunodeprimidos e pessoas com câncer. Apesar desse antimicótico já ser comercializado, é necessário farmacovigilância, que consiste em verificar efeitos prejudiciais dos medicamentos, visando pr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/01/2011
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12. Análise de polimorfismos em tumores gliais humanos / Polymorphisms Analysis in Human Glial Tumors
The Central nervous system tumors represent about 2% of all cancers. Although the incidence of CNS tumors is small compared with other cancers, these tumors are among the most serious human malignancies, because they affect the body responsible for coordination and integration of all organic activities. Gliomas are the most common tumors of the CNS. Despite
Publicado em: 2011