Butenolides
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. Acid-Catalyzed Z-E Isomerization of γ-Alkylidenebutenolides: An Experimental and DFT Study
The Z-E isomerization of γ-alkylidenebutenolide analogues to natural nostoclides and other natural butenolides was investigated using 1H nuclear magnetic resonance (NMR) and high performance liquid chromatography (HPLC) data as well as density functional theory (DFT) calculations at the wB97x-D/6-31G(d,p) level, including solvent effects with the polarizabl
J. Braz. Chem. Soc.. Publicado em: 2020-01
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2. Inibição do crescimento de microrganismos patogênicos induzida por butenolídeos análogos aos cadiolídeos
The increasing number of antibiotic resistant microorganisms requires the development of new drugs. In this context, natural cadiolides are promising leads as they present potent antimicrobial activity and low cytotoxicity. In this work we report the synthesis of 21 new cadiolide analogues. The synthesis involved a Diels−Alder cycloaddition/ cycloreversion
Quím. Nova. Publicado em: 15/08/2019
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3. Aplicações sintéticas do ácido mucobrômico e da 3,4-dibromofuran-2(5H)-ona
This review describes the use of two biomass-derivate butenolides as intermediates in organic synthesis, mucobromic acid and its reduced derivative 3,4-dibromofuran-2(5H)-one. The ambiphilic and ambident character of such butenolides make them versatile starting materials in the synthesis of natural and/or bioactive compounds. Thus, the reactions of mucobrom
Química Nova. Publicado em: 2011
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4. Arylation of β,γ-unsaturated lactones by a Heck-Matsuda reaction: an unexpected route to aryldiazene butenolides and pyridazinones
The palladium catalysed coupling of aryldiazonium salts with β-γ-unsaturated lactones under basic conditions has been investigated. Both (3H)-furanone and α-angelicalactone were evaluated as substrates in the Heck Matsuda reaction but both failed to afford the desired arylated butenolides. Under basic conditions, β-γ-unsaturated lactones generate highly
Química Nova. Publicado em: 2010
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5. Evaluation of biological potential of natural piperolídeos of Piper malacophyllum (C. Presl) C. DC. and synthetic analogues / Avaliação do pontencial biológico de piperolídeos naturais de Piper malacophyllum (C. Presl) C. DC. e de análogos sintéticos
Based on the powerful antifungal activity of piperolides (1 e 2) isolated from Piper malacophyllum leaves extracts, several analogues were synthesized aiming at establishing preliminary structure-activity relationship against Cladosporium cladosporioides, C. sphaerospermum and against epimastigote form of Trypanosoma cruzi. Phytochemical studies carried out
Publicado em: 2008
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6. Synthesis and Evaluation of the Phytotoxicity of News Butenolides Analogues of the Nostoclides. / Síntese e avaliação da fitotoxicidade de novos butenolídeos análogos aos nostoclídeos
The nostoclides belong to a class of natural compounds called γ-alkylidenebutenolides that have several representatives with biological application. To contribute to the study of this class of compounds, this present work aimed to synthesize new butenolides analogous to the nostoclides from furan-2 (5H)-one [8] and evaluate the phytotoxic activity of th
Publicado em: 2007
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7. Adição de nucleofilos a ions N-aciliminios quirais e reações de ciclização promovidas por Pd(0) / Nucleophilic addition to chiral N-acyliminium ions and palladium(0)-mediated cyclization reactions
The first part of this work described the addition of carbon nucleophiles to chiral N-acyliminium ions derived from tetrahydroisoquinoline. Once established for the racemic series, the methodology was explored with chiral N-acyliminium ions derived from (1R,2S)-(-)-trans-phenylcyclohexanol (97) and (1R,2S,5R)-(-)-8-phenylmenthol (98). The addition of allyltr
Publicado em: 2006