Bmp 6
Mostrando 37-48 de 92 artigos, teses e dissertações.
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37. Utilização da densitometria óssea como método de avaliação dos resultados da utilização de BMP bovina em artrodese de coluna em coelhos
As BMPs, proteínas indutoras de crescimento ósseo, desde o início de sua utilização, têm sido avaliadas em diferentes modelos experimentais objetivando determinar sua eficácia, sendo necessário o estabelecimento de métodos de avaliação que permitam melhor compreensão dos resultados. OBJETIVO: Este estudo tem por objetivo avaliar a utilização da
Acta Ortopédica Brasileira. Publicado em: 2005
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38. Avaliação clinica e histologica da eficacia de enxerto heterogeno organico bovino associado a proteina ossea morfogenetica de embrião bovino em cirurgia de levantamento de seio maxilar
O presente estudo teve como objetivo avaliar clinica e histologicamente o comportamento da associação entre uma matriz óssea orgânica bovina (Gen-Ox@) e uma proteína óssea morfogenética (BMP) derivada de embrião bovino (Gen-Pro@), quando comparada com enxerto ósseo autógeno em cirurgias para levantamento bilateral de seio maxilar. Foram operados 10
Publicado em: 2005
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39. "Avaliação da osteogênese com proteínas ósseas morfogenéticas (BMPs): análise em defeitos na calvária e ao redor de implantes de titânio em coelhos". / Osseointegration enhancement around titanium implants and calvarial reconstruction induced by bone morphogenetic proteins in rabbits
Objective. Study I:The aim of this study was to assess osteogenesis in cirurgically created skull defects in rabbits (Oryctolagus cuniculus) induced by bone morphogenetic proteins combined to the composite calcium carboante-collagen. Study II: Avaliate osteogenesis around titanium implants inserted in the rabbit tibia, induced by bone morphogenetic protein c
Publicado em: 2002
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40. Characterization of Wise Protein and Its Molecular Mechanism to Interact with both Wnt and BMP Signals*
Cross-talk of BMP and Wnt signaling pathways has been implicated in many aspects of biological events during embryogenesis and in adulthood. A secreted protein Wise and its orthologs (Sostdc1, USAG-1, and Ectodin) have been shown to modulate Wnt signaling and also inhibit BMP signals. Modulation of Wnt signaling activity by Wise is brought about by an intera
American Society for Biochemistry and Molecular Biology.
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41. Effect of bone morphogenetic protein-6 on macrophages
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor (TGF)-β superfamily which regulates bone formation, haematopoiesis and development. While TGF-β is known to be a negative regulator of the immune system, the effect of BMPs on the immune system is largely unknown. Herein, the effect of BMP-6 on the innate immune system was inv
Blackwell Science Inc.
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42. Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways
Extraembryonic ectoderm-derived factors instruct the pluripotent epiblast cells to develop toward a restricted primordial germ cell (PGC) fate during murine gastrulation. Genes encoding Bmp4 of the Dpp class and Bmp8b of the 60A class are expressed in the extraembryonic ectoderm and targeted mutation of either results in severe defects in PGC formation. It h
The National Academy of Sciences.
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43. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
Bone morphogenetic protein (BMP) receptors signal by phosphorylating Smad1, which then associates with Smad4; this complex moves into the nucleus and activates transcription. Here we report the existence of a natural inhibitor of this process, Smad6, a longer version of the previously reported JV15-1. In Xenopus embryos and in mammalian cells, Smad6 specific
Cold Spring Harbor Laboratory Press.
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44. Bone morphogenetic protein-6 induces the expression of inducible nitric oxide synthase in macrophages
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) superfamily. In the present study, we investigated the effect of BMPs on the production of inducible nitric oxide synthase (iNOS) in the murine macrophage cell line, RAW 264.7, and in mouse peritoneal macrophages. Among the BMPs, only BMP-6 induced iNOS expression in
Blackwell Science Inc.
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45. BMP4 is essential for lens induction in the mouse embryo
Vertebrate lens development is a classical model system for studying embryonic tissue interactions. Little is known, however, about the molecules mediating such inductive events. Here, we show that Bmp4, which is expressed strongly in the optic vesicle and weakly in the surrounding mesenchyme and surface ectoderm, has crucial roles during lens induction. In
Cold Spring Harbor Laboratory Press.
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46. Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads
Inhibitory Smads, i.e. Smad6 and Smad7, are potent antagonists of the BMP–Smad pathway by interacting with activated bone morphogenetic protein (BMP) type I receptors and thereby preventing the activation of receptor-regulated Smads, or by competing with activated R-Smads for heteromeric complex formation with Smad4. The molecular mechanisms that underlie
Oxford University Press.
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47. Bone Morphogenetic Protein 2-Induced Osteoblast Differentiation Requires Smad-Mediated Down-Regulation of Cdk6
Because a temporal arrest in the G1 phase of the cell cycle is thought to be a prerequisite for cell differentiation, we investigated cell cycle factors that critically influence the differentiation of mouse osteoblastic MC3T3-E1 cells induced by bone morphogenetic protein 2 (BMP-2), a potent inducer of osteoblast differentiation. Of the G1 cell cycle factor
American Society for Microbiology.
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48. Stable expression and characterization of N-terminal tagged recombinant human bone morphogenetic protein 15
Oocyte-derived growth factors are critically involved in multiple ovarian processes via paracrine actions. Although recombinant proteins have been applied to dissect the physiological functions of these factors, variation of activities among different protein preparations remains an issue. To further elucidate the roles of one of these growth factors, bone m
Oxford University Press.