Bioequivalence Study
Mostrando 25-36 de 53 artigos, teses e dissertações.
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25. Estimation of rosuvastatin in human plasma by HLPC tandem mass spectroscopic method and its application to bioequivalence study
Um método empregando LC-MS/MS foi desenvolvido para a análise de rosuvastatina em plasma humano, usando atorvastatina como padrão interno. Rosuvastatina é um fármaco para redução de lipídeos e prescrita para o tratamento do hipercolesterolemia e de dislipidimia. A extração em fase sólida (SPE) foi usada para purificação e pré-concentração do
Journal of the Brazilian Chemical Society. Publicado em: 2005-10
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26. Bioequivalence evaluation of tinidazole 500 mg tablets / Avaliação de bioequivalência de comprimidos contendo 500 mg de tinidazol
Tinidazole, 1-[2-(ethylsulphonyl)ethyl]-2-methyl-5-nitroimidazole, is a member of the 5-nitroimidazole class of antimicrobial agents with amoebicidal, giardicidal, trichomonicidal and anaerobic activity. The purpose of this study was to evaluate the bioequivalence of two brands of tinidazole 500mg tablets in healthy human volunteers. The procedure of bioequi
Publicado em: 2005
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27. Estudo de bioequivalencia de duas formulações de cefadroxil - capsula (500mg) em voluntarios sadios de ambos os sexos
The objective of this study is to compare the bioequivalence of Cefadroxil- capsule 500 mg formulated by Apotex of Brazil Ltda (test formulation) and Cefamox by LaboratoryBristol-Myers Squibb (reference formulation) in volunteers of both sexes. This study was necessary for the commercialization of medicines. The study was conducted with a randomized two-peri
Publicado em: 2005
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28. Estudo de bioequivalencia de duas formulações de cefadroxil - capsula (500mg) em voluntarios sadios de ambos os sexos
The objective of this study is to compare the bioequivalence of Cefadroxil- capsule 500 mg formulated by Apotex of Brazil Ltda (test formulation) and Cefamox by LaboratoryBristol-Myers Squibb (reference formulation) in volunteers of both sexes. This study was necessary for the commercialization of medicines. The study was conducted with a randomized two-peri
Publicado em: 2005
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29. Estudo de bioequivalencia de duas formulações de cefadroxil - capsula (500mg) em voluntarios sadios de ambos os sexos
The objective of this study is to compare the bioequivalence of Cefadroxil- capsule 500 mg formulated by Apotex of Brazil Ltda (test formulation) and Cefamox by LaboratoryBristol-Myers Squibb (reference formulation) in volunteers of both sexes. This study was necessary for the commercialization of medicines. The study was conducted with a randomized two-peri
Publicado em: 2005
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30. Estudo de bioequivalencia entre duas formulações de azitromicina utilizando a cromatografia liquida de alta eficiencia acoplada ao espectrometro de massa (LC-MS-MS)
Objective: To assess the bioequivalence of two azithromycin tablet formulations (Azitromicina 500 mg tablet fromEMS Indústria Farmacêutica, Brazil as test formulation and Zitromax@500 mg tablet from Laboratórios Pfizer, Brazil as reference formulation) in 25 healthy volunteers of both sexes. The study was conducted using an open, randomized two-period cro
Publicado em: 2005
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31. Desenvolvimento e validaÃÃo de metodologias analÃticas para estudo farmacocinÃtico comparativo de duas classes de fÃrmacos (anti-retroviral e penicilÃnico) em individuos sadios / Development and validation of analytical methodologies for two drugs classes (Antiretroviral and Penicillin) comparative pharmacokinetic study with healthy volunteers
De acordo com os dados da OrganizaÃÃo Mundial da SaÃde (OMS), mais de um terÃo da populaÃÃo mundial nÃo tem acesso a medicamentos. A partir do uso de medicamentos genÃricos, um nÃmero maior de pessoas poderia ter acesso a medicamentos mais baratos â o que ampliaria o padrÃo de saÃde e garantiria mais qualidade de vida. No caso particular de agent
Publicado em: 2005
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32. Intervalo de confiança para avaliação de bioequivalencia individual utilizando a medida de Kullback-Leibler
Bioequivalence trials are conducted to show that two formlllations, a reference dmg R and a test T, produces similar bioavailabitity. In Brazil, the introduction of the generic drug started in 1999 and the current analysis of the pharmacokinetics measures for rate and extent of the absorption is the average bioequivalence (ABE) which is not sufficient to gua
Publicado em: 2004
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33. Determinação do acetato de megestrol em plasma humano por cromatrografia líquida de alta eficiência acoplada ao espectrômetro de massa : aplicação em estudo de bioequivalência / Determination of megestrol acetate in human plasma by high-performance liquid chromatography coupled to mass spectrometry: application to a bioequivalence study
A sensitive and highly selective liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed to determine megestrol acetate in human plasma using betamethazone as the internal standard. The analyte and internal standard were extracted from plasma samples by hexane/ethyl acetate (1:1 v/v), and chromatographed on a C18 column. The mobile pha
Publicado em: 2004
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34. Estudo de bioequivalencia entre duas formulações farmaceuticas (comprimidos) contendo 20mg de Lisinopril, em voluntarios sadios de ambos os sexos
The aim of this study was to evaluate the bioequivalence between two formulations of lisinopril 20 mg. The test formulation was Lisinopril tablet 20 mg, manufactured by Medley S/A Indústria Farmacêutica (Iot # LlC 06/01-1; expiry date: june/03) and the reference formulation was Zestril@ tablet 20 mg, manufactured by Astra Zeneca (Iot # A03534; expiry date:
Publicado em: 2003
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35. Limited-sampling strategy models for estimating the pharmacokinetic parameters of 4-methylaminoantipyrine, an active metabolite of dipyrone
Bioanalytical data from a bioequivalence study were used to develop limited-sampling strategy (LSS) models for estimating the area under the plasma concentration versus time curve (AUC) and the peak plasma concentration (Cmax) of 4-methylaminoantipyrine (MAA), an active metabolite of dipyrone. Twelve healthy adult male volunteers received single 600 mg oral
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-11
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36. Bioequivalência de comprimidos de nimesulida do mercado nacional / Bioequivalence of nimesulide tablets of the internal market
A nimesulida, é um fármaco sintético, pouco solúvel em água (0,01 mg/mL), classificado como antiinflamatório não esteróide, com atividade analgésica e antipirética. No Brasil são comercializadas várias especialidades farmacêuticas orais, contendo nimesulida, na dosagem de 100 e 200 mg. Em termos de saúde pública tais produtos, prescritos pelo
Publicado em: 2001