Bioadhesion
Mostrando 1-12 de 15 artigos, teses e dissertações.
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1. Assessment of an anti-ageing structured cosmetic formulation containing goji berry
Based on previous studies, it has been found that goji berry (GB), popularly known as a ‘miracle fruit’, has excellent antioxidant potential and can be used in the treatment of skin disorders associated with ageing. This study aimed to incorporate GB into a structured cosmetic in order to optimise its penetration. Stability studies of the formulation, de
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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2. Organic cocoa extract -loaded surfactant-based systems intended to skin bioadhesion
ABSTRACT This study was to develop, characterize, and evaluate the physical-chemical stability, in vitro antioxidant activity and in vitro safety profile of liquid crystalline systems (LCS) and microemulsions (MEs) with and without organic cocoa (OC) extract. LCS stabilized by surfactant polyoxyethylene 20 cetyl ether, containing water and oleic acid were st
Braz. J. Pharm. Sci.. Publicado em: 26/10/2017
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3. Formulation and evaluation of glipizide floating-bioadhesive tablets
The purpose of this study was formulation and in vitro evaluation of floating-bioadhesive tablets to lengthen the stay of glipizide in its absorption area. Effervescent tablets were made using chitosan (CH), hydroxypropyl methylcellulose (HPMC), carbopolP934 (CP), polymethacrylic acid (PMA), citric acid, and sodium bicarbonate. Tablets with 5% effervescent b
Brazilian Archives of Biology and Technology. Publicado em: 2010-10
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4. Synthesis, characterization of biocompatibility and evaluation of bioadhesion of n-carboxymethylchitosan nanoparticles in hybrid networks with poliacrylic acid / Síntese, caracterização e avaliação da biocompatibilidade e bioadesão de nanopartículas de n-carboximetilquitosana em redes híbridas com ácido poliacrílico
Chitosan nanoparticle complexes with polyacrylic acid have been used in nanotechnology, as they improve pharmacological activity, in chemical and biological terms, and in particular, increase drug bioavailability. The aim of this work is to evaluate the biocompatibility and bioadhesion of N-carboxymethyl derivatives of chitosan (N-CMC) with in situ polymeriz
Publicado em: 2009
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5. Effect of drying methods on retention of moist sucralfate gel properties
The aim of this work was to find a drying procedure for moist sucralfate gel capable of producing dried sucralfate gel that retains the original gel properties of bioadhesion, rheology, and micromeritics. Spray-drying and microwave-drying procedures were employed. Mannitol was used as a gel-protective substance during the drying processes. The spray drying o
Springer-Verlag.
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6. Evaluation of Polyethylene Oxide Compacts as Gastroretentive Delivery Systems
Compacts containing selected bioadhesive polymers, fillers, and binders were investigated for their potential as a bioadhesive gastroretentive delivery system to deliver water soluble and water insoluble compounds in the stomach. Compacts with 90:10, 75:25, and 60:40 of polyvinylpyrrolidone (PVP) and polyethylene oxide (PEO) were evaluated for swelling, diss
Springer US.
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7. 5-methyl-pyrrolidinone chitosan films as carriers for buccal administration of proteins
The purpose of this research was to investigate 5-methyl-pyrrolidinone chitosan (MPC) films as carriers for buccal delivery of protein drugs. Placebo and protein-loaded MPC films were prepared by casting and were then cross-linked with tripolyphosphate at different pH conditions. Myoglobin (MHb) was chosen as the model protein because its molecular weight is
Springer-Verlag.
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8. Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases
The main objective of this study was to develop a local, oral mucoadhesive metronidazole benzoate (MET) delivery system that can be applied and removed by the patient for the treatment of periodontal diseases. Mucoadhesive micromatricial chitosan/poly(ε-caprolactone) (CH/PCL) films and chitosan films were prepared. thermal behavior, morphology, and particle
Springer-Verlag.
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9. Microemulsion-Based Vaginal Gel of Clotrimazole: Formulation, In Vitro Evaluation, and Stability Studies
The objective of the present investigation was to develop and evaluate microemulsion-based gel for the vaginal delivery of clotrimazole (CMZ). The solubility of CMZ in oils and surfactants was evaluated to identify components of the microemulsion. The ternary diagram was plotted to identify the area of microemulsion existence. Various gelling agents were eva
Springer US.
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10. Formulation and Evaluation of Bioadhesive Buccal Drug Delivery of Tizanidine Hydrochloride Tablets
The study aim was concerned with formulation and evaluation of bioadhesive buccal drug delivery of tizanidine hydrochloride tablets, which is extensively metabolized by liver. The tablets were prepared by direct compression using bioadhesive polymers such as hydroxylpropyl methylcellulose K4M, sodium carboxymethyl cellulose alone, and a combination of these
Springer US.
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11. Development and evaluation of acid-buffering bioadhesive vaginal tablet for mixed vaginal infections
An acid-buffering bioadhesive vaginal tablet was developed for the treatment of genitourinary tract infections. From the bioadhesion experiment and release studies it was found that polycarbophil and sodium carboxymethylcellulose is a good combination for an acid-buffering bioadhesive vaginal tablet. Sodium monocitrate was used as a buffering agent to provid
Springer-Verlag.
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12. Formulation and optimization of controlled release mucoadhesive tablets of atenolol using response surface methodology
The aim of the current study was to design oral controlled release mucoadhesive compressed hydrophilic matrices of atenolol and to optimize the drug release profile and bioadhesion using response surface methodology. Tablets were prepared by direct compression and evaluated for bioadhesive strength and in vitro dissolution parameters. A central composite des
Springer-Verlag.