Effect of drying methods on retention of moist sucralfate gel properties
AUTOR(ES)
Maggi, L.
FONTE
Springer-Verlag
RESUMO
The aim of this work was to find a drying procedure for moist sucralfate gel capable of producing dried sucralfate gel that retains the original gel properties of bioadhesion, rheology, and micromeritics. Spray-drying and microwave-drying procedures were employed. Mannitol was used as a gel-protective substance during the drying processes. The spray drying of moist sucralfate gel gave rise to a powder whose water suspensions showed significantly reduced viscosity. The bioadhesion of spray-dried sucralfate gel was strongly reduced by drying. When mannitol was used as a gel protector, the spray-dried sucralfate in part maintained the original bioadhesion of moist sucralfate gel. The preparation of a dried sucralfate gel retaining the bioadhesion characteristics, avoiding the use of mannitol, was made possible using the microwavedrying procedure. The microwave-dried product possesses a granular morphology suitable for direct compression because it is a free flowing and strongly coherent granular powder.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2750354Documentos Relacionados
- The effect of residual water on antacid properties of sucralfate gel dried by microwaves
- Effect of convective and microwave methods on drying characteristics, color, rehydration and microstructure properties of ginger
- Effect of drying methods on long term storage of hazelnut
- Effect of drying conditions on the physical properties of impregnated orange peel
- Influence of drying methods on the physicochemical properties and nutritional composition of instant Tremella fuciformis
