Behavior Drug Effects
Mostrando 13-24 de 95 artigos, teses e dissertações.
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13. Involvement of β3-adrenergic receptors in the control of food intake in rats
This study examined the food intake changes evoked by intracerebroventricular (icv) injection of a selective agonist (BRL37344, 2 and 20 nmol) or antagonist (SR59230A, 10 and 50 nmol) of β3-adrenergic receptors in 24-h fasted rats (adult male Wistar rats, 200-350 g, N = 6/treatment). The animals were also pretreated with saline icv (SAL) or SR59230A (50 nmo
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-11
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14. Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses
It is known that chronic high levels of corticosterone (CORT) enhance aversive responses such as avoidance and contextual freezing. In contrast, chronic CORT does not alter defensive behavior induced by the exposure to a predator odor. Since different defense-related responses have been associated with specific anxiety disorders found in clinical settings, t
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-10
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15. Encapsulação de anfotericina B em lipossomas como sistemas de entrega modificada do fármaco para aplicação endovenosa / Encapsulation of amphotericin B into liposomes as modified delivery systems of the drug for endovenous administration
Fungal infections are among the most important causes of death among immunocompromised patients. Amphotericin B (AmB) is an antifungal polyene macrolide, representative of the group of chemotherapeutics which mechanism of action consists in change of membrane cell permeability. AmB is more damaging to fungal cells, but interacts with mammalian cell membrane
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/04/2010
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16. Effects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartate
Electrical or chemical stimulation of the dorsal periaqueductal gray (DPAG) has been accepted as an animal model of panic attacks. This study investigates the influence of anticipatory anxiety in the occurrence of panic-like behavior induced by N-methyl-D-aspartate (NMDA) microinjection into the DPAG of rats. Behavioral (i.e., contextual fear conditioning) a
Psychology & Neuroscience. Publicado em: 2010-06
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17. Potencial de abuso do modafinil e sensibilização cruzada com cocaína: um estudo pré-clínico. / Addictive potencial of modafinil and cross-sensitization with cocaine: a preclinical study.
Repeated or even a single exposure to all addictive drugs causes persistent locomotor sensitization, which is the result of an abundance of neuroplastic changes occurring within the circuitry involved in motivational behavior and is thought to play a key role in certain aspects of drug addiction. There is substantial controversy about the addictive potential
Publicado em: 2010
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18. Gardening for butterflies to come: a study of place attachment for drug addicts / Cuidando do jardim para virem as borboletas: um estudo sobre apropriação de espaço por dependentes químicos
The objective of this study is to describe how the place attachment occurs by male drug addicts, who are temporarily accommodated in a non-governmental organization, as well as identify other phenomena relevant to environmental psychology also present in this transitional environment. To do this, we used the concept of place attachment proposed by Pol (2002)
Publicado em: 2010
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19. Modelos matemáticos e computacionais para o comportamento do rato no labirinto em cruz elevado / Mathematical and computational models of the rat behavior into the Elevated Plus Maze
O Labirinto em Cruz Elevado (LCE) é um modelo animal para o estudo da ansiedade, suas bases biológicas e os efeitos de diferentes tipos de fármacos sobre o comportamento. Diferentes métodos têm sido usados para estudá-lo, dentro dos quais encontra-se a modelagem computacional. O presente trabalho junta-se a esses estudos utilizando as ferramentas da mo
Publicado em: 2010
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20. Opioidergic modulation of behavioral selection during lactation / Modulação opioidérgica na seleção comportamental após o parto
Treatment of postpartum female rats with morphine inhibits maternal behavior. The same treatment also stimulates foraging in adult animals. Exposure to drugs of abuse may result in a progressive and enduring enhancement of their reinforcing effects. Puerperal treatment with morphine leads to reverse tolerance to this drug, ultimately influencing the effects
Publicado em: 2009
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21. Efeito do pareamento da morfina i.p. com os braços abertos do labirinto em cruz elevado : um novo modelo para o estudo de adicção a drogas?
The Elevated Plus-Maze was adapted to assess the effects of the association between morphine administration and a previous aversive environment, in a Conditioned Place Preference procedure. This is a proposal of a new experimental procedure that can assess other environmental variables and other pharmacological functions effects of addiction, which cannot be
Publicado em: 2009
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22. Study of Fluidized Bed Hot Melt Granulation using solid Dispersion of Indomethacin / Estudo da granulação por solidificação de materiais fundidos em leito fluidizado utilizando dispersão sólida de indometacina
Recently, there is a renewed interest in the fluidized bed hot melt granulation for the preparation of solid dosage forms in the pharmaceutical industry and academy. The several advantages of this technique have attracted may researchers, but the main advantage are undoubtedly the solvent free operation and the short processing times. The aim of this work wa
Publicado em: 2009
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23. Tratamento neonatal com agonista 5-HT1A: repercussÃes sobre o desenvolvimento da atividade locomotora em ratos
Locomotion is an important function to living beings. Environmental changes that occur during the critical period of development can promote changes in the development of locomotor activity, bringing impairment for the individual. Works using automatic analysis of behavior are of great importance for the study of locomotion. Among the systems that can influe
Publicado em: 2009
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24. Micropartículas poliméricas à base de xilana e Eudragit S-100 contendo mesalazina visando à liberação cólon-específica
Colon-specific drug delivery systems have attracted increasing attention from the pharmaceutical industry due to their ability of treating intestinal bowel diseases (IBD), which represent a public health problem in several countries. In spite of being considered a quite effective molecule for the treatment of IBD, mesalazine (5-ASA) is rapidly absorbed in th
Publicado em: 2009