Barrel Temperature
Mostrando 13-16 de 16 artigos, teses e dissertações.
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13. Reconstruction and Stability of Secondary Structure Elements in the Context of Protein Structure Prediction
Efficient and accurate reconstruction of secondary structure elements in the context of protein structure prediction is the major focus of this work. We present a novel approach capable of reconstructing α-helices and β-sheets in atomic detail. The method is based on Metropolis Monte Carlo simulations in a force field of empirical potentials that are desig
The Biophysical Society.
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14. Native topology determines force-induced unfolding pathways in globular proteins
Single-molecule manipulation techniques reveal that stretching unravels individually folded domains in the muscle protein titin and the extracellular matrix protein tenascin. These elastic proteins contain tandem repeats of folded domains with β-sandwich architecture. Herein, we propose by stretching two model sequences (S1 and S2) with four-stranded β-bar
The National Academy of Sciences.
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15. Crystal Structure of Enzyme I of the Phosphoenolpyruvate Sugar Phosphotransferase System in the Dephosphorylated State*
The bacterial phosphoenolpyruvate (PEP) sugar phosphotransferase system mediates sugar uptake and controls the carbon metabolism in response to carbohydrate availability. Enzyme I (EI), the first component of the phosphotransferase system, consists of an N-terminal protein binding domain (EIN) and a C-terminal PEP binding domain (EIC). EI transfers phosphate
American Society for Biochemistry and Molecular Biology.
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16. Mutational Analysis of the Adeno-Associated Virus Type 2 (AAV2) Capsid Gene and Construction of AAV2 Vectors with Altered Tropism
Adeno-associated virus type 2 (AAV2) has proven to be a valuable vector for gene therapy. Characterization of the functional domains of the AAV capsid proteins can facilitate our understanding of viral tissue tropism, immunoreactivity, viral entry, and DNA packaging, all of which are important issues for generating improved vectors. To obtain a comprehensive
American Society for Microbiology.