Ultra-sonografia muscular cervical e pélvica de cães da raça Golden Retriever portadores e afetados pela Distrofia Muscular e em, terapia celular / Cervical e pelvic ultrasonography of Golden Retriever dogs carrying and affected by the Muscular Dystrophy and in cellular therapy

AUTOR(ES)

Juliana Passos Alves dos Santos

DATA DE PUBLICAÇÃO

2008

RESUMO

The dogs Golden Retriever with Muscular Dystrophy (GRMD) are considered experimental models for study of the Muscular Dystrophy of Duchenne that acomete human, and they are genetically homologue. We use the muscular ultrasound to evaluate the therapeutical evolution of injection of stem cells (SC). For this experiment we use 8, being 6 affected for disease and 2 not affected (carrying and male normal). We evaluate of qualitative form (visual) and quantitative (digital) the cervical muscles splenius and capitis semispinalis and the pelvic muscle semitendinosus and carry through muscular mensure. In relation to the cervical muscles we verify that it does not have visual alteration in the architecture of fibres, however the treat dog saw arterial presented minors props up in the digital analysis in relation the dog has controlled affected, leaving suspicion on the migration of SC in this muscular group. Splenius presented greater echogenicity that the muscle semispinalis capitis in 7 animals. For the muscle semitendinosus, the carrier presented high echogenicity; the affected ones had presented variable degrees of alteration of the muscular architecture and increase of echogenicity; the normal male presented regular fibres, however in some examinations he presented high echogenicity being able to be consequence of the transducer angle. How much to the mensure, it has difference between the affected ones and not affected for the muscle splenius and due to hypertrophy that affects the pelvic muscles, it was not possible to establish differences between the two groups. We conclude that the ultrasonography with transducers of up to 7,5 MHz is not viable to follow therapeutical evolution of injection of SC in muscles with the pseudohypertrophy of GRMD, had the severe modification of the architecture, not being possible the detention of probable repairs of the muscle.

ASSUNTO(S)

celular therapy distrofia muscular terapia celular ultrasonography golden retriever golden retriever ultrasonografia muscular dystrophy

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