Two-state models of protein folding kinetics
AUTOR(ES)
Zwanzig, Robert
FONTE
National Academy of Sciences
RESUMO
The folding of some proteins appears to be a two-state kinetic process. A two-state kinetic model is justified if protein molecules rapidly equilibrate between different unfolded conformations prior to complete folding. Here I show that this rapid equilibration is a natural consequence of reasonable assumptions about reaction rate constants and folding thermodynamics.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=19262Documentos Relacionados
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