Interacting enzyme systems at steady state: further Monte Carlo calculations on two-state molecules.

AUTOR(ES)

Hill, T L

RESUMO

In this work, Monte Carlo calculations were made on a 10 x 10 lattice of two-state, steady-state enzyme molecules in two special cases for which the Bragg-Williams (mean field) approximation had earlier produced some very interesting phase-transition properties. The Monte Carlo results proved to be similar to Bragg-Williams in some respects but not in others. The discrepancies are attributed primarily to; (i) inadequate treatment by Bragg-Williams of strong negative cooperativity; and (ii) the finite size of the 10 x 10 lattice used in the exact calculations.

Documentos Relacionados

• Interacting enzyme systems at steady state: location of the phase transition in approximations of the mean field type.
• Two-state models of protein folding kinetics
• A two-state kinetic model for the unfolding of single molecules by mechanical force
• Three-state, steady-state Ising systems: Monte Carlo and Bragg-Williams treatments
• A homotropic two-state model and auto-antagonism