Toward efficient asymmetric hydrogenation: Architectural and functional engineering of chiral molecular catalysts

AUTOR(ES)

Noyori, Ryoji

FONTE

National Academy of Sciences

RESUMO

Asymmetric hydrogenation uses inexpensive, clean hydrogen gas and a very small amount of a chiral molecular catalyst, providing the most powerful way to produce a wide array of enantio-enriched compounds in a large quantity without forming any waste. The recent revolutionary advances in this field have entirely changed the synthetic approach to producing performance chemicals that require a high degree of structural precision. The means of developing efficient asymmetric hydrogenations is discussed from a mechanistic point of view.

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